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Methylation Pathway – MTHFR Test

Understand how your genetic methylation pathway impacts key processes in your body, from detoxification to brain function. Get personalized recommendations to optimize methylation. View sample report.
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Overall methylation ability
Folate cycle, Methionine cycle and Transsulfuration
23 genes we look at
DNA-based, science-backed recommendations

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Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

 

Optimize Your Methylation: A Key to Better Health

Are you concerned that your body may not be efficiently processing essential nutrients like folate, vitamin B12, and choline? Could genetic variations be hindering your energy levels, brain function, or detoxification pathways? Are you at risk of imbalances that impact cardiovascular health, mental well-being, or inflammation? A genetic methylation test can help uncover how your body processes these critical nutrients and reveal where support may be needed to optimize your health.

 

Understanding Methylation

Your Methylation Pathways Genetic Report, based on a specialized DNA test, reveals the genetic factors influencing these vital biochemical processes. Methylation is essential for:

  • Detoxification
  • Hormone regulation
  • Neurotransmitter synthesis
  • Energy production
  • Inflammation control
  • Homocysteine metabolism
  • Protein methylation
  • Liver detoxification
  • Immune system support
  • DNA repair

Methylation is crucial in understanding autoimmune and neurological disorders, such as multiple sclerosis, seizure disorders, dementia, chronic fatigue syndrome, lupus, depression, anxiety, and autism spectrum disorders. While this complex process occurs in every cell, as well as in brain fluids and the liver, it impacts many vital bodily functions.

 

The Importance of Healthy Methylation

When methylation is impaired, it can contribute to birth defects, depression, cognitive decline, and even cancer. Research has also linked inadequate methylation to autism. Supporting methylation pathways has been associated with improvements in speech development, behavior, and attention-related disorders like ADD and ADHD.

 

Personalized Insights and Recommendations

With this report, you’ll gain personalized insights into how your genes impact methylation and receive clear, actionable recommendations on:

  • Dietary strategies: Optimize your intake of methylation-supporting nutrients like folate, vitamin B6, and B12.
  • Supplement recommendations: Understand which vitamins, minerals, and cofactors may help improve your methylation function.
  • Lifestyle adjustments: Learn how environmental factors, stress, and toxins influence your genetic pathways and how to mitigate risks.

 

Key Methylation Cycles

This report evaluates your overall methylation capacity and outlines three key cycles within a single Methylation Pathway Diagram:

  1. Folate Cycle: CUBN, DHFR, FOLH1, FUT2, MTHFD1, MTHFD1L, MTHFR, MTHFS, MTR, MTRR, SHMT1, TCN2, TYMS
  2. Methionine Cycle: AHCY, BHMT, CHDH, COMT, DNMT3B, GNMT, MAT1A, PEMT
  3. Transsulfuration: CBS, PDXK

 

Why Choose This Report?

  • Personalized to You: No one-size-fits-all advice; tailored insights based on your unique DNA.
  • Science-Driven: Recommendations backed by the latest methylation research.
  • Easy to Implement: Clear, practical steps to help you make real improvements to your health.
  • Secure & Private: Your data is protected and compliant with HIPAA & GDPR standards.

Take control of your health, longevity, and vitality with genetic insights designed to support optimal methylation – because when your methylation is balanced, your entire body functions better.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

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  1. Jule

    With a background of unexplained mood swings and depression, this report was a turning point. It outlined how variations in my DHFR and PRDX1 genes might impact my folate metabolism. The actionable advice to adjust my diet and supplement with methylfolate and antioxidants has profoundly improved my mental well being. The detailed but accessible explanations turned confusing science into clear guidance.

  2. Marius

    Dealing with anxiety for years, the report’s analysis of my COMT Val158Met variant was eye opening. It explained why I metabolize stress hormones differently and gave specific recommendations, including magnesium supplementation and lifestyle adjustments. Since following these, I’ve experienced calmer moods and better stress management. As a 29 year old graphic designer, this personalized insight was invaluable.

  3. Natasha

    As a mom of two with a family history of cardiovascular issues, I wanted to be proactive. This Methylation Pathway report illuminated my MTHFR and MTRR variants and their implications for homocysteine metabolism. The clear supplement and diet suggestions helped me start a regimen with methylfolate and betaine. I now feel confident I’m reducing my risk factors and setting a healthy example for my kids.

  4. Catherine

    I’ve struggled with chronic fatigue for years and always suspected a genetic component. This report highlighted my CBS gene variant and explained why sulfur containing foods triggered symptoms. The personalized advice to moderate my intake and increase B6 (PLP) support has made a noticeable difference in my energy. I’m a 42 year old teacher, and this report gave me practical steps that my doctor and I could implement immediately.

  5. Lynette

    As a 35 year old biohacker, I was thrilled to receive the Methylation Pathway report. It provided an intricate analysis of my MTHFR C677T and MTR variants, clearly outlining how these affect my ability to process folate and B12. The report’s recommendations for supplementing with methylfolate and adenosyl cobalamin have significantly enhanced my mental clarity and endurance during workouts. The visual methylation pathway made complex genetics understandable and actionable.

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