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Unblock Your Body's Detox Pathways with a DNA Test

Your ability to detoxify toxins, pollutants, and byproducts is deeply rooted in your DNA. By understanding your body’s unique genetic makeup, you can support your detox pathways and reduce your risk for inflammation, oxidative stress, and chronic illness. SelfDecode helps you make the smartest choices to optimize your body’s natural cleansing systems.

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Discover How Your Body Processes Toxins—Based on Your Genes

The Detox Pathway Report reveals how your genes influence key detoxification pathways, so you can make informed decisions to support your liver, reduce toxic burden, and enhance longevity.

Phase I Detox: Understand how effectively your body converts toxins into less harmful substances, and how your genetics impact this first stage of detoxification.
Phase II Detox: Learn how well your body neutralizes and eliminates toxins, focusing on genetic variations that affect detoxification enzymes and pathways.
Glutathione Production: Learn whether your genes support this powerful detox and antioxidant defense system.

Why Take a DNA Detox Test?

Your detox pathways control how well your body clears out environmental toxins, medications, alcohol, and everyday metabolic waste. Weak spots in these pathways can lead to fatigue, brain fog, hormone imbalances, and poor immune health.

Identify Your Detox Strengths and Weaknesses

Learn where your detox systems shine—and where they may need extra support.

Protect Against Toxin Build-Up

Support your liver, kidneys, and other detox organs by identifying and addressing genetic bottlenecks.

Get Personalized Recommendations

Receive science-backed guidance on foods, supplements, and habits that help your body detox more effectively.

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What Does the Detox Pathway Report Test For?

This report analyzes genes involved in every stage of detoxification, including:

Phase I Enzymes

Cytochrome P450 genes (e.g., CYP1A2, CYP3A4, CYP2E1) that activate and process toxins.

Phase II Pathways

Genes like COMT, UGT, NAT2 and SULT1A1 that neutralize toxins for excretion.

Glutathione Pathway

Genes such as GSTP1, GSTA1, and GCLC that helps neutralize reactive intermediates.

Your report includes personalized advice on supporting sluggish detox genes, boosting glutathione and other protective compounds, avoiding triggers such as caffeine, alcohol, and environmental pollutants based on your SNPs, and incorporating nutrients and supplements like NAC, sulforaphane, and milk thistle—only if your body truly needs them.

Your Personalized Detox Plan

Based on your unique DNA, you’ll receive a personalized strategy designed to enhance your body’s ability to detoxify harmful substances. This plan considers how your genes influence the metabolism and elimination of toxins such as mold, heavy metals, pesticides, plastics, air pollutants, and more. Your custom recommendations may include:

Liver-Supportive Nutrition

Foods rich in antioxidants, cruciferous vegetables, and fiber to support Phase I and Phase II detox pathways.

Targeted Supplementation

Nutrients like NAC, selenium, zinc, vitamin C, glutathione, and polyphenols—chosen based on your genetic need and detox efficiency.

Lifestyle Interventions

Personalized guidance on hydration, sauna use, sleep hygiene, and strategies for minimizing exposure to pollutants.

Avoidance Recommendations

Alerts for environmental triggers like BPA, phthalates, and aluminum—only when your genetic profile suggests heightened sensitivity.

Your Detox Pathways Report translates complex genetic data into actionable insights so you can make smarter decisions about your environment, habits, and health.

See a sample Detox Pathways report

View our sample report, just one of over 1500 personalized insights waiting for you. With SelfDecode, you get more than a static PDF; you unlock an AI-powered health coach, tools to analyze your labs and lifestyle, and access to thousands of tailored reports packed with actionable recommendations.

Optimize Your Detox Pathways with SelfDecode

SelfDecode goes beyond toxins & detox—it’s a complete genetic wellness platform designed to help you live longer, cleaner, and healthier.

Personalized Recommendations

Get tailored diet, supplement, and lifestyle suggestions based on your health risks and goals.

1500+ DNA Health Reports

Explore personalized insights into 1500+ health topics using advanced polygenic risk scores, and see high-level results with Health Overview and Medical Overview reports.

Lab Tracking

Optimize 4,000+ lab markers with personalized guidance.

Nutrition Planner

Receive a personalized diet suggestion, custom meal plans, recipes, and shopping lists tailored to your body.

Suggested Labs

Get a personalized list of suggested lab tests based on your DNA & health goals.

SNP & Gene Search Tool

Discover your genotype for any SNP in our database of 200M+ genetic variants.

See Everything SelfDecode Has to Offer

Discover our full suite of health reports and features in one comprehensive guide.
Our Reports & Features Summary shows all the DNA results, tools, and insights you can get with SelfDecode.

Frequently Asked Questions

What is the Detox Pathway Report?

The Detox Pathway Report is a comprehensive genetic analysis that reveals how your DNA influences your body’s ability to process and eliminate toxins, pollutants, and metabolic byproducts. It analyzes key genes involved in Phase I detoxification, Phase II detoxification, and the critical glutathione pathway to provide personalized insights into your natural cleansing systems. The report helps you understand genetic bottlenecks in your detox pathways and provides science-backed recommendations to support your liver, kidneys, and other detox organs.

What are Phase I and Phase II detoxification?

