What does the SHMT1 (Folate/ Methylation) gene do?

The SHMT1 (Folate/ Methylation) gene provides instructions for making an enzyme called serine hydroxymethyltransferase (SHMT). This enzyme helps move “one‑carbon” units (methyl groups) between folate forms, supporting two critical needs: making DNA building blocks (nucleotides) and supporting methylation processes involved in SAM-e production and homocysteine metabolism. In simple terms, SHMT1 helps your body decide how to use folate—toward building and repair, or toward methylation-related chemistry.

Why is the SHMT1 (Folate/ Methylation) gene important?

SHMT1 is important because genetic variants can shift how efficiently folate is converted into active intermediates used in methylation and cellular function. For example, the commonly studied rs1979277 variant (often discussed in research) has been associated with reduced production of 5,10‑MTHF in some contexts, which may lower active folate availability and potentially affect methylation balance. Research has also linked certain SHMT1 variants with health risks such as liver disease and developmental outcomes, and some findings suggest SHMT1 can interact with other folate-pathway genes (like MTHFR), potentially amplifying effects in certain individuals.

What can I do based on my SHMT1 (Folate/ Methylation) results?

Based on your SHMT1 (Folate/ Methylation) results, you’ll receive 11 personalized recommendations focused on actionable nutrition support. These include dietary guidance (what to emphasize in your eating pattern to support folate needs) and supplement considerations (which nutrients and forms may be most relevant for your genotype). Your report is designed to help you prioritize practical next steps—such as food-first folate strategies, targeted B‑vitamin support, and methylation-informed habits—based on what your DNA suggests about folate handling.

How do SHMT1 (Folate/ Methylation) variants affect folate metabolism and methylation?

SHMT1 variants may influence the efficiency of the SHMT enzyme in transferring one‑carbon units between folate forms, which can affect the balance between the folate cycle (supporting nucleotide production) and the methylation cycle (supporting SAM-e production and homocysteine processing). If certain variants reduce the availability of key active folate intermediates (such as 5,10‑MTHF in some research contexts), methylation capacity may be less supported—especially when dietary folate intake is low or when other folate-pathway variants are also present. A DNA-based SHMT1 report helps translate these genetic tendencies into personalized nutrition and supplement strategies.

What is included in SHMT1 (Folate/ Methylation) genetic testing for nutrition?

A SHMT1 (Folate/ Methylation) genetic test evaluates genetic variants in the SHMT1 gene that research has associated with differences in folate utilization and methylation-related pathways. Your report interprets your genotype in plain language and provides 11 personalized recommendations, including dietary and supplement guidance, to help you support folate metabolism in a targeted way. It can also highlight when SHMT1 findings may be especially relevant alongside other folate-pathway genes, helping you have a more informed conversation with a clinician or nutrition professional.

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SHMT1 (Folate/ Methylation)

Rated 4.71 out of 5 based on 14 customer ratings

4.7 (15 reviews)

SHMT1 (Folate/ Methylation)

Rated 4.71 out of 5 based on 14 customer ratings

4.7 (15 reviews)

The report provides up to 11 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Trusted by 200,000+ users & 2,000+ doctors

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Analyzes Key Genetic Variants

Up to 11 DNA-Based, Science-Backed Recommendations

SHMT1 (Folate/ Methylation)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your SHMT1 (Folate/ Methylation) Variants: A DNA Gene Report

Do you ever wonder why a “healthy diet” doesn’t always translate into steady energy, balanced labs, or optimal wellness? Have you been told to “take folate” but aren’t sure which form—or whether it’s actually supporting your methylation needs? What if your SHMT1 (Folate/ Methylation) gene is influencing how efficiently your body allocates folate toward methylation versus DNA building blocks? Understanding your SHMT1 genetic variants can help explain how your body processes folate and where targeted nutrition support may make the biggest difference.

Key Report Highlights

This SHMT1 (Folate/ Methylation) Gene Report analyzes key genetic variants that may influence how efficiently you convert and shuttle folate-derived one‑carbon units between the folate cycle (nucleotide production) and the methylation cycle (SAM-e production and homocysteine handling). You’ll receive 11 personalized recommendations tailored to your genotype, translating your DNA into clear next steps. A compelling takeaway: SHMT1 helps determine how much folate is available in the active forms your body uses for methylation—an essential process involved in cardiovascular health, detox pathways, and healthy cell division.

Personalized, Actionable Recommendations

Your results unlock personalized dietary and supplement recommendations based on your SHMT1 (Folate/ Methylation) genotype—so you’re not guessing what “folate support” should look like for you. Depending on your genetic variants, your plan may include guidance to prioritize folate-rich foods (such as leafy greens and legumes) in a way that supports methylation demands, or supplement suggestions focused on specific folate forms and supportive B‑vitamins commonly used in methylation-focused protocols. The goal is practical, DNA-informed guidance you can discuss with your healthcare professional and apply to your daily routine.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The SHMT1 (Folate/ Methylation) gene provides instructions for making an enzyme called serine hydroxymethyltransferase (SHMT). This enzyme helps move “one‑carbon” units (methyl groups) between folate forms, supporting two critical needs: making DNA building blocks (nucleotides) and supporting methylation processes involved in SAM-e production and homocysteine metabolism. In simple terms, SHMT1 helps your body decide how to use folate—toward building and repair, or toward methylation-related chemistry.
: SHMT1 is important because genetic variants can shift how efficiently folate is converted into active intermediates used in methylation and cellular function. For example, the commonly studied rs1979277 variant (often discussed in research) has been associated with reduced production of 5,10‑MTHF in some contexts, which may lower active folate availability and potentially affect methylation balance. Research has also linked certain SHMT1 variants with health risks such as liver disease and developmental outcomes, and some findings suggest SHMT1 can interact with other folate-pathway genes (like MTHFR), potentially amplifying effects in certain individuals.
: Based on your SHMT1 (Folate/ Methylation) results, you’ll receive 11 personalized recommendations focused on actionable nutrition support. These include dietary guidance (what to emphasize in your eating pattern to support folate needs) and supplement considerations (which nutrients and forms may be most relevant for your genotype). Your report is designed to help you prioritize practical next steps—such as food-first folate strategies, targeted B‑vitamin support, and methylation-informed habits—based on what your DNA suggests about folate handling.
: SHMT1 variants may influence the efficiency of the SHMT enzyme in transferring one‑carbon units between folate forms, which can affect the balance between the folate cycle (supporting nucleotide production) and the methylation cycle (supporting SAM-e production and homocysteine processing). If certain variants reduce the availability of key active folate intermediates (such as 5,10‑MTHF in some research contexts), methylation capacity may be less supported—especially when dietary folate intake is low or when other folate-pathway variants are also present. A DNA-based SHMT1 report helps translate these genetic tendencies into personalized nutrition and supplement strategies.
: A SHMT1 (Folate/ Methylation) genetic test evaluates genetic variants in the SHMT1 gene that research has associated with differences in folate utilization and methylation-related pathways. Your report interprets your genotype in plain language and provides 11 personalized recommendations, including dietary and supplement guidance, to help you support folate metabolism in a targeted way. It can also highlight when SHMT1 findings may be especially relevant alongside other folate-pathway genes, helping you have a more informed conversation with a clinician or nutrition professional.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.71 out of 5 based on 14 customer ratings

4.7 (15 reviews)

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Tammy W.

Rated 5 out of 5
Super easy to understand and now I actually know which vitamins I need!
James L.

Rated 5 out of 5
I’m not the review-leaving type, but I had to comment on this. The breakdown was way more useful than I expected and actually explained a few things about my energy levels and vitamins. Didn’t expect to change my supplement routine, but here I am.
Quinn F.

Rated 4 out of 5
Helpful, but dense pathways.
Keisha R.

Rated 5 out of 5
The SHMT1 (Folate, Methylation) report finally explained why standard folate advice never felt consistent for me. It connected my variant to one carbon metabolism in plain language and gave a clear plan. I added riboflavin (B2) and a modest B6 supplement, then focused on choline with breakfast. Within two weeks my afternoon brain fog eased and my workouts stopped feeling like I was running on fumes. I also appreciated the notes on glycine and L-serine as optional supports instead of pushing a huge stack.
Eric B.

Rated 5 out of 5
B2 fixed my methylation slump.

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SHMT1 (Folate/ Methylation)

Product features

Understanding Your SHMT1 (Folate/ Methylation) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the SHMT1 (Folate/ Methylation) gene do?

Why is the SHMT1 (Folate/ Methylation) gene important?

What can I do based on my SHMT1 (Folate/ Methylation) results?

How do SHMT1 (Folate/ Methylation) variants affect folate metabolism and methylation?

What is included in SHMT1 (Folate/ Methylation) genetic testing for nutrition?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers