What does the TFR2 (Iron) gene do?

The TFR2 (Iron) gene provides instructions for making transferrin receptor 2, a protein found mainly in liver cells. This receptor helps the liver take in iron that’s carried through the blood by transferrin (a transport protein). TFR2 also helps regulate levels of hepcidin, a hormone that acts like a “gatekeeper” for iron—controlling how much iron is absorbed from the diet and how much is released from storage into the bloodstream.

Why is the TFR2 (Iron) gene important?

TFR2 is important because it helps your body sense iron levels and adjust absorption and storage accordingly. Certain genetic variants in TFR2 have been associated with differences in iron-related markers such as transferrin saturation and other measures of iron status. In practical terms, your TFR2 genetics may help explain why you tend toward lower or higher iron availability, which can influence red blood cell development and may contribute to symptoms related to energy and fatigue—especially when combined with diet, life stage (e.g., pregnancy), and overall nutrient status.

What can I do based on my TFR2 (Iron) results?

Based on your TFR2 (Iron) results, you’ll receive 3 personalized recommendations focused on dietary guidance. These can include actionable steps such as choosing the most effective food sources of iron for your needs, improving iron absorption through smart nutrient pairing (for example, combining iron-rich foods with vitamin C), and identifying situations where it may be wise to discuss iron labs or supplementation decisions with a healthcare professional. Your report is designed to help you translate genetics into practical next steps, not guesswork.

How can TFR2 (Iron) genetic variants affect transferrin saturation and iron status?

Transferrin saturation reflects how much iron is bound to transferrin in the blood and is commonly used to assess iron deficiency or iron overload. TFR2 genetic variants may influence how effectively the liver senses transferrin-bound iron and regulates hepcidin. Because hepcidin controls iron absorption from the diet and iron release from storage, changes in this regulatory pathway can be associated with differences in iron-status markers—such as transferrin saturation and related red blood cell indices. Your report connects your TFR2 genetics to these biological pathways and provides dietary recommendations aligned with your results.

What do I get from a TFR2 (Iron) genetic test report for nutrition and fatigue?

A TFR2 (Iron) genetic test report translates your DNA into clear, personalized insights for nutrition, energy, and fatigue considerations. It analyzes genetic variants in TFR2, explains what they may imply for iron regulation and iron-status tendencies, and delivers 3 personalized dietary recommendations you can apply in everyday life. The report is designed to be scientifically grounded and easy to understand, helping you make more informed choices about iron-rich foods, absorption-supporting strategies, and when to consider discussing iron markers with a clinician.

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TFR2 (Iron)

Rated 4.83 out of 5 based on 6 customer ratings

4.8 (7 reviews)

TFR2 (Iron)

Rated 4.83 out of 5 based on 6 customer ratings

4.8 (7 reviews)

The report provides up to 3 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes Key Genetic Variants

Up to 3 DNA-Based, Science-Backed Recommendations

TFR2 (Iron)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your TFR2 (Iron) Variants: A DNA Gene Report

Do you struggle with low energy or fatigue and wonder if iron could be part of the story? Have you ever been told your iron markers look “off,” or that your transferrin saturation is low—even when your diet seems fine? Your TFR2 (Iron) gene helps your liver sense and regulate iron in the body, and understanding your TFR2 genetic variants can clarify why your iron status may trend higher or lower and what nutrition steps may be most appropriate for you.

Key Report Highlights

This DNA report analyzes genetic variants in the TFR2 (Iron) gene and translates them into 3 personalized recommendations tailored to your results. TFR2 encodes transferrin receptor 2, a liver protein that helps bring transferrin-bound iron into liver cells and helps regulate hepcidin—a key hormone that controls how much iron you absorb from food and release from storage. A compelling takeaway: because TFR2 influences hepcidin signaling, it can indirectly affect iron availability for red blood cell production and oxygen transport—two factors closely tied to energy and fatigue.

