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IGF2BP2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs140669105 | |||
| rs200672412 | |||
| rs183414771 | |||
| rs1238651931 | |||
| rs141112109 | |||
| rs145173270 | |||
| rs370374613 | |||
| rs544265799 | |||
| rs746341734 | |||
| rs767636644 | |||
| rs757317521 | |||
| rs1422046174 | |||
| rs1355746809 | |||
| rs1057000384 | |||
| rs116094945 | |||
| rs1346842734 | |||
| rs181023952 | |||
| rs76838128 | |||
| rs1044031935 | |||
| rs111383767 |
Find on This Page
Summary
The IGF2BP2 gene codes for insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2). IGF2BP2 helps regulate growth and development by altering protein production [R, R].
For example, it can affect how much insulin-like growth factor 2 (IGF2) your body makes. High levels of IGF2 may cause beta cell dysfunction. Beta cells make and release insulin, a hormone that lowers blood sugar levels [R, R, R].
IGF2BP2 also plays a role in [R, R]:
- Insulin resistance
- Fat metabolism
- Brain cell specialization
- Tumor formation
IGF2BP2 variants are linked to [R, R]:
- Cancer
- Obesity
- Diabetes
Protein names
Found in These Blog Articles
GHR Function
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.
More Information
IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2) encodes a protein that binds to insulin like growth factor 2 (IGF2) and regulates IGF2 translation (R).
It is associated with breast cancer, diabetes, and obesity risk (R, R).
From NCBI Gene: This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014] From UniProt: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.
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