What does the MTNR1A (Melatonin) gene do?

MTNR1A is the gene that provides instructions for building the melatonin receptor 1A (MT1). Think of MT1 as a cellular “antenna” that receives the melatonin signal—especially in the brain—to help regulate circadian rhythm and support sleep timing. When melatonin binds to MT1, it helps coordinate night-time physiology and influences processes tied to sleep and biological timing.

Why is the MTNR1A (Melatonin) gene important?

MTNR1A is important because genetic variants can influence how many MT1 receptors you have (gene expression) or how well the receptor functions. Research has linked specific MTNR1A variants to differences in sleep-related outcomes and circadian resilience (for example in shift workers), as well as associations with blood sugar control (including gestational diabetes risk patterns), cognitive aging, kidney stones or kidney-related traits, and risk signals seen in certain cancers. Your report helps interpret these findings in a personalized, DNA-based way.

What can I do based on my MTNR1A (Melatonin) results?

Based on your MTNR1A results, you’ll receive 6 personalized recommendations focused on lifestyle and supplement actions. These may include guidance on circadian-supportive habits (like consistent sleep/wake timing, managing evening light exposure, and timing of meals or exercise) and supplement considerations (such as melatonin timing/dose considerations or supportive alternatives) tailored to your genotype. The goal is to turn your MTNR1A genetic insights into practical next steps you can discuss with your healthcare professional and apply to daily routines.

Can MTNR1A (melatonin receptor) variants affect blood sugar and diabetes risk?

They may. MTNR1A encodes the MT1 melatonin receptor, and melatonin signaling is part of the body’s circadian system—an upstream regulator of metabolic timing. In research, the MTNR1A variant rs2119882 (C allele), which may reduce MTNR1A gene expression and lower MT1 receptor levels, has been associated with increased risk and severity signals for conditions including gestational diabetes and PCOS in certain study populations. While genetics is not destiny, knowing your MTNR1A pattern can help you prioritize circadian-aligned habits (sleep consistency, light timing, and meal timing) that support healthier glucose regulation.

What SNPs are included in MTNR1A genetic testing in this DNA report?

This MTNR1A Gene Report analyzes 5 SNPs highlighted in the scientific literature for potential effects on MTNR1A expression or MT1 receptor function and for associations with health outcomes. These include rs2119882 (often discussed for effects on gene expression and associations with PCOS/gestational diabetes and certain cancer patterns), rs12506228 (linked in studies to shift-work exhaustion and cognitive aging traits), rs13140012 (associated in research with kidney stones and oral cancer outcomes in specific exposure contexts), rs6553010 (linked to urothelial carcinoma risk patterns and pain outcomes, with mixed findings for kidney stone risk), and rs7665392 (associated in one study with breast cancer risk in premenopausal women). Your report explains what your genotype may imply and provides personalized, actionable lifestyle and supplement recommendations.

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MTNR1A (Melatonin)

Rated 4.89 out of 5 based on 9 customer ratings

4.9 (10 reviews)

MTNR1A (Melatonin)

Rated 4.89 out of 5 based on 9 customer ratings

4.9 (10 reviews)

The report provides up to 6 personalized recommendations based on 5 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Trusted by 200,000+ users & 2,000+ doctors

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Analyzes 5 Genetic Variants

Up to 6 DNA-Based, Science-Backed Recommendations

MTNR1A (Melatonin)

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Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your MTNR1A (Melatonin) Variants: A DNA Gene Report

Do you ever feel wired at night but tired in the morning—especially after late light exposure or shift-work schedules? Have you wondered why sleep changes can also affect your mood, focus, or even blood sugar? Your MTNR1A (Melatonin) gene helps determine how strongly your body “hears” melatonin’s signal, and understanding your MTNR1A variants can clarify why certain routines, supplements, or sleep strategies work well for some people but not others.

Key Report Highlights

This MTNR1A (Melatonin) Gene Report analyzes 5 research-backed genetic variants (SNPs) and translates your results into 6 personalized recommendations. MTNR1A encodes the MT1 melatonin receptor—a key “signal receiver” for melatonin that helps coordinate circadian rhythms and sleep timing. Compellingly, MTNR1A activity has also been linked in studies to blood sugar regulation, learning and memory, kidney health, and risk patterns seen in select cancer types—making it a gene with influence far beyond bedtime.

