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BCL11A
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs150125298 | |||
| rs1403416912 | |||
| rs141406273 | |||
| rs745625531 | |||
| rs768112365 | |||
| rs770749600 | |||
| rs1049336006 | |||
| rs114252508 | |||
| rs115990154 | |||
| rs12474913 | |||
| rs1266978615 | |||
| rs748323077 | |||
| rs897531341 | |||
| rs982601248 | |||
| rs1038762378 | |||
| rs1308957151 | |||
| rs1346191731 | |||
| rs187745290 | |||
| rs551904769 | |||
| rs576954502 |
Find on This Page
Summary
The BCL11A gene encodes B-cell lymphoma/leukemia 11A. Variants of BCL11A may play a role in male-pattern baldness by disrupting the development of skin tissues.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by supporting correct BCL11A function.
Protein names
Found in These Blog Articles
GHR Function
Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1.
More Information
The BCL11A gene encodes a protein called BAF chromatin remodeling complex subunit BCL11A or B‐cell lymphoma/leukemia 11A. BCL11A is a transcription factor, meaning that it regulates the expression of many other genes [R, R].
BCL11A is expressed primarily in the brain and blood cell-producing tissues and can be used as a marker for leukemia and other types of cancer. Mutations in the BCL11A gene can cause intellectual and developmental disabilities [R, R, R, R].
People with BCL11A mutations may have very fine hair and receding hairlines at a young age, among a long list of other possible symptoms. However, the majority of research on this gene has been related to neurological effects or cancer, and the relationship between BCL11A and hair loss is poorly understood [R].
Some research suggests that BCL11A plays a role in the early development and organization of skin cells. The skin of animals without BCL11A is more susceptible to bacterial infection [R, R].
One BCL11A variant has been associated with male-pattern baldness. Researchers have not yet investigated whether this variant increases or decreases BCL11A function in some way [R].
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