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IKZF4
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs146915234 | |||
| rs202132270 | |||
| rs374618694 | |||
| rs747017110 | |||
| rs753820473 | |||
| rs75600413 | |||
| rs764681400 | |||
| rs79137765 | |||
| rs1055673908 | |||
| rs1701704 | |||
| rs2017445 | |||
| rs2456973 | |||
| rs772921 | |||
| rs12815387 | |||
| rs1701706 | |||
| rs2131569 | |||
| rs2658479 | |||
| rs34507011 | |||
| rs35961650 | |||
| rs4759239 |
Find on This Page
Summary
IKZF4 encodes IKAROS family zinc finger 4, also known as Eos. Variants of IKZF4 may play a role in alopecia areata by interfering with the production or activity of Tregs.. It controls lymphoid development [R].
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by directly supporting Eos or increasing Treg numbers and activity.
Protein names
Found in These Blog Articles
More Information
The IKZF4 gene encodes a protein called IKAROS family zinc finger 4 or “Eos,” which is involved in the development of white blood cells (T cells, B cells, and natural killer cells) [R].
Eos is essential for the correct development of regulatory T cells (Tregs), anti-inflammatory immune cells that prevent an immune response to normal, non-threatening cells and proteins. In mice lacking the Eos protein, Tregs failed to send tolerance signals to the immune system, and the animals developed systemic autoimmune disease [R, R].
Unsurprisingly, variants in the IKZF4 gene that lead to defects in Eos have been associated with various autoimmune conditions, including type 1 diabetes and alopecia areata. In type 1 diabetes, reduced Eos and impaired Tregs may lead to the production of autoantibodies against insulin and certain cell types in the pancreas [R].
In alopecia areata, reduced Eos and impaired Tregs may lead to the production of autoantibodies against a wide variety of tissue types [R].
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