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IL17F
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs11465552 | |||
| rs117796773 | |||
| rs11465553 | |||
| rs145598353 | |||
| rs201102127 | |||
| rs2397084 | |||
| rs763780 | |||
| rs2179560 | |||
| rs524207 | |||
| rs10948683 | |||
| rs1125195 | |||
| rs1125196 | |||
| rs11751141 | |||
| rs11751159 | |||
| rs11751356 | |||
| rs11755293 | |||
| rs11755297 | |||
| rs11755816 | |||
| rs11757709 | |||
| rs11759291 |
Find on This Page
Summary
This gene encodes a cytokine similar to IL17.
This cytokine is produced by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF.
This cytokine is also found to inhibit the the creation of new blood vessels (angiogenesis) and induce endothelial cells to produce IL2, TGFB1/TGFB, and MCP-1.
It helps regulate cartilage turnover.
Plays a role in high neutrophils (neutrophilia) in the lungs and in the exacerbation of allergic lung inflammation.
Associated with Candidiasis, familial, 6: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida.
Protein names
Found in These Blog Articles
GHR Function
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.
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