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CD2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs699738 | |||
| rs150567561 | |||
| rs798039 | |||
| rs798033 | |||
| rs35880225 | |||
| rs41313991 | |||
| rs182592716 | |||
| rs1402223797 | |||
| rs142374557 | |||
| rs151252237 | |||
| rs181664416 | |||
| rs186465057 | |||
| rs375969497 | |||
| rs798036 | |||
| rs798045 | |||
| rs10489634 | |||
| rs1286474888 | |||
| rs810048 | |||
| rs798034 | |||
| rs115452483 |
Find on This Page
Summary
CD2 and CD101 encode two white blood cell surface proteins. Variants of CD2 and CD101 may play a role in rheumatoid arthritis by increasing inflammatory T cells and reducing Tregs.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing Tregs and correcting the balance between different types of T cells.
Protein names
Found in These Blog Articles
More Information
A variant that may affect the function or expression of either the CD2 or CD101 gene has been associated with increased rates of rheumatoid arthritis [R, R].
CD2 encodes cluster of differentiation 2, a protein found on the surface of some types of white blood cells. CD2 helps T cells develop and move around the body, promoting an immune response. CD101 encodes cluster of differentiation 101, also known as IGSF2 or immunoglobulin superfamily member 2. CD101 is similarly expressed on the surface of some white blood cells, but it is believed to have an anti-inflammatory function [R, R, R].
Both CD2 and CD101 have been implicated in a variety of diseases, which isn’t surprising given their presence on important immune cells. The most significant of these associations is with diabetes and rheumatoid arthritis [R, R, R].
People with rheumatoid arthritis may have a modified version of CD2 on their T cells that increases the intensity of the immune response. Some researchers believe that preventing CD2 from interacting with other immune molecules, especially CD58, may help slow the progression of arthritic disease [R, R].
By contrast, CD101 is believed to increase the activity of Treg cells, which are anti-inflammatory and prevent immune reactions to harmless triggers [R].
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