What is an oxidative stress test?

An oxidative stress test looks at how well your body handles reactive oxygen species, the damaging byproducts of energy production and immune activity. Most tests measure damage markers in blood or urine at a single point in time. This report takes the genetic route instead: it analyzes 20 genes and 33 variants that shape how much oxidative stress you generate and how quickly you neutralize it. Those results do not change from day to day, so they tell you where to focus long term.

Can a DNA test really measure oxidative stress?

A DNA test measures capacity rather than current damage. Your variants in genes like SOD2, CAT, GPX1, GCLC, and NFE2L2 determine how efficiently each step of antioxidant defense works, which tells you where your defenses are likely strongest and weakest and which nutrients matter most for you. Damage markers such as 8-OHdG and F2-isoprostanes tell you what is happening right now. The two are complementary, which is why this report also lists the lab markers most worth checking for your specific genotype.

What are the symptoms of oxidative stress?

Oxidative stress has no single symptom set, which is part of why it goes unnoticed. People commonly report fatigue, slow recovery from exercise, brain fog, and premature skin aging, but all of these overlap with many other causes. Because oxidative damage accumulates quietly over years, knowing your genetic antioxidant capacity and checking objective markers is far more reliable than reading symptoms.

Which genes affect oxidative stress?

The core antioxidant enzymes come from SOD2 and SOD3 (superoxide clearance), CAT, GPX1, and GPX4 (peroxide clearance), and GCLC and GSR (glutathione production and recycling), all coordinated by NFE2L2, the NRF2 master switch. Detox genes NQO1, GSTP1, GSTA1, PON1, and HMOX1 clear reactive byproducts before they add to the load. NOS3 and MPO influence how much oxidative burden you generate in the first place, while MTHFR, COMT, APOE, FOXO3, and UCP2 shape the longer-term picture. This report covers all 20.

How can I reduce oxidative stress?

The best-researched approaches are eating more polyphenol-rich and sulforaphane-rich plants, exercising aerobically on a regular basis (which trains your own antioxidant enzymes through mild, repeated stress), keeping iron in a healthy range rather than high, and limiting alcohol, pesticide, and mycotoxin exposure. More targeted support such as NAC, glutathione, selenium, or CoQ10 depends on which step of your pathway is weakest, and identifying that step is what this report is for.

What are the best supplements for oxidative stress?

There is no single best supplement, because different variants call for different support. Sulforaphane and green tea extract activate NRF2. NAC and glutathione address low glutathione synthesis. Selenium is required by the glutathione peroxidase enzymes, manganese supports SOD2, and copper and zinc support SOD3. CoQ10 and vitamin E protect membrane lipids. Your report ranks these for your own genotype and gives typical starting doses. Talk to your healthcare provider before starting supplements, especially if you take medication.

Which lab markers show oxidative stress?

The most direct markers are 8-OHdG for DNA damage, F2-isoprostanes and malondialdehyde for lipid peroxidation, oxidized LDL, and total or reduced-to-oxidized glutathione. Useful supporting markers include GGT, homocysteine, hs-CRP, iron and ferritin, selenium, manganese, copper, and mercury. This report tells you which of these are most informative for your genotype and lets you enter your results directly next to the pathway.

How much does an oxidative stress test cost?

The Oxidative Stress Pathway report is $99, down from $199. You will also need a SelfDecode DNA kit if you do not already have one. Conventional oxidative stress lab panels typically run well above this and only capture a single point in time.

Where can I get an oxidative stress test?

You can order this report here and do everything from home. Conventional oxidative stress panels are usually ordered through a functional medicine practitioner or a direct-to-consumer lab.

How is this different from the Mitochondrial Health & Energy Pathway report?

They overlap on purpose but answer different questions. The mitochondrial report is about how your cells make energy: fuel metabolism, NAD+, CoQ10 production, ATP output, and mitochondrial renewal. This report is about the damage side: how much oxidative stress you produce, and how well you neutralize and detox it. Seven genes appear in both panels (SOD2, GPX1, GPX4, NQO1, NFE2L2, FOXO3, and UCP2), so running the two together gives you the full picture of energy production and cellular protection.

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Oxidative Stress & Antioxidant Defense Pathway - NRF2, SOD2 & 18 More Genes

Oxidative Stress & Antioxidant Defense Pathway - NRF2, SOD2 & 18 More Genes

See how your genes shape your body's antioxidant defenses, from how much oxidative stress you generate to how quickly you neutralize it, recycle glutathione, and clear the toxins and oxidized fats that add to the load. View sample report.

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Oxidative Stress & Antioxidant Defense Pathway – NRF2, SOD2 & 18 More Genes

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Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understand your body’s antioxidant defenses

Oxidative stress is not something you either have or do not have. It is a running balance between the reactive oxygen species your cells produce and the enzymes that neutralize them. This report analyzes 20 genes and 33 variants across every stage of that balance, so you can see where your own defenses are strong, where they lag, and what to do about it.

Your results show:

How much oxidative burden your body generates in the first place
How quickly you clear superoxide and hydrogen peroxide
How well you produce and recycle glutathione, your master antioxidant
How strongly your NRF2 antioxidant response switches on
How efficiently you detox toxins, pollutants, and oxidized fats
How your methylation and lipid-clearance genes add to or ease the load

Two pathway maps, not just a gene list

Two visual diagrams place every gene and variant at the exact biochemical step where it acts, color-coded for typical, altered, or better activity, with arrows showing which direction your variant pushes that step. You can also enter your own bloodwork alongside the pathway compounds, including homocysteine, 8-OHdG, oxLDL, and glutathione, to see whether your measured physiology matches what your genetics predict.

What Genes Are Tested in the Oxidative Stress Pathway Panel?

20 genes and 33 variants across 8 connected steps of the pathway.

ROS generation (2 genes): NOS3, MPO
Superoxide clearance (2 genes): SOD2, SOD3
Peroxide and lipid peroxide clearance (3 genes): CAT, GPX1, GPX4
Glutathione production and recycling (2 genes): GCLC, GSR
Master antioxidant regulation (2 genes): NFE2L2 (NRF2), FOXO3
Detoxification (5 genes): NQO1, GSTP1, GSTA1, PON1, HMOX1
Methylation and homocysteine clearance (2 genes): MTHFR, COMT
Long-term lipid and cellular protection (2 genes): APOE, UCP2

Why Choose SelfDecode’s Oxidative Stress Pathway?

20 genes and 33 variants analyzed across 8 sub-pathways
Two visual pathway diagrams with your own genotypes mapped in place
A plain-language explanation of every gene and what your variant means
Personalized diet, lifestyle, and supplement recommendations, ranked by impact
A personalized list of lab markers to check, organized by the gene that makes each one relevant
Science-Driven: Recommendations backed by the latest methylation research.
Easy to Implement: Clear, practical steps to help you make real improvements to your health.
Secure & Private: Your data is protected and compliant with HIPAA & GDPR standards.

: Reactive oxygen species are normal byproducts of energy production and immune activity. The problem starts when they outpace your antioxidant capacity. Left unchecked they damage DNA, proteins, and cell membranes, and research links that damage to accelerated aging, chronic inflammation, cardiovascular disease, neurodegeneration, and cancer. Antioxidant defense runs as a chain, so the weakest step sets your ceiling. Strong superoxide dismutase activity paired with weak peroxide clearance can raise oxidative stress rather than lower it, because hydrogen peroxide then builds up faster than it is cleared. Reading your genes as a system, instead of one at a time, is what makes the result actionable.
: Every recommendation is ranked by likely impact for your specific variants, names the genes it applies to, and explains the mechanism behind it. Diet: cruciferous vegetables and sulforaphane, dietary polyphenols, nitrate-rich greens, extra virgin olive oil, glycine, folate, and iron and copper intake matched to your variants Supplements: NAC, glutathione, selenium, CoQ10, curcumin, green tea extract, vitamin E, riboflavin, choline, pomegranate, and omega-3, with typical starting doses Lifestyle: aerobic exercise as hormetic training for your own antioxidant enzymes, plus reducing pesticide, mycotoxin, and heavy metal exposure where your detox genes are weaker

Product FAQs

: An oxidative stress test looks at how well your body handles reactive oxygen species, the damaging byproducts of energy production and immune activity. Most tests measure damage markers in blood or urine at a single point in time. This report takes the genetic route instead: it analyzes 20 genes and 33 variants that shape how much oxidative stress you generate and how quickly you neutralize it. Those results do not change from day to day, so they tell you where to focus long term.
: A DNA test measures capacity rather than current damage. Your variants in genes like SOD2, CAT, GPX1, GCLC, and NFE2L2 determine how efficiently each step of antioxidant defense works, which tells you where your defenses are likely strongest and weakest and which nutrients matter most for you. Damage markers such as 8-OHdG and F2-isoprostanes tell you what is happening right now. The two are complementary, which is why this report also lists the lab markers most worth checking for your specific genotype.
: Oxidative stress has no single symptom set, which is part of why it goes unnoticed. People commonly report fatigue, slow recovery from exercise, brain fog, and premature skin aging, but all of these overlap with many other causes. Because oxidative damage accumulates quietly over years, knowing your genetic antioxidant capacity and checking objective markers is far more reliable than reading symptoms.
: The core antioxidant enzymes come from SOD2 and SOD3 (superoxide clearance), CAT, GPX1, and GPX4 (peroxide clearance), and GCLC and GSR (glutathione production and recycling), all coordinated by NFE2L2, the NRF2 master switch. Detox genes NQO1, GSTP1, GSTA1, PON1, and HMOX1 clear reactive byproducts before they add to the load. NOS3 and MPO influence how much oxidative burden you generate in the first place, while MTHFR, COMT, APOE, FOXO3, and UCP2 shape the longer-term picture. This report covers all 20.
: The best-researched approaches are eating more polyphenol-rich and sulforaphane-rich plants, exercising aerobically on a regular basis (which trains your own antioxidant enzymes through mild, repeated stress), keeping iron in a healthy range rather than high, and limiting alcohol, pesticide, and mycotoxin exposure. More targeted support such as NAC, glutathione, selenium, or CoQ10 depends on which step of your pathway is weakest, and identifying that step is what this report is for.
: There is no single best supplement, because different variants call for different support. Sulforaphane and green tea extract activate NRF2. NAC and glutathione address low glutathione synthesis. Selenium is required by the glutathione peroxidase enzymes, manganese supports SOD2, and copper and zinc support SOD3. CoQ10 and vitamin E protect membrane lipids. Your report ranks these for your own genotype and gives typical starting doses. Talk to your healthcare provider before starting supplements, especially if you take medication.
: The most direct markers are 8-OHdG for DNA damage, F2-isoprostanes and malondialdehyde for lipid peroxidation, oxidized LDL, and total or reduced-to-oxidized glutathione. Useful supporting markers include GGT, homocysteine, hs-CRP, iron and ferritin, selenium, manganese, copper, and mercury. This report tells you which of these are most informative for your genotype and lets you enter your results directly next to the pathway.
: The Oxidative Stress Pathway report is $99, down from $199. You will also need a SelfDecode DNA kit if you do not already have one. Conventional oxidative stress lab panels typically run well above this and only capture a single point in time.
: You can order this report here and do everything from home. Conventional oxidative stress panels are usually ordered through a functional medicine practitioner or a direct-to-consumer lab.
: They overlap on purpose but answer different questions. The mitochondrial report is about how your cells make energy: fuel metabolism, NAD+, CoQ10 production, ATP output, and mitochondrial renewal. This report is about the damage side: how much oxidative stress you produce, and how well you neutralize and detox it. Seven genes appear in both panels (SOD2, GPX1, GPX4, NQO1, NFE2L2, FOXO3, and UCP2), so running the two together gives you the full picture of energy production and cellular protection.

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This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

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Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

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We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

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Oxidative Stress & Antioxidant Defense Pathway - NRF2, SOD2 & 18 More Genes

Product features

Understand your body’s antioxidant defenses

Two pathway maps, not just a gene list

What Genes Are Tested in the Oxidative Stress Pathway Panel?

Why Choose SelfDecode’s Oxidative Stress Pathway?

Why oxidative stress matters?

What makes this report unique?

Product FAQs

What is an oxidative stress test?

Can a DNA test really measure oxidative stress?

What are the symptoms of oxidative stress?

Which genes affect oxidative stress?

How can I reduce oxidative stress?

What are the best supplements for oxidative stress?

Which lab markers show oxidative stress?

How much does an oxidative stress test cost?

Where can I get an oxidative stress test?

How is this different from the Mitochondrial Health & Energy Pathway report?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading
Scientists & Engineers

Reviews

Oxidative Stress & Antioxidant Defense Pathway - NRF2, SOD2 & 18 More Genes

Product features

Understand your body’s antioxidant defenses

Two pathway maps, not just a gene list

What Genes Are Tested in the Oxidative Stress Pathway Panel?

Why Choose SelfDecode’s Oxidative Stress Pathway?

Why oxidative stress matters?

What makes this report unique?

Product FAQs

What is an oxidative stress test?

Can a DNA test really measure oxidative stress?

What are the symptoms of oxidative stress?

Which genes affect oxidative stress?

How can I reduce oxidative stress?

What are the best supplements for oxidative stress?

Which lab markers show oxidative stress?

How much does an oxidative stress test cost?

Where can I get an oxidative stress test?

How is this different from the Mitochondrial Health & Energy Pathway report?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers