What does the DIO1 (Thyroid) gene do?

The DIO1 (Thyroid) gene provides instructions for making an enzyme called type 1 iodothyronine deiodinase. This enzyme helps convert T4 (thyroxine) into T3 (triiodothyronine), the more active thyroid hormone your cells use for many metabolic functions. DIO1 also helps break down and regulate levels of both T3 and T4, supporting balanced thyroid hormone activity. Because DIO1 works as a selenium-dependent enzyme, adequate selenium availability is important for optimal function.

Why is the DIO1 (Thyroid) gene important?

DIO1 (Thyroid) is important because it influences how much active T3 your body can produce from T4. Certain genetic variants are associated with reduced DIO1 expression and lower T3 levels. This matters because some people can experience hypothyroid-like symptoms—such as low energy, sluggish metabolism, or brain fog—despite having normal or even slightly elevated T4 on standard labs. Understanding your DIO1 genetic variants helps explain individual differences in thyroid hormone activation and can guide more personalized support strategies.

What can I do based on my DIO1 (Thyroid) results?

Based on your DIO1 (Thyroid) results, you’ll receive 6 personalized recommendations focused on actionable lifestyle and supplement guidance. These recommendations are tailored to your genotype and may include targeted nutrient support relevant to DIO1’s selenium-dependent function, plus practical lifestyle strategies that support thyroid hormone balance and day-to-day energy. Your report is designed to help you prioritize the most relevant next steps based on how your genetics may affect T4-to-T3 conversion.

Can DIO1 genetic variants affect T3 levels and hypothyroidism symptoms?

Yes. Research links certain DIO1 genetic variants (including commonly studied markers such as rs2235544) with lower circulating T3, the active thyroid hormone. Reduced DIO1 expression can mean less conversion of T4 into T3, which may contribute to hypothyroidism-like symptoms in some individuals—even when T4 appears normal or slightly elevated. A DIO1-focused DNA report helps you understand whether your genetics may predispose you to lower active T3 and provides personalized strategies to support thyroid hormone activation.

What is included in a DIO1 (Thyroid) genetic test report?

A DIO1 (Thyroid) genetic test report typically includes analysis of relevant genetic variants associated with thyroid hormone conversion and regulation, an easy-to-understand explanation of what your genotype may mean for T4-to-T3 activation, and 6 personalized recommendations. In this report, recommendations include lifestyle and supplement guidance, designed to be practical and tailored to your DNA—so you can make informed choices that align with how your body may process thyroid hormones.

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DIO1 (Thyroid)

Rated 4.67 out of 5 based on 12 customer ratings

4.7 (13 reviews)

DIO1 (Thyroid)

Rated 4.67 out of 5 based on 12 customer ratings

4.7 (13 reviews)

The report provides up to 6 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Trusted by 200,000+ users & 2,000+ doctors

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Analyzes Key Genetic Variants

Up to 6 DNA-Based, Science-Backed Recommendations

DIO1 (Thyroid)

$59 $29

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Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your DIO1 (Thyroid) Variants: A DNA Gene Report

Do you ever feel tired, foggy, or “off” even when your thyroid labs look mostly normal? Have you wondered why your energy, metabolism, or temperature sensitivity doesn’t match what you’d expect? Your DIO1 (Thyroid) gene helps control how efficiently your body converts thyroid hormone into its active form—so understanding your DIO1 genetic variants can reveal why you may be more prone to low active T3 and hypothyroid-like symptoms.

Key Report Highlights

This DIO1 (Thyroid) Gene Report analyzes key genetic variants linked to thyroid hormone conversion and provides 6 personalized recommendations tailored to your DNA. DIO1 encodes an enzyme (a selenium-dependent “selenoenzyme”) that helps convert T4 into T3—the active thyroid hormone that influences energy production, heart function, alertness, breathing rate, bone growth, and reproductive health. A compelling takeaway: when DIO1 activity is reduced, T3 can run lower even if T4 looks normal or slightly elevated—potentially contributing to hypothyroidism-like symptoms.

