What does the TMPRSS6 (Iron) gene do?

TMPRSS6 encodes a liver enzyme (matriptase-2) that helps regulate the hormone hepcidin. Hepcidin controls how much dietary iron is absorbed into the bloodstream. By influencing hepcidin levels, TMPRSS6 helps your body keep iron from dropping too low while still maintaining safe control over iron absorption.

Why is the TMPRSS6 (Iron) gene important?

TMPRSS6 is important because genetic differences in this gene have been associated with differences in blood iron levels and the likelihood of iron deficiency in research studies. For example, certain alleles in TMPRSS6 variants (including rs4820268 and rs855791) have been linked to relatively lower iron levels in many populations, while another variant (rs228916) includes an allele associated with slightly higher iron. Since iron balance affects energy, oxygen transport, and overall health—and because too little or too much iron can be problematic—TMPRSS6 can be a meaningful piece of your nutrition and wellness puzzle.

What can I do based on my TMPRSS6 (Iron) results?

Based on your TMPRSS6 (Iron) results, you’ll receive 3 personalized recommendations that translate your genotype into actionable guidance. These include dietary recommendations (how to structure iron intake and absorption-supporting food choices) and supplement recommendations (whether iron supplementation may be worth discussing, plus practical considerations like timing and monitoring). Your report helps you focus on strategies that fit your genetic tendency rather than relying on one-size-fits-all advice.

Can TMPRSS6 gene variants increase the risk of iron deficiency?

Yes. Multiple studies have associated specific TMPRSS6 variants with differences in blood iron markers and iron deficiency risk. In particular, the less common ‘G’ allele at rs4820268 has been associated with lower blood iron levels and possible iron deficiency. The less common ‘A’ allele at rs855791 has also been linked to relatively lower iron levels in many studies (though the size and direction of the effect can vary by population). Your report evaluates these variants together to provide a more personalized interpretation and practical nutrition-focused recommendations.

What do TMPRSS6 (Iron) genetic test results tell me about iron absorption and supplements?

TMPRSS6 results can indicate whether your genetics may be more consistent with lower iron levels (potentially reflecting stronger hepcidin signaling and reduced iron absorption) or slightly higher iron levels for certain variants. The report doesn’t diagnose iron deficiency or iron overload on its own, but it can help explain why you may respond differently to diet or supplementation. Your personalized recommendations may include genotype-informed dietary strategies to improve iron bioavailability and supplement guidance—such as when to consider discussing iron with a clinician and why monitoring labs (like ferritin and transferrin saturation) matters, especially because excess iron can be harmful.

Save $30

TMPRSS6 (Iron)

Rated 4.67 out of 5 based on 12 customer ratings

4.7 (13 reviews)

TMPRSS6 (Iron)

Rated 4.67 out of 5 based on 12 customer ratings

4.7 (13 reviews)

The report provides up to 3 personalized recommendations based on 3 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes 3 Genetic Variants

Up to 3 DNA-Based, Science-Backed Recommendations

TMPRSS6 (Iron)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your TMPRSS6 (Iron) Variants: A DNA Gene Report

Do you struggle with low iron, fatigue, or “borderline” lab results that don’t seem to improve no matter what you eat? Have you ever wondered why some people absorb iron easily while others become deficient? Your TMPRSS6 (Iron) gene helps regulate how your body controls iron absorption through a key hormone called hepcidin—so understanding your TMPRSS6 variants can clarify whether your genetics may be nudging your iron levels lower (or higher) and what to do about it.

Key Report Highlights

This TMPRSS6 (Iron) Gene Report analyzes 3 clinically studied genetic variants—rs4820268, rs855791, and rs228916—to help explain your tendency toward lower or higher blood iron levels. You’ll receive 3 personalized recommendations tailored to your genotype, including dietary and supplement guidance. TMPRSS6 plays a central biological role in regulating hepcidin, the hormone that acts like a “gatekeeper” for iron absorption; when hepcidin is higher, less iron is absorbed from food, and when it’s lower, absorption can increase—making TMPRSS6 a powerful genetic influence on iron balance.

Personalized, Actionable Recommendations

Your recommendations are generated from your specific TMPRSS6 (Iron) genotype, translating your SNP results into practical, personalized next steps. Depending on your variant pattern and what it suggests about iron status risk, your report may include dietary recommendations (e.g., optimizing iron-rich foods and improving absorption with vitamin C while timing inhibitors like tea/coffee) and supplement recommendations (e.g., guidance on whether iron supplementation may be appropriate to discuss with a clinician, plus dosing considerations and monitoring reminders). The goal is targeted, DNA-informed guidance rather than generic “take iron” advice.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: TMPRSS6 encodes a liver enzyme (matriptase-2) that helps regulate the hormone hepcidin. Hepcidin controls how much dietary iron is absorbed into the bloodstream. By influencing hepcidin levels, TMPRSS6 helps your body keep iron from dropping too low while still maintaining safe control over iron absorption.
: TMPRSS6 is important because genetic differences in this gene have been associated with differences in blood iron levels and the likelihood of iron deficiency in research studies. For example, certain alleles in TMPRSS6 variants (including rs4820268 and rs855791) have been linked to relatively lower iron levels in many populations, while another variant (rs228916) includes an allele associated with slightly higher iron. Since iron balance affects energy, oxygen transport, and overall health—and because too little or too much iron can be problematic—TMPRSS6 can be a meaningful piece of your nutrition and wellness puzzle.
: Based on your TMPRSS6 (Iron) results, you’ll receive 3 personalized recommendations that translate your genotype into actionable guidance. These include dietary recommendations (how to structure iron intake and absorption-supporting food choices) and supplement recommendations (whether iron supplementation may be worth discussing, plus practical considerations like timing and monitoring). Your report helps you focus on strategies that fit your genetic tendency rather than relying on one-size-fits-all advice.
: Yes. Multiple studies have associated specific TMPRSS6 variants with differences in blood iron markers and iron deficiency risk. In particular, the less common ‘G’ allele at rs4820268 has been associated with lower blood iron levels and possible iron deficiency. The less common ‘A’ allele at rs855791 has also been linked to relatively lower iron levels in many studies (though the size and direction of the effect can vary by population). Your report evaluates these variants together to provide a more personalized interpretation and practical nutrition-focused recommendations.
: TMPRSS6 results can indicate whether your genetics may be more consistent with lower iron levels (potentially reflecting stronger hepcidin signaling and reduced iron absorption) or slightly higher iron levels for certain variants. The report doesn’t diagnose iron deficiency or iron overload on its own, but it can help explain why you may respond differently to diet or supplementation. Your personalized recommendations may include genotype-informed dietary strategies to improve iron bioavailability and supplement guidance—such as when to consider discussing iron with a clinician and why monitoring labs (like ferritin and transferrin saturation) matters, especially because excess iron can be harmful.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.67 out of 5 based on 12 customer ratings

4.7 (13 reviews)

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Emily K.

Rated 3 out of 5
This TMPRSS6 (Iron) report clarified why I should not casually take iron. The iron and calcium timing tip was useful, but the curcumin BCM95 suggestion felt underexplained for my situation. I also wanted clearer guidance for vegetarians.
Amber H.

Rated 4 out of 5
The TMPRSS6 (Iron) report helped me understand why my ferritin has been low on and off, even when I was eating “iron rich” foods. I liked that it didn’t just push more supplements, it clearly warned about avoiding iron supplements unless deficient and explained how that can backfire. The section on balancing iron and calcium intake was practical, I moved my calcium away from iron heavy meals and my next labs nudged up. I’m giving 4 stars because I wanted a bit more detail on ideal retest timing and how to interpret borderline transferrin saturation.
Paul T.

Rated 5 out of 5
I really liked how the analysis highlighted my iron metabolism tendencies, and the focus on avoiding supplements unless deficient made sense. My only issue is that some of the explanations were a bit too technical for me, so I had to look things up. Would love a glossary or a summary chart.
James W.

Rated 5 out of 5
Ferritin finally makes sense.
Tariq E.

Rated 5 out of 5
Stopped iron pills, finally.

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TMPRSS6 (Iron)

Product features

Understanding Your TMPRSS6 (Iron) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the TMPRSS6 (Iron) gene do?

Why is the TMPRSS6 (Iron) gene important?

What can I do based on my TMPRSS6 (Iron) results?

Can TMPRSS6 gene variants increase the risk of iron deficiency?

What do TMPRSS6 (Iron) genetic test results tell me about iron absorption and supplements?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers