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IRF8
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs903202 | |||
| rs16940186 | |||
| rs16940202 | |||
| rs6540239 | |||
| rs6540240 | |||
| rs7193275 | |||
| rs11117432 | |||
| rs138032891 | |||
| rs138854374 | |||
| rs142267779 | |||
| rs144424711 | |||
| rs145048966 | |||
| rs200724492 | |||
| rs202046728 | |||
| rs28368114 | |||
| rs377181003 | |||
| rs57770209 | |||
| rs756665891 | |||
| rs764339986 | |||
| rs774835569 |
Find on This Page
Summary
IRF8 encodes interferon regulatory factor 8. Variants of IRF8 may play a role in rheumatoid arthritis by stimulating autoimmune inflammation.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing IRF8.
Protein names
Found in These Blog Articles
More Information
The IRF8 gene encodes interferon regulatory factor 8, an immune system signal that activates interferons [R].
Interferons are named for their ability to interfere with viral replication; they are one of the lines of defense our bodies have against viruses that we have never encountered before [R].
Interferons are absolutely essential to a healthy response to viral infection. However, they have also been implicated in inflammatory diseases and complications from infection [R].
Variation in the IRF8 gene has been associated with many inflammatory disorders, but it is of particular interest in autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis [R, R, R].
Mice without IRF8 do not develop lupus, leading researchers to believe that IRF8 is required to develop certain autoimmune conditions [R].
Higher levels of IRF8 activity (and, thus, higher levels of interferon activation) are associated with rheumatoid arthritis and other inflammatory diseases [R, R, R].
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