Personalized, Actionable Recommendations

Your recommendations are tailored to your MTNR1A genotype, because different variants may affect MT1 receptor expression or function—and that can change how your body responds to melatonin signaling, light exposure, and daily timing. You’ll receive lifestyle and supplement guidance aligned to your results, with 6 personalized recommendations designed to be practical and actionable. Examples of the kinds of advice you may see include: timing strategies for light (morning light exposure and evening light reduction) to better support circadian alignment, or individualized considerations around melatonin use (such as whether timing, dose range, or alternatives may be more appropriate given your genetic pattern).

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: MTNR1A is the gene that provides instructions for building the melatonin receptor 1A (MT1). Think of MT1 as a cellular “antenna” that receives the melatonin signal—especially in the brain—to help regulate circadian rhythm and support sleep timing. When melatonin binds to MT1, it helps coordinate night-time physiology and influences processes tied to sleep and biological timing.
: MTNR1A is important because genetic variants can influence how many MT1 receptors you have (gene expression) or how well the receptor functions. Research has linked specific MTNR1A variants to differences in sleep-related outcomes and circadian resilience (for example in shift workers), as well as associations with blood sugar control (including gestational diabetes risk patterns), cognitive aging, kidney stones or kidney-related traits, and risk signals seen in certain cancers. Your report helps interpret these findings in a personalized, DNA-based way.
: Based on your MTNR1A results, you’ll receive 6 personalized recommendations focused on lifestyle and supplement actions. These may include guidance on circadian-supportive habits (like consistent sleep/wake timing, managing evening light exposure, and timing of meals or exercise) and supplement considerations (such as melatonin timing/dose considerations or supportive alternatives) tailored to your genotype. The goal is to turn your MTNR1A genetic insights into practical next steps you can discuss with your healthcare professional and apply to daily routines.
: They may. MTNR1A encodes the MT1 melatonin receptor, and melatonin signaling is part of the body’s circadian system—an upstream regulator of metabolic timing. In research, the MTNR1A variant rs2119882 (C allele), which may reduce MTNR1A gene expression and lower MT1 receptor levels, has been associated with increased risk and severity signals for conditions including gestational diabetes and PCOS in certain study populations. While genetics is not destiny, knowing your MTNR1A pattern can help you prioritize circadian-aligned habits (sleep consistency, light timing, and meal timing) that support healthier glucose regulation.
: This MTNR1A Gene Report analyzes 5 SNPs highlighted in the scientific literature for potential effects on MTNR1A expression or MT1 receptor function and for associations with health outcomes. These include rs2119882 (often discussed for effects on gene expression and associations with PCOS/gestational diabetes and certain cancer patterns), rs12506228 (linked in studies to shift-work exhaustion and cognitive aging traits), rs13140012 (associated in research with kidney stones and oral cancer outcomes in specific exposure contexts), rs6553010 (linked to urothelial carcinoma risk patterns and pain outcomes, with mixed findings for kidney stone risk), and rs7665392 (associated in one study with breast cancer risk in premenopausal women). Your report explains what your genotype may imply and provides personalized, actionable lifestyle and supplement recommendations.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

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Rated 4.89 out of 5 based on 9 customer ratings

4.9 (10 reviews)

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Eric B.

Rated 5 out of 5
I work rotating shifts, and my sleep was a mess. The MTNR1A (Melatonin) report explained why I seem extra sensitive to light at night, and it gave me a simple plan. I started wearing blue blocking glasses after dinner, dimmed my apartment lights, and committed to a regular sleep schedule even on days off. I also tried a low dose melatonin exactly as suggested, timed earlier than I used to take it. Within two weeks I was falling asleep faster and waking up less.
Kevin C.

Rated 5 out of 5
Honestly, I never realized how much morning light could affect my sleep until I tried what this suggested. Waking up is easier now.
Shane G.

Rated 5 out of 5
Blue light, deeper sleep.
Heather Z.

Rated 5 out of 5
I honestly didn’t expect much since I’ve been skeptical about DNA health stuff. But this surprised me. The suggestions like light therapy and blue-blocking glasses actually made sense for my sleep issues. After trying a couple things, I’ve slept better than usual. It actually felt personal, not generic advice.
Jeff H.

Rated 5 out of 5
The advice about melatonin and light exposure was actually helpful for my sleep, way better than just reading random tips online.

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MTNR1A (Melatonin)

Product features

Understanding Your MTNR1A (Melatonin) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the MTNR1A (Melatonin) gene do?

Why is the MTNR1A (Melatonin) gene important?

What can I do based on my MTNR1A (Melatonin) results?

Can MTNR1A (melatonin receptor) variants affect blood sugar and diabetes risk?

What SNPs are included in MTNR1A genetic testing in this DNA report?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers