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IL6R
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs2228145 | |||
| rs10908836 | |||
| rs10908838 | |||
| rs6689306 | |||
| rs7549338 | |||
| rs7553796 | |||
| rs34926346 | |||
| rs10908837 | |||
| rs7549250 | |||
| rs4072391 | |||
| rs6694258 | |||
| rs12129500 | |||
| rs6689393 | |||
| rs7526131 | |||
| rs7536152 | |||
| rs10752641 | |||
| rs10908839 | |||
| rs12133641 | |||
| rs2229238 | |||
| rs4129267 |
Find on This Page
Summary
The IL6R gene encodes the receptor for interleukin 6 (IL-6), an inflammatory cytokine [R].
IL-6 is an immune messenger (cytokine). Depending on the situation, IL-6 can increase or decrease inflammation. However, it is usually proinflammatory [R, R].
People with low IL-6 levels may have low immune function and be predisposed to infections. High IL-6 levels have been linked to chronic inflammation and inflammatory conditions [R, R, R].
Variants in IL6R have been linked to [R, R, R, R, R, R]:
- Atrial fibrillation
- Coronary artery disease
- Congenital heart disease
- Asthma
- Inflammatory marker levels
- Autoimmune disease
Protein names
Found in These Blog Articles
GHR Function
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
More Information
Covered on Genetics Home Reference: rheumatoid arthritisFrom NCBI Gene: Serum level of interleukin 6Serum level of interleukin-6 soluble receptor
From NCBI Gene: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] From UniProt: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
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