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Naps
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DNAH11
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs2285943 | |||
| rs2285944 | |||
| rs10269582 | |||
| rs12670130 | |||
| rs62441683 | |||
| rs6975129 | |||
| rs77306873 | |||
| rs78583796 | |||
| rs201943194 | |||
| rs10950854 | |||
| rs6976617 | |||
| rs10224537 | |||
| rs4615458 | |||
| rs146772002 | |||
| rs73064469 | |||
| rs7795069 | |||
| rs56029521 | |||
| rs111675895 | |||
| rs13236023 | |||
| rs4314550 |
Find on This Page
Summary
This gene encodes a protein that is involved in the movement of respiratory cilia. Mutations can cause dyskinesia (R).
Protein names
GHR Function
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
More Information
Covered on Genetics Home Reference: heterotaxy syndromeprimary ciliary dyskinesiaFrom NCBI Gene: Ciliary dyskinesia, primary, 7From UniProt: Kartagener syndrome (KTGS): An autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). [MIM:244400] Ciliary dyskinesia, primary, 7 (CILD7): A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. [MIM:611884]
From NCBI Gene: This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013] From UniProt: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
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