Personalized, Actionable Recommendations

Your results translate into clear, actionable guidance based on your DIO1 (Thyroid) genotype, with personalized lifestyle and supplement recommendations designed to support healthy thyroid hormone activation. For example, your plan may include targeted nutrition strategies to support selenium-dependent enzyme function, or lifestyle adjustments that help reduce factors that may worsen low-T3 symptoms (such as inconsistent sleep timing or high stress load). Each recommendation is tailored to your genetic profile so you can focus on the actions most relevant to how your body processes thyroid hormones.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The DIO1 (Thyroid) gene provides instructions for making an enzyme called type 1 iodothyronine deiodinase. This enzyme helps convert T4 (thyroxine) into T3 (triiodothyronine), the more active thyroid hormone your cells use for many metabolic functions. DIO1 also helps break down and regulate levels of both T3 and T4, supporting balanced thyroid hormone activity. Because DIO1 works as a selenium-dependent enzyme, adequate selenium availability is important for optimal function.
: DIO1 (Thyroid) is important because it influences how much active T3 your body can produce from T4. Certain genetic variants are associated with reduced DIO1 expression and lower T3 levels. This matters because some people can experience hypothyroid-like symptoms—such as low energy, sluggish metabolism, or brain fog—despite having normal or even slightly elevated T4 on standard labs. Understanding your DIO1 genetic variants helps explain individual differences in thyroid hormone activation and can guide more personalized support strategies.
: Based on your DIO1 (Thyroid) results, you’ll receive 6 personalized recommendations focused on actionable lifestyle and supplement guidance. These recommendations are tailored to your genotype and may include targeted nutrient support relevant to DIO1’s selenium-dependent function, plus practical lifestyle strategies that support thyroid hormone balance and day-to-day energy. Your report is designed to help you prioritize the most relevant next steps based on how your genetics may affect T4-to-T3 conversion.
: Yes. Research links certain DIO1 genetic variants (including commonly studied markers such as rs2235544) with lower circulating T3, the active thyroid hormone. Reduced DIO1 expression can mean less conversion of T4 into T3, which may contribute to hypothyroidism-like symptoms in some individuals—even when T4 appears normal or slightly elevated. A DIO1-focused DNA report helps you understand whether your genetics may predispose you to lower active T3 and provides personalized strategies to support thyroid hormone activation.
: A DIO1 (Thyroid) genetic test report typically includes analysis of relevant genetic variants associated with thyroid hormone conversion and regulation, an easy-to-understand explanation of what your genotype may mean for T4-to-T3 activation, and 6 personalized recommendations. In this report, recommendations include lifestyle and supplement guidance, designed to be practical and tailored to your DNA—so you can make informed choices that align with how your body may process thyroid hormones.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.67 out of 5 based on 12 customer ratings

4.7 (13 reviews)

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Carter N.

Rated 3 out of 5
Useful DIO1 overview, but the NAC section felt a bit salesy and I wanted clearer lab follow-up suggestions for thyroid monitoring.
Luna B.

Rated 4 out of 5
Selenium clarified my sluggish thyroid.
Pablo D.

Rated 5 out of 5
Muy satisfecho con los resultados, me ayudó a entender mejor mi salud tiroidea y ahora sé qué evitar en mi dieta. Lo mostré a mi endocrino y le pareció útil también.
Santiago A.

Rated 5 out of 5
I brought the dio1 thyroid results to my integrative doc and she was genuinely impressed with the depth. She said it gave her extra insight into why my T4-T3 conversion has always been tricky for me. We tweaked my supplements based on the gene info, and she found it a really useful addition alongside my labs.
Rebecca Y.

Rated 4 out of 5
Honestly, I didn’t really trust DNA health stuff before, but the guidance around avoiding pesticides and adding selenium actually made sense for my thyroid issues. I just wish there had been a little more info about how much selenium or which brands they recommend.

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DIO1 (Thyroid)

Product features

Understanding Your DIO1 (Thyroid) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the DIO1 (Thyroid) gene do?

Why is the DIO1 (Thyroid) gene important?

What can I do based on my DIO1 (Thyroid) results?

Can DIO1 genetic variants affect T3 levels and hypothyroidism symptoms?

What is included in a DIO1 (Thyroid) genetic test report?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers