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COPB2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1187774092 | |||
| rs1252559697 | |||
| rs144633885 | |||
| rs1472937298 | |||
| rs148644997 | |||
| rs185591728 | |||
| rs186922212 | |||
| rs199603762 | |||
| rs779822252 | |||
| rs79043251 | |||
| rs10935322 | |||
| rs11717119 | |||
| rs11928018 | |||
| rs13327001 | |||
| rs13327467 | |||
| rs13434189 | |||
| rs1586862 | |||
| rs1609482 | |||
| rs17395255 | |||
| rs17395262 |
Find on This Page
Summary
COPB2 codes for beta'‐COP, a protein that promotes cell survival by stimulating the cell death regulator bcl-2. Variants of COPB2 may play a role in male-pattern baldness by dysregulating the production of beta'‐COP and bcl-2.
Lifestyle and supplement modifications may counteract the effects of these variants by slightly increasing or preventing a decrease in bcl-2 production.
Protein names
Found in These Blog Articles
More Information
The COPB2 gene codes for COPI coat complex subunit beta 2 (beta'‐COP), a protein involved in the transport of other proteins within cells [R].
While the mechanism is unclear, beta'‐COP has been reported to increase production of the cell death regulator bcl-2 [R].
Bcl-2 may be essential for regulating the hair growth cycle, in which hair grows within a follicle, detaches from the follicle, and falls out. Cell growth and expansion (proliferation) and cell death must remain balanced in order for this cycle to be maintained [R].
In line with this, bcl-2 production has been reported to be increased during hair growth and decreased during hair detachment [R].
Interestingly, mice that lack bcl-2 experience slower rates of hair growth, while mice that produce excess bcl-2 experience accelerated hair loss — suggesting that bcl-2 must remain balanced for normal hair cycling [R].
Variants of COPB2 have been associated with male-pattern baldness. These variants may dysregulate the production of beta'‐COP and bcl-2, resulting in hair cycle perturbation [R, R, R, R].
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