Personalized, Actionable Recommendations

Your recommendations are personalized to your TFR2 (Iron) genotype, helping you make smarter, safer choices—especially with dietary recommendations. Depending on your results, your report may highlight strategies such as optimizing iron intake from food (e.g., emphasizing heme-iron sources or pairing plant-based iron with vitamin C to support absorption) or guidance on when to be cautious with supplemental iron and prioritize iron-status monitoring with a clinician. The goal is to align your nutrition decisions with your genetic tendencies and your real-world lab context.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The TFR2 (Iron) gene provides instructions for making transferrin receptor 2, a protein found mainly in liver cells. This receptor helps the liver take in iron that’s carried through the blood by transferrin (a transport protein). TFR2 also helps regulate levels of hepcidin, a hormone that acts like a “gatekeeper” for iron—controlling how much iron is absorbed from the diet and how much is released from storage into the bloodstream.
: TFR2 is important because it helps your body sense iron levels and adjust absorption and storage accordingly. Certain genetic variants in TFR2 have been associated with differences in iron-related markers such as transferrin saturation and other measures of iron status. In practical terms, your TFR2 genetics may help explain why you tend toward lower or higher iron availability, which can influence red blood cell development and may contribute to symptoms related to energy and fatigue—especially when combined with diet, life stage (e.g., pregnancy), and overall nutrient status.
: Based on your TFR2 (Iron) results, you’ll receive 3 personalized recommendations focused on dietary guidance. These can include actionable steps such as choosing the most effective food sources of iron for your needs, improving iron absorption through smart nutrient pairing (for example, combining iron-rich foods with vitamin C), and identifying situations where it may be wise to discuss iron labs or supplementation decisions with a healthcare professional. Your report is designed to help you translate genetics into practical next steps, not guesswork.
: Transferrin saturation reflects how much iron is bound to transferrin in the blood and is commonly used to assess iron deficiency or iron overload. TFR2 genetic variants may influence how effectively the liver senses transferrin-bound iron and regulates hepcidin. Because hepcidin controls iron absorption from the diet and iron release from storage, changes in this regulatory pathway can be associated with differences in iron-status markers—such as transferrin saturation and related red blood cell indices. Your report connects your TFR2 genetics to these biological pathways and provides dietary recommendations aligned with your results.
: A TFR2 (Iron) genetic test report translates your DNA into clear, personalized insights for nutrition, energy, and fatigue considerations. It analyzes genetic variants in TFR2, explains what they may imply for iron regulation and iron-status tendencies, and delivers 3 personalized dietary recommendations you can apply in everyday life. The report is designed to be scientifically grounded and easy to understand, helping you make more informed choices about iron-rich foods, absorption-supporting strategies, and when to consider discussing iron markers with a clinician.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.83 out of 5 based on 6 customer ratings

4.8 (7 reviews)

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Travis D.

Rated 5 out of 5
Ottima esperienza, le indicazioni erano subito utili per la mia dieta. Ho scoperto cose che non avevo mai sentito dal mio medico, specie sull’associazione ferro e vitamina C. Consiglio vivamente.
Thiago F.

Rated 5 out of 5
O relatório TFR2 (Iron) me ajudou a organizar uma estratégia real para ferro, sem paranoia. Eu vinha com cansaço e exames oscilando, e sempre ficava na dúvida entre suplementar ou focar na alimentação. As recomendações foram bem claras, aumentar a ingestão de ferro com vitamina C na mesma refeição, priorizar fontes vegetais como feijão, grão de bico e espinafre, e melhorar a absorção evitando café logo após o almoço. Em poucas semanas, notei mais disposição nos treinos e menos sonolência no fim da tarde. Até minha nutricionista achou as sugestões úteis.
David L.

Rated 5 out of 5
The TFR2 (Iron) report made my iron labs make sense for the first time. I’ve had borderline ferritin for years, but I kept guessing whether to push supplements or just eat better. The report explained my genetic angle and gave practical steps, like pairing iron with vitamin C at meals, choosing plant iron sources like lentils and pumpkin seeds, and spacing coffee away from iron-rich foods. Within a month, my afternoon crashes eased and my follow up ferritin ticked up. It felt targeted, not generic nutrition advice.
Tom D.

Rated 5 out of 5
Really appreciated the specific advice about iron and vitamin C, made it easier to plan my meals.
Derek V.

Rated 5 out of 5
Citrus plus iron, finally.

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TFR2 (Iron)

Product features

Understanding Your TFR2 (Iron) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the TFR2 (Iron) gene do?

Why is the TFR2 (Iron) gene important?

What can I do based on my TFR2 (Iron) results?

How can TFR2 (Iron) genetic variants affect transferrin saturation and iron status?

What do I get from a TFR2 (Iron) genetic test report for nutrition and fatigue?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers