What does the AANAT (Circadian Rhythm) gene do?

The AANAT (Circadian Rhythm) gene provides instructions for making an enzyme called aralkylamine N-acetyltransferase. This enzyme performs a key step in the body’s melatonin production pathway. Because melatonin is a major hormone involved in setting your sleep-wake cycle, AANAT activity helps regulate when your body gets the biochemical signal that it’s time to feel sleepy and transition into nighttime physiology.

Why is the AANAT (Circadian Rhythm) gene important?

AANAT is important because it influences melatonin synthesis, which helps coordinate circadian rhythm—your internal 24-hour timing system. Research has linked a rare genetic variant (including the ‘A’ allele of rs28936679) with increased risk of delayed sleep phase disorder, where sleep and wake times shift later by two hours or more. This same variant has also been associated with abnormal biological rhythms in people with bipolar disorder, highlighting how circadian regulation can intersect with mood and daily functioning. Knowing your AANAT genetic variants can help you understand whether circadian timing may be a meaningful lever for your sleep and overall well-being.

What can I do based on my AANAT (Circadian Rhythm) results?

Based on your AANAT (Circadian Rhythm) results, you’ll receive 7 personalized recommendations designed to be actionable and aligned with your genotype. These include dietary strategies (such as timing and choices that support nighttime physiology), lifestyle guidance (especially light exposure, sleep scheduling, and evening routines), and supplement recommendations (when relevant, with a focus on timing and fit for your profile). The goal is to help you make targeted changes that better support your natural circadian rhythm rather than relying on generic sleep advice.

Can AANAT gene variants affect melatonin and delayed sleep phase disorder?

Yes. AANAT helps regulate melatonin synthesis, and melatonin is a core signal for circadian timing. In research, a rare variant in AANAT (including the ‘A’ allele of rs28936679) has been associated with increased risk of delayed sleep phase disorder, a pattern where a person’s sleep and wake times are significantly shifted later than conventional schedules. While genetics is only one part of the picture (light exposure, routines, and environment matter too), AANAT-related differences may help explain why some people naturally drift toward later bedtimes and struggle with earlier schedules.

What do I get from an AANAT (Circadian Rhythm) genetic test report for sleep?

You get a focused analysis of your AANAT genetic variants and a clear explanation of what they may imply for melatonin production and circadian rhythm tendencies. The report then turns that insight into 7 personalized recommendations across dietary, lifestyle, and supplement categories. Instead of one-size-fits-all sleep tips, the guidance is tailored to your genotype—helping you identify the most relevant actions to support sleep timing, evening wind-down, and next-day energy.

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AANAT (Circadian Rhythm)

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

AANAT (Circadian Rhythm)

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

The report provides up to 7 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Trusted by 200,000+ users & 2,000+ doctors

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Analyzes Key Genetic Variants

Up to 7 DNA-Based, Science-Backed Recommendations

AANAT (Circadian Rhythm)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your AANAT (Circadian Rhythm) Variants: A DNA Gene Report

Do you feel tired at night but suddenly wide awake when it’s finally time to sleep? Do you struggle to fall asleep until very late, then feel “off” the next morning no matter how long you stay in bed? Have you ever wondered if your natural sleep timing is partly written into your biology? The AANAT (Circadian Rhythm) gene helps regulate melatonin production—one of the key signals that tells your body when it’s time to wind down—so understanding your AANAT genetic variants can offer clearer, more personal insight into why your sleep schedule may feel out of sync.

Key Report Highlights

This DNA report analyzes genetic variants in the AANAT (Circadian Rhythm) gene and translates your results into 7 personalized recommendations tailored to your genotype. AANAT encodes an enzyme that helps drive melatonin synthesis, acting like a biological “switch” that supports your sleep-wake rhythm. Compelling fact: melatonin doesn’t just influence sleep timing—it also plays roles in antioxidant activity, mood regulation, immune function, and broader hormonal balance, meaning melatonin-related differences can ripple into how you feel and function day to day.

Personalized, Actionable Recommendations

Your recommendations are personalized to your AANAT (Circadian Rhythm) genotype, helping you prioritize the strategies most likely to support your natural circadian biology. You’ll receive a targeted mix of dietary, lifestyle, and supplement recommendations—designed to be practical and easy to implement. For example, your report may suggest specific light-exposure habits (like morning bright-light routines and evening light reduction) and nutrition timing guidance that supports nighttime melatonin signaling. Where appropriate, it may also include supplement considerations (such as melatonin-related timing guidance) aligned with your genetic profile.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The AANAT (Circadian Rhythm) gene provides instructions for making an enzyme called aralkylamine N-acetyltransferase. This enzyme performs a key step in the body’s melatonin production pathway. Because melatonin is a major hormone involved in setting your sleep-wake cycle, AANAT activity helps regulate when your body gets the biochemical signal that it’s time to feel sleepy and transition into nighttime physiology.
: AANAT is important because it influences melatonin synthesis, which helps coordinate circadian rhythm—your internal 24-hour timing system. Research has linked a rare genetic variant (including the ‘A’ allele of rs28936679) with increased risk of delayed sleep phase disorder, where sleep and wake times shift later by two hours or more. This same variant has also been associated with abnormal biological rhythms in people with bipolar disorder, highlighting how circadian regulation can intersect with mood and daily functioning. Knowing your AANAT genetic variants can help you understand whether circadian timing may be a meaningful lever for your sleep and overall well-being.
: Based on your AANAT (Circadian Rhythm) results, you’ll receive 7 personalized recommendations designed to be actionable and aligned with your genotype. These include dietary strategies (such as timing and choices that support nighttime physiology), lifestyle guidance (especially light exposure, sleep scheduling, and evening routines), and supplement recommendations (when relevant, with a focus on timing and fit for your profile). The goal is to help you make targeted changes that better support your natural circadian rhythm rather than relying on generic sleep advice.
: Yes. AANAT helps regulate melatonin synthesis, and melatonin is a core signal for circadian timing. In research, a rare variant in AANAT (including the ‘A’ allele of rs28936679) has been associated with increased risk of delayed sleep phase disorder, a pattern where a person’s sleep and wake times are significantly shifted later than conventional schedules. While genetics is only one part of the picture (light exposure, routines, and environment matter too), AANAT-related differences may help explain why some people naturally drift toward later bedtimes and struggle with earlier schedules.
: You get a focused analysis of your AANAT genetic variants and a clear explanation of what they may imply for melatonin production and circadian rhythm tendencies. The report then turns that insight into 7 personalized recommendations across dietary, lifestyle, and supplement categories. Instead of one-size-fits-all sleep tips, the guidance is tailored to your genotype—helping you identify the most relevant actions to support sleep timing, evening wind-down, and next-day energy.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

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Aiden E.

Rated 5 out of 5
As a night shift nurse transitioning back to days, I was constantly wired at bedtime and dragging in the morning. This AANAT circadian rhythm report gave me a simple plan: reduce artificial light at night, get outdoor light soon after waking, and keep my sleep window consistent. I used a low dose melatonin only on the first few nights of the switch, as suggested. The report also reminded me to support tryptophan intake, so I added turkey and pumpkin seeds at dinner. My sleep feels more predictable now, and my morning mood is better.
Ananya B.

Rated 5 out of 5
I have struggled with late nights for years, and my dad has always had insomnia, so I tried the AANAT (Circadian Rhythm) report. It connected my genetics to melatonin production in a way that actually made sense. I started doing 10 to 15 minutes of morning sunlight exposure, cut bright screens after 9 pm, and added more dietary tryptophan at dinner. I also kept a regular sleep schedule, even on weekends. Within two weeks my sleep latency dropped, and I woke up feeling more alert.
Malik W.

Rated 5 out of 5
AANAT insights, steadier bedtime.

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AANAT (Circadian Rhythm)

Product features

Understanding Your AANAT (Circadian Rhythm) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the AANAT (Circadian Rhythm) gene do?

Why is the AANAT (Circadian Rhythm) gene important?

What can I do based on my AANAT (Circadian Rhythm) results?

Can AANAT gene variants affect melatonin and delayed sleep phase disorder?

What do I get from an AANAT (Circadian Rhythm) genetic test report for sleep?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers