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Naps
BLK
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs3816668 | |||
| rs4841550 | |||
| rs2729940 | |||
| rs7820492 | |||
| rs12548884 | |||
| rs2409781 | |||
| rs6988443 | |||
| rs115068920 | |||
| rs2736335 | |||
| rs149457873 | |||
| rs10098597 | |||
| rs1478897 | |||
| rs17153419 | |||
| rs2248696 | |||
| rs2248700 | |||
| rs2409784 | |||
| rs2618476 | |||
| rs2736345 | |||
| rs4366049 | |||
| rs7828916 |
Find on This Page
Summary
The BLK gene controls the activity of white blood cells via NF-kB. Altered white blood cell function is the hallmark of lupus and other autoimmune conditions. Specific gene variants may alter BLK function and NF-kB levels. They’ve been associated with higher lupus rates.
Dietary and lifestyle modifications may prevent or improve lupus by targeting the BLK variants.
Protein names
Found in These Blog Articles
More Information
The BLK gene controls the development and activity of B cells, a type of white blood cells that produce antibodies. Altered B cell function is the hallmark of lupus and other autoimmune conditions [R, R].
Variants in the BLK gene may affect the levels of NF-kB, the ‘master controller’ of inflammation and immune response [R, R].
NF-kB has dual roles in autoimmunity, with both high and low levels being a potential contributing factor. However, most autoimmune conditions eventually cause widespread inflammation with elevated NF-kB [R, R, R].
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