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ALX4
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs3824915 | |||
| rs12421995 | |||
| rs66716358 | |||
| rs1489729247 | |||
| rs182274454 | |||
| rs372830230 | |||
| rs374726657 | |||
| rs756167646 | |||
| rs767495097 | |||
| rs79200219 | |||
| rs866420250 | |||
| rs10769038 | |||
| rs10838255 | |||
| rs10838258 | |||
| rs10838259 | |||
| rs11037946 | |||
| rs11037948 | |||
| rs11037950 | |||
| rs4755809 | |||
| rs144961504 |
Find on This Page
Summary
ALX4 codes for a protein that helps fetal development of the skull, head, and face. It may promote hair growth by interacting with LEF-1, a component of the Wnt signaling pathway. Variants of ALX4 may play a role in male-pattern baldness by dysregulating ALX4 and LEF-1.
Lifestyle and supplement modifications may counteract the effects of these variants by boosting the Wnt signaling pathway.
Protein names
Found in These Blog Articles
GHR Function
The ALX4 gene provides instructions for making a member of the homeobox protein family. Homeobox proteins direct the formation of body structures during early embryonic development. The ALX4 protein is necessary for normal development of the skull and formation of the head and face, which begins early in fetal development. This protein is also involved in the formation of skin layers, but its role in this process is poorly understood.
The ALX4 protein is a transcription factor, which means that it attaches (binds) to DNA and controls the activity of certain genes. Specifically, the protein controls the activity of genes that regulate cell growth and division (proliferation), cell maturation and specialization (differentiation), cell movement (migration), and cell survival. The regulation of these functions ensures that cells start and stop growing at specific times and that they are positioned correctly during development.
More Information
The ALX4 gene codes for ALX homeobox 4 (ALX4), a protein that turns genes on or off [R].
In hair follicles, the function of ALX4 may be potentiated by LEF-1. LEF-1 is a component of the Wnt signaling pathway, which is considered essential for the development of hair follicles and the progression of hair growth cycles [R, R, R].
Indeed, mutations in ALX4 have been linked to a rare disorder called frontonasal dysplasia type 2, characterized by hair loss and abnormal development of the head and face. These mutations have been suggested to produce a dysfunctional ALX4 protein [R, R, R].
However, one study has suggested that the interaction between ALX4 and LEF-1 must remain dynamic. In this study, elevated levels of ALX4 or excess ALX4 activity (mediated by LEF-1) lowered the production of a protein that may help promote normal hair cycle progression [R, R].
Variants of ALX4 have been associated with male-pattern baldness. These variants may dysregulate ALX4 and LEF-1, resulting in dysfunctional Wnt signaling and perturbed hair growth [R, R, R, R, R, R].
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