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COG6
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs3812882 | |||
| rs3812883 | |||
| rs41286961 | |||
| rs7990283 | |||
| rs1172374735 | |||
| rs1259574987 | |||
| rs1345426365 | |||
| rs141978569 | |||
| rs1491287411 | |||
| rs3812884 | |||
| rs3812885 | |||
| rs3812886 | |||
| rs3812887 | |||
| rs3812888 | |||
| rs4261404 | |||
| rs4275735 | |||
| rs4277227 | |||
| rs4300508 | |||
| rs4306389 | |||
| rs4312180 |
Find on This Page
Summary
COG6 encodes conserved oligomeric Golgi complex subunit 6, which helps to maintain structure and activity of the Golgi apparatus. Variants of COG6 may play a role in rheumatoid arthritis by increasing immune system activity and antibody production through ADAM33 (R).
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by regulating ADAM33.
Protein names
Found in These Blog Articles
GHR Function
Required for normal Golgi function.
More Information
The COG6 gene encodes a protein called conserved oligomeric Golgi complex subunit 6. This protein is part of the Golgi apparatus, an important structure for the basic function of all cells [R].
Because COG6 has such an important, central function, it’s not surprising that variations in this gene can cause disabling results. COG6 deficiency is the name given to any disorder caused by a lack of COG6; symptoms of these disorders may include [R, R]:
- Physical deformities
- Uncoordinated movement
- Cognitive slowness
- Inflammatory bowel disease (IBD)
- Liver disease
- Recurrent infections
Most variants in the COG6 gene do not have a strong enough effect to cause COG6 deficiency outright. However, less severe variants have been associated with rheumatoid arthritis and other autoimmune conditions [R, R, R, R].
Researchers have speculated that COG6 affects the immune system through the ADAM proteases, including ADAM33, which has itself been implicated in inflammatory disease [R].
Patients with COG6 deficiencies typically have immune deficiencies and very low antibody production. People with rheumatoid arthritis usually have the opposite problem: an overactive immune system and high antibody production against the body’s own tissues [R, R].
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