Save $150

Methylation Pathway – MTHFR Test

Understand how your genetic methylation pathway impacts key processes in your body, from detoxification to brain function. Get personalized recommendations to optimize methylation. View sample report.
$299
$149
Save $150
Proven track record: 3+ million analyses delivered

Trusted by 200,000+ users & 2,000+ doctors

Proven track record: 3+ million analyses delivered

Overall methylation ability
Folate cycle, Methionine cycle and Transsulfuration
23 genes we look at
DNA-based, science-backed recommendations

Product features

 

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

 

Optimize Your Methylation: A Key to Better Health

Are you concerned that your body may not be efficiently processing essential nutrients like folate, vitamin B12, and choline? Could genetic variations be hindering your energy levels, brain function, or detoxification pathways? Are you at risk of imbalances that impact cardiovascular health, mental well-being, or inflammation? A genetic methylation test can help uncover how your body processes these critical nutrients and reveal where support may be needed to optimize your health.

 

What Is a Genetic Methylation Test?

Your Methylation Pathways Genetic Report, based on a specialized DNA test, reveals the genetic factors influencing these vital biochemical processes. Methylation is essential for:

  • Detoxification
  • Hormone regulation
  • Neurotransmitter synthesis
  • Energy production
  • Inflammation control
  • Homocysteine metabolism
  • Protein methylation
  • Liver detoxification
  • Immune system support
  • DNA repair

Methylation is crucial in understanding autoimmune and neurological disorders, such as multiple sclerosis, seizure disorders, dementia, chronic fatigue syndrome, lupus, depression, anxiety, and autism spectrum disorders. While this complex process occurs in every cell, as well as in brain fluids and the liver, it impacts many vital bodily functions.

 

The Importance of Healthy Methylation

When methylation is impaired, it can contribute to birth defects, depression, cognitive decline, and even cancer. Research has also linked inadequate methylation to autism. Supporting methylation pathways has been associated with improvements in speech development, behavior, and attention-related disorders like ADD and ADHD.

 

Personalized Insights and Recommendations, Best Supplements for MTHFR Mutations

With this report, you’ll gain personalized insights into how your genes impact methylation and receive clear, actionable recommendations on:

  • Dietary strategies: Optimize your intake of methylation-supporting nutrients like folate, vitamin B6, and B12.
  • Supplement recommendations: Understand which vitamins, minerals, and cofactors may help improve your methylation function.
  • Lifestyle adjustments: Learn how environmental factors, stress, and toxins influence your genetic pathways and how to mitigate risks.

 

What Genes Are Tested in the Methylation Pathway Panel?

SelfDecode’s Methylation Pathway report is a comprehensive genetic methylation test that analyzes key genes involved in your methylation cycle. This report evaluates your overall methylation capacity and outlines three key cycles within a single Methylation Pathway Diagram:

  1. Folate Cycle: CUBN, DHFR, FOLH1, FUT2, MTHFD1, MTHFD1L, MTHFR, MTHFS, MTR, MTRR, SHMT1, TCN2, TYMS
  2. Methionine Cycle: AHCY, BHMT, CHDH, COMT, DNMT3B, GNMT, MAT1A, PEMT
  3. Transsulfuration: CBS, PDXK

 

Why Choose SelfDecode’s Methylation Test?

Unlike a standard homocysteine blood test that only shows a single snapshot, our DNA methylation test reveals the genetic root causes of methylation dysfunction.

Whether you are investigating signs of MTHFR gene mutation, looking for the best methylation supplements, or want to understand your methylation deficiency risk, SelfDecode provides personalized, science-backed insights you can act on. Our at-home methylation test delivers results with targeted supplement and lifestyle recommendations based on your unique genetic profile.

Recommended by health practitioners and aligned with the latest research on methylation and anxiety, depression, cardiovascular health, and fertility, SelfDecode’s methylation genetic test is the most comprehensive at-home option available.

  • Personalized to You: No one-size-fits-all advice; tailored insights based on your unique DNA.
  • Science-Driven: Recommendations backed by the latest methylation research.
  • Easy to Implement: Clear, practical steps to help you make real improvements to your health.
  • Secure & Private: Your data is protected and compliant with HIPAA & GDPR standards.

Take control of your health, longevity, and vitality with genetic insights designed to support optimal methylation – because when your methylation is balanced, your entire body functions better.

Product FAQs

WHY SELFDECODE?

Reviews

4.6 (14 reviews)
5
10
4
3
3
1
2
0
1
0
Share your thoughts

If you've used this product, share your thoughts with other customers

Only customers who purchased this product can leave reviews
  1. John

    I found the Methylation Pathway report to be quite informative and it gave me a better understanding of my genetic predispositions regarding methylation. The detailed analysis helped me make some lifestyle changes that I believe are beneficial. However, the experience was somewhat disappointing overall. The wait time to receive the report was much longer than I expected, which was frustrating as I was eager to get the information. Additionally, I felt the pricing was a bit steep

  2. Steven

    This report gave me fantastic insights into my methylation pathway, helping me identify areas where my body isn’t processing nutrients efficiently. As a healthcare professional, I value scientific accuracy and actionable data, and this report delivered on both fronts. The pathways were clearly illustrated, making it easier to explain to my patients as well. The supplement recommendations were helpful, though I do wish there were more specific brand suggestions included to make purchasing easier. Overall, a great tool to better understand my genetic health.

  3. Torstein

    I found this Methylation Pathway report to be very comprehensive and easy to understand despite the scientific complexity. It helped me figure out why I might have low energy and issues related to homocysteine metabolism, providing explanations that made the biochemistry accessible. The dietary recommendations were practical and tailored, which I appreciated. The only downside was that it took 3 weeks to receive the results, which felt a bit long. Still, the quality of the information made the wait worthwhile.

  4. Nicky

    The Methylation Pathway report provided me with an incredible amount of detailed information about my genetic methylation processes. As someone who has struggled with folate metabolism issues, the report helped me understand what specific supplements and dietary changes I need to focus on. I loved the clarity of the explanations and how the results were broken down into actionable insights. My only wish is that there was a mobile app available, as I prefer to review such health information on the go. Otherwise, an excellent resource for anyone interested in genetic health.