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IKZF1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs10899750 | |||
| rs10274403 | |||
| rs77285773 | |||
| rs6583437 | |||
| rs7791218 | |||
| rs35803603 | |||
| rs6583438 | |||
| rs34967960 | |||
| rs55981617 | |||
| rs117111762 | |||
| rs61731355 | |||
| rs61731356 | |||
| rs7779749 | |||
| rs7789913 | |||
| rs1110701 | |||
| rs76083680 | |||
| rs10248903 | |||
| rs7800411 | |||
| rs12669559 | |||
| rs11765490 |
Find on This Page
Summary
The IKZF1 gene suppresses the immune cells that produce interferon-gamma (IFN-gamma). People with lupus tend to have increased IFN-gamma levels. It regulates lymphocyte differentiation [R].
Specific gene variants are associated with lower odds of lupus. They likely increase IKZF1 activity and reduce IFN-gamma levels.
Protein names
Found in These Blog Articles
GHR Function
More Information
The IKZF1 gene shifts the Th1/Th2 balance in favor of Th2 immune cells. Since Th1 cells produce interferon-gamma (IFN-gamma), this shift results in lower IFN-gamma levels [R].
IFN-gamma is crucial for antimicrobial immunity but also plays a role in lupus and other autoimmune conditions. Lupus patients tend to have higher IFN-gamma levels [R, R].
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