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ADORA2A
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs2298383 | |||
| rs761339165 | |||
| rs5760423 | |||
| rs73879064 | |||
| rs9620388 | |||
| rs2236624 | |||
| rs5751876 | |||
| rs1015011 | |||
| rs1033485501 | |||
| rs372567965 | |||
| rs5996713 | |||
| rs9624480 | |||
| rs140324 | |||
| rs140330 | |||
| rs141349354 | |||
| rs151290801 | |||
| rs2032115 | |||
| rs2232866 | |||
| rs3788372 | |||
| rs3966269 |
Find on This Page
Summary
The ADORA2A gene encodes adenosine receptor A2A [R].
This receptor binds to adenosine in a region of the brain called the nucleus accumbens. This brain region is best known as the main location of dopamine signalling [R].
When adenosine binds to the A2A receptor, dopamine becomes less able to bind to its D2 receptor. As a result, higher ADORA2A gene expression results in more dopamine production [R, R].
Adenosine receptor A2A also has an effect on heartbeat rhythm, blood flow, immune function, pain perception, and the sleep cycle [R].
Variants in the ADORA2A gene have been associated with heart and brain disorders, including:
Protein names
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