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GLS
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs6758866 | |||
| rs1168 | |||
| rs10198390 | |||
| rs6718902 | |||
| rs10182703 | |||
| rs1921913 | |||
| rs2203715 | |||
| rs887694 | |||
| rs11683679 | |||
| rs11688967 | |||
| rs12987113 | |||
| rs12990256 | |||
| rs2108818 | |||
| rs3771313 | |||
| rs4597558 | |||
| rs10173099 | |||
| rs10199181 | |||
| rs13029247 | |||
| rs1547550 | |||
| rs2030171 |
Find on This Page
Summary
GLS codes for glutaminase, an enzyme that helps promote the growth and expansion of cells involved in joint destruction. Variants of GLS may play a role in rheumatoid arthritis by increasing the production or activity of glutaminase.
Lifestyle modifications may counteract the effects of these variants by decreasing glutaminase production or activity.
Protein names
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More Information
The GLS gene codes for glutaminase, an enzyme that helps convert the amino acid glutamine into glutamate [R].
The conversion of glutamine into glutamate may be essential for the growth and expansion of a type of cell called fibroblast-like synoviocyte. These cells are found in the most mobile and common type of joint in the human body: the synovial joint [R, R].
Fibroblast-like synoviocytes may play major roles in promoting joint inflammation, the destruction of joints, and the development of rheumatoid arthritis [R].
Scientists observed higher levels and greater activity of glutaminase in fibroblast-like synoviocytes derived from rheumatoid arthritis patients. In mice with rheumatoid arthritis, blocking glutaminase activity inhibited the growth of fibroblast-like synoviocytes and reduced joint inflammation [R].
Not surprisingly, variants of GLS have been associated with rheumatoid arthritis. These variants may increase production or activity of glutaminase, which may lead to the growth and expansion of fibroblast-like synoviocytes, and consequent joint destruction [R, R, R, R].
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