What does the TCN2 (Vitamin B12) gene do?

The TCN2 gene provides instructions for making transcobalamin, a protein that binds vitamin B12 in the bloodstream and helps deliver it into your cells. Once inside cells, vitamin B12 acts as a cofactor for key reactions involved in methylation, including the conversion of homocysteine to methionine—processes important for DNA synthesis, red blood cell formation, and nervous system function.

Why is the TCN2 (Vitamin B12) gene important?

TCN2 is important because it affects how efficiently vitamin B12 is transported and made available to tissues. Research on the well-studied rs1801198 (C776G) variant suggests that the “GG” genotype is associated with lower levels of active B12 (holotranscobalamin) and, in European descendants, higher homocysteine. While this variant has not been consistently linked to major diseases in large reviews, it can influence nutritional biomarkers that matter for long-term metabolic and cardiovascular resilience.

What can I do based on my TCN2 (Vitamin B12) results?

Based on your TCN2 (Vitamin B12) results, you’ll receive 3 personalized recommendations focused on actionable dietary and supplement guidance. This can include food-first strategies to increase B12 intake in a way that fits your eating pattern, plus targeted supplement considerations to support active B12 status and help manage homocysteine-related methylation demands. Your plan is tailored to your genotype so you can prioritize the steps most relevant to your biology.

Can TCN2 (Vitamin B12) genetic variants affect homocysteine levels?

Yes. TCN2 genetic variants can influence how much vitamin B12 is delivered into cells, which matters because B12 is required for the methylation pathway that converts homocysteine to methionine. A large review of multiple studies reported that the rs1801198 (C776G) “GG” genotype is associated with lower active B12 (holotranscobalamin) and higher homocysteine in European descendants. Your DNA report helps interpret this genetic signal and pairs it with personalized nutrition and supplement recommendations aimed at supporting healthy B12 utilization and methylation.

What is included in a TCN2 (Vitamin B12) genetic testing report?

A TCN2 (Vitamin B12) genetic testing report analyzes genetic variants in the TCN2 gene and explains what your genotype may suggest about B12 transport and active B12 status. You’ll get clear, consumer-friendly education on the biology of transcobalamin, how B12 supports methylation and homocysteine metabolism, and what the research shows for key variants such as rs1801198 (C776G). The report then translates your results into 3 personalized recommendations, including dietary and supplement guidance, so you can take practical steps aligned with your genetics.

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TCN2 (Vitamin B12)

Rated 4.79 out of 5 based on 14 customer ratings

4.8 (15 reviews)

TCN2 (Vitamin B12)

Rated 4.79 out of 5 based on 14 customer ratings

4.8 (15 reviews)

The report provides up to 3 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Trusted by 200,000+ users & 2,000+ doctors

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Analyzes Key Genetic Variants

Up to 3 DNA-Based, Science-Backed Recommendations

TCN2 (Vitamin B12)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your TCN2 (Vitamin B12) Variants: A DNA Gene Report

Do you eat B12-rich foods but still wonder why your energy, focus, or lab numbers don’t feel “optimal”? Have you ever been told your homocysteine is high—or that your B12 looks normal, yet symptoms persist? Your TCN2 (Vitamin B12) gene helps deliver vitamin B12 into your cells, and understanding your TCN2 genetic variants can reveal whether you may need a more personalized approach to getting enough active B12 where it matters most.

Key Report Highlights

This DNA report analyzes genetic variants in the TCN2 (Vitamin B12) gene and translates your results into 3 personalized recommendations tailored to your genotype. TCN2 encodes transcobalamin, the carrier protein that binds vitamin B12 and transports it into cells, where B12 supports essential methylation reactions—like converting homocysteine to methionine. A compelling takeaway: certain TCN2 variants are linked to lower levels of active B12 (holotranscobalamin) and, in some populations, higher homocysteine—two markers closely tied to cardiovascular and cognitive health foundations.

Personalized, Actionable Recommendations

Your recommendations are personalized to your TCN2 (Vitamin B12) genotype, helping you focus on the dietary and supplement strategies most likely to support healthy B12 status and methylation. Depending on your results, you may see guidance such as prioritizing B12-rich foods (e.g., fish, eggs, dairy, or fortified options) and pairing them with supportive nutrients, or targeted supplement suggestions (for example, choosing an appropriate form and dose of vitamin B12 and timing it consistently). The goal is practical, DNA-informed steps that align with how your body may transport and utilize B12.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The TCN2 gene provides instructions for making transcobalamin, a protein that binds vitamin B12 in the bloodstream and helps deliver it into your cells. Once inside cells, vitamin B12 acts as a cofactor for key reactions involved in methylation, including the conversion of homocysteine to methionine—processes important for DNA synthesis, red blood cell formation, and nervous system function.
: TCN2 is important because it affects how efficiently vitamin B12 is transported and made available to tissues. Research on the well-studied rs1801198 (C776G) variant suggests that the “GG” genotype is associated with lower levels of active B12 (holotranscobalamin) and, in European descendants, higher homocysteine. While this variant has not been consistently linked to major diseases in large reviews, it can influence nutritional biomarkers that matter for long-term metabolic and cardiovascular resilience.
: Based on your TCN2 (Vitamin B12) results, you’ll receive 3 personalized recommendations focused on actionable dietary and supplement guidance. This can include food-first strategies to increase B12 intake in a way that fits your eating pattern, plus targeted supplement considerations to support active B12 status and help manage homocysteine-related methylation demands. Your plan is tailored to your genotype so you can prioritize the steps most relevant to your biology.
: Yes. TCN2 genetic variants can influence how much vitamin B12 is delivered into cells, which matters because B12 is required for the methylation pathway that converts homocysteine to methionine. A large review of multiple studies reported that the rs1801198 (C776G) “GG” genotype is associated with lower active B12 (holotranscobalamin) and higher homocysteine in European descendants. Your DNA report helps interpret this genetic signal and pairs it with personalized nutrition and supplement recommendations aimed at supporting healthy B12 utilization and methylation.
: A TCN2 (Vitamin B12) genetic testing report analyzes genetic variants in the TCN2 gene and explains what your genotype may suggest about B12 transport and active B12 status. You’ll get clear, consumer-friendly education on the biology of transcobalamin, how B12 supports methylation and homocysteine metabolism, and what the research shows for key variants such as rs1801198 (C776G). The report then translates your results into 3 personalized recommendations, including dietary and supplement guidance, so you can take practical steps aligned with your genetics.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.79 out of 5 based on 14 customer ratings

4.8 (15 reviews)

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Stephanie G.

Rated 5 out of 5
B12 transport, decoded fast.
Simone G.

Rated 5 out of 5
The TCN2 (Vitamin B12) report connected a lot of dots for me. I’ve had on and off tingling in my hands and a weird “foggy” feeling, but my basic labs were always borderline and I kept shrugging it off. Seeing how TCN2 can affect B12 transport made me take it seriously. I started a consistent vitamin B12 supplement, prioritized dietary vitamin B12 at breakfast, and followed the “limit alcohol to up to 1 drink a day” suggestion. Within a few weeks my energy felt steadier, and I stopped getting that afternoon crash.
Derek E.

Rated 5 out of 5
Achei muito interessante entender como meus genes influenciam a absorção de vitamina B12. As recomendações foram práticas e já estou ajustando minha alimentação.
Megan N.

Rated 5 out of 5
I’ve purchased several different health analyses from this platform and the tcn2 vitamin b12 one is definitely one of my favorites. It gave clear steps and actually helped me see what changes made sense for me personally. Super useful compared to some others I’ve tried before.
Marcus D.

Rated 5 out of 5
Methyl trap, finally explained.

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TCN2 (Vitamin B12)

Product features

Understanding Your TCN2 (Vitamin B12) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the TCN2 (Vitamin B12) gene do?

Why is the TCN2 (Vitamin B12) gene important?

What can I do based on my TCN2 (Vitamin B12) results?

Can TCN2 (Vitamin B12) genetic variants affect homocysteine levels?

What is included in a TCN2 (Vitamin B12) genetic testing report?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers