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INSIG2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs74335158 | |||
| rs6754845 | |||
| rs10192689 | |||
| rs2113482 | |||
| rs10167050 | |||
| rs13024267 | |||
| rs1477447 | |||
| rs4142226 | |||
| rs4849653 | |||
| rs6730069 | |||
| rs6750836 | |||
| rs7563459 | |||
| rs11889588 | |||
| rs13393332 | |||
| rs1352083 | |||
| rs1559509 | |||
| rs17047750 | |||
| rs2042492 | |||
| rs13031831 | |||
| rs58573962 |
Summary
Insulin-induced gene 2 (INSIG2). INSIG2 gene is associated with obesity [R]. A large genetic association study showed evidence for SNP with obesity in several cohorts [R].
INSIG2 gene was consistently associated with increased BMI [R]. INSIG2 (but not INSIG1) plays a role in fat creation, with a marked increase in gene expression during fat cell creation (R, R2, R3).
The production of INSIG2 also mildly correlates with BMI (R). Therefore, it seems like pro-INSIG2 factors will increase obesity risk.
Protein names
Found in These Blog Articles
More Information
INSIG-2 blocks lipid synthesis in a cholesterol-dependent fashion (by inhibiting the breakdown of SREBPs) [R]. INSIG2 increases SREBP indirectly.
SREB proteins are required for cholesterol synthesis and for uptake and fatty acid synthesis (INSIG2 binds to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi) (R). On the other hand, INSIG2 reduces the creation of fat cells in early stages (R) and decreases triglycerides (R).
INSIG2 is under circadian control (via REV-ERBalpha) (R). Excess INSIG2 appeared to suppress some of the actions of chemotherapeutic drugs (R).
Lifestyle & Supplement Interactions
- Exercise….People with a SNP that causes weight gain with a bad INSIG2 gene lost more weight with exercise (R).
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