IRF5

SNP Table

variant	genotype	frequency	risk allele
rs2004640
rs781133285
rs41298401
rs73461582
rs1874330
rs3778754
rs142029795
rs34632345
rs73228760
rs142400064
rs10954213
rs10954214
rs11761199
rs11770589
rs142738614
rs1874327
rs1874328
rs3778751
rs3778752
rs3778753

22564 associated SNPs in total

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Summary Blog Articles GHR Function Frequently Asked Questions

Summary

IFN-regulatory factor 5 gene increases IFN-alpha. Interferon alpha induces the kynurenine pathway and is associated with depression because of NMDA overactivity (Ref)

Protein names

interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120]

Found in These Blog Articles

The Role of Interferons in Rheumatoid Arthritis (IRF5)

IRF5 regulates the interferon response and promotes Th1 and Th17 inflammation. What is its role in rheumatoid arthritis?

How Does This Gene Stimulate Th1 and Promote IBD? (IRF5)

IRF5 stimulates the Th1 response, suppresses IL-10, and may promote the development of ulcerative colitis. Learn more here.

The Role of Interferons & the Th1 Response in Lupus (IRF5)

IRF5 encodes a protein that regulates interferons and promotes Th1 & Th17 inflammation. How does it affect lupus?

GHR Function

The protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. When a virus is recognized in the cell, the IRF5 gene is turned on (activated), which leads to the production of IRF5 protein. The protein binds to specific regions of DNA that regulate the activity of genes that produce interferons and other cytokines. Cytokines are proteins that help fight infection by promoting inflammation and regulating the activity of immune system cells. In particular, interferons control the activity of genes that help block the replication of viruses, and they stimulate the activity of certain immune system cells known as natural killer cells.

More Information

IFN-regulatory factor 5 gene.Increases IFN-alpha. Must have STAT4 T allele to make this harmful. IFNa=depression Interferon alpha induces the kynurenine pathway and is associated with depression because of NMDA overactivity (Ref)

rheumatoid arthritis Genetics Home Reference provides information about rheumatoid arthritis. systemic lupus erythematosus Genetics Home Reference provides information about systemic lupus erythematosus. systemic scleroderma Several normal variations in the IRF5 gene have been associated with an increased risk of developing systemic scleroderma, which is an autoimmune disorder characterized by the buildup of scar tissue (fibrosis) in the skin and internal organs. Although the IRF5 gene is known to stimulate the immune system in response to viruses, it is unknown how the gene variations contribute to the increased risk of systemic scleroderma. Researchers believe that a combination of genetic and environmental factors may play a role in development of the condition. ulcerative colitis Genetics Home Reference provides information about ulcerative colitis. autoimmune disorders Studies have associated normal variations in the IRF5 gene with an increased risk of several autoimmune disorders. Autoimmune disorders occur when the immune system malfunctions and attacks the body’s tissues and organs. These disorders include systemic lupus erythematosus, Sjögren syndrome, and rheumatoid arthritis. There is some evidence that certain variations of the IRF5 gene are associated with increased activity of the gene and elevated cytokines. However, it is unknown what role, if any, these effects play in the increased risk of autoimmune disorders. Researchers believe that a combination of genetic and environmental factors may contribute to the development of these conditions.

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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