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IL4R
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1805010 | |||
| rs11645013 | |||
| rs8060025 | |||
| rs7186151 | |||
| rs7186985 | |||
| rs3024682 | |||
| rs11864220 | |||
| rs2107354 | |||
| rs2107355 | |||
| rs1049631 | |||
| rs3024678 | |||
| rs11859690 | |||
| rs12929847 | |||
| rs12931920 | |||
| rs12933283 | |||
| rs12933581 | |||
| rs147601229 | |||
| rs184658597 | |||
| rs201391429 | |||
| rs201672347 |
Find on This Page
Summary
This gene encodes a protein that regulates IgE production and promotes differentiation of Th2 cells. Mutations can cause asthma and skin problems (R).
Protein names
Found in These Blog Articles
GHR Function
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
More Information
From NCBI Gene: Human immunodeficiency virus type 1, susceptibility toIge responsiveness, atopic
From NCBI Gene: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] From UniProt: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
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