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CHDH
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs12676 | |||
| rs6445607 | |||
| rs6445608 | |||
| rs768947265 | |||
| rs1286355718 | |||
| rs2289206 | |||
| rs6801605 | |||
| rs9001 | |||
| rs11718497 | |||
| rs35518479 | |||
| rs4687750 | |||
| rs1291440576 | |||
| rs180916900 | |||
| rs200094235 | |||
| rs201270449 | |||
| rs201987319 | |||
| rs369163349 | |||
| rs375568671 | |||
| rs756480475 | |||
| rs761638939 |
Summary
CHDH codes for choline dehydrogenase, which converts choline to betaine [R, R2, R3, R4, R5, R6]. Choline dehydrogenase travels to the mitochondria. Variations in this gene can affect susceptibility to choline deficiency.
Choline helps metabolize fats and produce phospholipids, has anti-inflammatory properties, can reduce the risk of heart attacks and stroke, and helps with memory recall and learning.
Protein names
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GHR Function
More Information
CHDH codes for choline dehydrogenase, which converts choline to betaine [R, R2, R3, R4, R5, R6]. Choline dehydrogenase travels to the mitochondria.
Variations in this gene can affect susceptibility to choline deficiency. Choline dehydrogenase catalyzes the conversion of choline into the intermediate glycine betaine aldehyde, leading to the formation of betaine.
Betaine helps the cells retain water and is also a methyl donor. Functioning of this enzyme depends on oxygen [R]. PQQ is a cofactor. Choline digests fats to prevent buildup in the liver. [R, R2]
Fat accumulation can especially hurt organs such as the liver and muscles and causes an abnormally high self-destruction of white blood cells, death of kidney cells that leads to blood vessel rupture, fatigue, and sleep trouble. [R, R2, R3] Choline has anti-inflammatory properties for the body. [R]
Choline can reduce risks of heart attacks and strokes. [R, R2] Without CDHD, sperm has a reduced ability to swim, which causes about a third of male sterility cases. [R. R2] Choline processing is needed for optimal memory recall and learning. [R, R2]
Men and postmenopausal women were more susceptible to liver and muscle damage in the case of choline deficiency than premenopausal women. [R]
Mutants of CHDH can make one more/less susceptible to fat accumulation. Most mutants make people more susceptible. [R] Mutants of CHDH are linked to absence of teeth development.[R] Choline maintains the fluidity of fat layers of cells. [R]
CHDH is involved in expression of genes functionally that metabolize folate, cell suicide, DNA damage-repair, cell cycle regulation, immune response, epigenetic regulation, and DNA strand-end maintenance. [R, R2] Fetuses may develop Neural Tube Defect (which harms the brain, spine, and spinal cord) without sufficient quantities of choline. [R, R2]
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