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SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more
GCKR
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1260326 | |||
| rs149847328 | |||
| rs201754753 | |||
| rs573498430 | |||
| rs756799078 | |||
| rs777999797 | |||
| rs146053779 | |||
| rs183739892 | |||
| rs780121754 | |||
| rs12615690 | |||
| rs4665384 | |||
| rs4666003 | |||
| rs58737572 | |||
| rs60089768 | |||
| rs2384654 | |||
| rs6749426 | |||
| rs13026621 | |||
| rs1528404 | |||
| rs28381983 | |||
| rs1919125 |
Summary
The GCKR gene encodes the glucokinase regulator protein [R].
Glucokinase is highly active in the pancreas, where it helps regulate blood sugar. It senses blood sugar levels in the blood and stimulates insulin secretion from pancreatic islet cells. GCKR regulates glucokinase activity [R, R].
Mutations in GCKR may cause maturity-onset diabetes of the young (MODY) [R].
Variants in GCKR have also been linked to [R, R, R]:
- Fatty liver disease
- Voluntary physical exercise
- High blood lipids
Protein names
Found in These Blog Articles
GHR Function
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
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