Detoxification is a sophisticated two-phase process that occurs primarily in your liver: Phase I (Activation): This is your first line of defense where your body uses a family of enzymes called cytochrome P450 (CYP) to begin breaking down toxins. Key genes analyzed include CYP1A2, CYP3A4, CYP1A1, and more. This phase activates and processes toxins, but can produce reactive free radical molecules as byproducts.Phase II (Conjugation): In this phase, genes like COMT, UGT, NAT2, and SULT1A1 neutralize the activated toxins from Phase I by attaching them to large molecules, making them water-soluble for safe excretion. The glutathione pathway (involving genes like GSTP1, GSTA1, and GCLC) plays a crucial role in neutralizing reactive intermediates and protecting cells from damage.

What specific genes does the Detox Pathway Report analyze?

The report examines multiple gene families involved in detoxification:

Cytochrome P450 genes: CYP1A2, CYP3A4, CYP1A1, CYP1B1, CYP2C9 (Phase I activation)
Conjugation genes: COMT, UGT1A1, NAT2, SULT1A1 (Phase II processing)
Glutathione pathway genes: GSTP1, GSTA1, GCLC (neutralizing harmful compounds)
Additional detox-related genes that influence your body’s response to specific toxins

These genes work together to determine how efficiently your body handles various toxic substances.

What types of toxins does the report cover?

The report provides insights into your genetic ability to handle 50+ toxins from numerous sources, including:

Environmental Toxins: Air pollution, cigarette smoke (PAHs), flame retardants (PBDEs), plastics (BPA), phthalates, heavy metals (mercury, lead, arsenic, aluminum, cadmium)
Dietary & Lifestyle Toxins: Alcohol, caffeine, well-done meats (heterocyclic amines), pesticides (organophosphates, glyphosate), mold toxins (aflatoxins)
Internal Byproducts: Stress hormones (catecholamines) and metabolic waste products your body naturally produces

How is the Detox Pathway Report different from the Methylation Pathway Report?

While both reports relate to detoxification, they focus on different aspects:
Detox Pathway Report: Focuses specifically on how your body processes and eliminates external toxins and pollutants through Phase I, Phase II, and glutathione pathways. It analyzes genes like CYP450 enzymes, GST genes, and other detox-specific genes. Best for understanding environmental sensitivities and toxic burden.
Methylation Pathway Report: Focuses on one-carbon metabolism and methylation processes that affect detoxification, energy production, neurotransmitters, DNA repair, and homocysteine metabolism. It analyzes 30 SNPs across 20+ genes including MTHFR, COMT, MTR, MTRR, CBS, and PEMT. Best for understanding folate metabolism, B-vitamin needs, and cellular function.
Both reports complement each other for a complete detoxification picture.

What symptoms might indicate I need this report?

You may benefit from the Detox Pathway Report if you experience:

Fatigue, brain fog, or cognitive issues
Headaches or migraines from wine, perfumes, or cleaning products
Jittery or anxious feelings after one cup of coffee
Frequent asthma or sinus issues
Sensitivity to environmental scents or chemicals
Hormone imbalances
Poor immune health or frequent illness
Difficulty recovering from exposure to toxins

These “detox side effects” often indicate genetic variations affecting your body’s ability to process toxic substances efficiently.

What kind of recommendations will I receive?

The report provides actionable, personalized guidance including:

Dietary strategies: Foods that support your specific detox genes (like cruciferous vegetables for certain GST variants)
Supplement recommendations: Targeted nutrients like NAC (N-acetyl cysteine), sulforaphane, milk thistle, glutathione, and antioxidants—only if your genetic profile indicates you need them
Lifestyle modifications: Habits to support sluggish detox pathways
Avoidance strategies: Environmental triggers like BPA, phthalates, pesticides, or specific foods based on your genetic sensitivities
Specific nutrients: Dosing guidance for vitamins and minerals that support your detox enzymes

Each recommendation is prioritized based on your unique DNA and the strength of scientific evidence.

What makes SelfDecode's Detox Report unique?

SelfDecode’s Detox Pathway Report stands out because it:

Provides lab marker recommendations: Suggests specific blood, urine, or saliva tests to check based on your DNA, allowing you to see your genetic predispositions in action
Offers a truly holistic view: Analyzes Phase I, Phase II, glutathione pathway, and responses to dozens of specific toxins all in one comprehensive report
Features clear visual pathway diagrams: Complex detox science is simplified with easy-to-understand graphics
Integrates with your other health data: Can be combined with lab results, lifestyle assessments, and other DNA reports for complete personalization
Backed by solid, up-to-date evidence: Includes the latest genetic findings and dozens of references from peer-reviewed journals

Who should consider getting the Detox Pathway Report?

This report is especially valuable for people who:

Experience sensitivity to chemicals, fragrances, or environmental pollutants
Have unexplained chronic health issues like fatigue or brain fog
Work in occupations with high toxic exposure (healthcare, manufacturing, agriculture, beauty industry)
Live in areas with poor air quality or water contamination
Have family history of conditions linked to poor detoxification
Want to optimize their health and reduce disease risk proactively
Are interested in biohacking and personalized wellness strategies
Have tried generic detox programs without success

How do I get the Detox Pathway Report?

To access the Detox Pathway Report, you need:

A DNA sample: Either purchase a SelfDecode DNA test kit (simple cheek swab) or upload existing raw DNA data from companies like 23andMe, AncestryDNA, or others

A subscription plan: The Detox Pathway Report is included in SelfDecode’s Essential+ and Ultimate plans. It’s not included in the Essential plan. You can also purchase it as an upsell on the Essential plan.

Once your DNA is analyzed, the report is generated and available in your account within 2–3 weeks (for new test kits) or immediately (for uploaded data).

Get Your Detox Pathways DNA Report Today

Ready to support your body’s natural defenses and feel more energized? Unlock your personalized detox strategy now and take control of your long-term health.

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