What does the MTHFD1 (Folate/ Methylation) gene do?

MTHFD1 (Methylenetetrahydrofolate dehydrogenase 1) helps your body process folate (vitamin B9) into active folate forms used in one-carbon metabolism. This pathway supports two major needs: making DNA building blocks (nucleotides) and supplying methyl groups that help convert homocysteine into methionine. In simple terms, MTHFD1 helps your body “use” folate efficiently for cellular repair, growth, and methylation-related processes.

Why is the MTHFD1 (Folate/ Methylation) gene important?

MTHFD1 is important because genetic variants can reduce how stable or efficient the MTHFD1 enzyme is, which may lower the availability of methylated folate (methyl-THF). When methyl-THF is limited—especially during periods of low folate intake—the body may rely more heavily on choline as an alternate source of methyl groups. Research has linked a common MTHFD1 variant (rs2236225 A allele) with a higher risk of developing signs of choline deficiency on a low-choline diet, and with larger homocysteine increases during low-folate intake in some groups. This is why MTHFD1 can matter for nutrition strategy and methylation support.

What can I do based on my MTHFD1 (Folate/ Methylation) results?

Based on your MTHFD1 (Folate/ Methylation) results, you’ll receive 8 personalized recommendations focused on dietary and supplement actions. Your plan may include guidance on optimizing folate intake and form (food sources and/or supplement considerations), supporting choline status through diet, and practical steps that align with methylation and one-carbon metabolism needs. The goal is to turn your genetic findings into clear, actionable next steps you can discuss with your healthcare professional.

How does the MTHFD1 (Folate/ Methylation) gene relate to choline deficiency and fatty liver risk?

MTHFD1 helps generate methylated folate (methyl-THF), which supplies methyl groups used to convert homocysteine into methionine. If MTHFD1 activity is reduced due to certain genetic variants, the body may compensate by using more choline-derived methyl groups to keep methylation reactions running. In a controlled diet study, participants with the rs2236225 “A” allele were much more likely to develop signs of choline deficiency (including fatty liver) when placed on a low-choline diet. This doesn’t mean a variant “causes” fatty liver on its own, but it suggests that some people may be more sensitive to low choline intake and may benefit from a more intentional choline and folate strategy.

What can MTHFD1 genetic testing tell me about folate (B9) and methylation support?

MTHFD1 genetic testing can help explain why folate needs and responses can vary between individuals. Because MTHFD1 participates in activating and cycling folate within one-carbon metabolism, certain genetic variants may influence how efficiently methylated folate is produced—especially during periods of low dietary folate. Your MTHFD1 gene report connects your genetic variants to personalized dietary and supplement recommendations, which may include guidance on folate-rich foods, considerations around folate forms (such as L-methylfolate versus folic acid), and when supporting choline intake may be relevant for methylation balance and homocysteine support.

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MTHFD1 (Folate/ Methylation)

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

MTHFD1 (Folate/ Methylation)

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

The report provides up to 8 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes Key Genetic Variants

Up to 8 DNA-Based, Science-Backed Recommendations

MTHFD1 (Folate/ Methylation)

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your MTHFD1 (Folate/ Methylation) Variants: A DNA Gene Report

Do you take folate or a B-complex and still wonder why your energy, labs, or “detox” support don’t feel consistent? Have you ever been told to “support methylation,” but no one explained what that means for your body? Your MTHFD1 (Folate/ Methylation) gene helps convert folate into forms your cells use for methylation and DNA building blocks—so understanding your MTHFD1 genetic variants can clarify why your nutrient needs (especially folate and choline) may be more personal than you think.

Key Report Highlights

This DNA report analyzes key genetic variants in the MTHFD1 (Folate/ Methylation) gene and translates them into 8 personalized recommendations. MTHFD1 supports one-carbon metabolism—an essential pathway that helps your body create methyl groups used for healthy homocysteine balance and cellular repair. A compelling insight from research: certain MTHFD1 variants are associated with a markedly higher likelihood of developing signs of choline deficiency during a low-choline diet, highlighting how genetics can influence your day-to-day nutrient requirements.

Personalized, Actionable Recommendations

Your recommendations are tailored to your MTHFD1 (Folate/ Methylation) genotype, with clear dietary and supplement guidance designed to fit real life. Depending on your results, your report may suggest practical food-first strategies to support folate and choline status (for example, emphasizing choline-rich foods like eggs or targeted folate sources), and supplement considerations (such as discussing folate forms like L-methylfolate versus folic acid, or when choline support may be worth considering). Every recommendation is personalized to help you make confident, DNA-informed choices.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: MTHFD1 (Methylenetetrahydrofolate dehydrogenase 1) helps your body process folate (vitamin B9) into active folate forms used in one-carbon metabolism. This pathway supports two major needs: making DNA building blocks (nucleotides) and supplying methyl groups that help convert homocysteine into methionine. In simple terms, MTHFD1 helps your body “use” folate efficiently for cellular repair, growth, and methylation-related processes.
: MTHFD1 is important because genetic variants can reduce how stable or efficient the MTHFD1 enzyme is, which may lower the availability of methylated folate (methyl-THF). When methyl-THF is limited—especially during periods of low folate intake—the body may rely more heavily on choline as an alternate source of methyl groups. Research has linked a common MTHFD1 variant (rs2236225 A allele) with a higher risk of developing signs of choline deficiency on a low-choline diet, and with larger homocysteine increases during low-folate intake in some groups. This is why MTHFD1 can matter for nutrition strategy and methylation support.
: Based on your MTHFD1 (Folate/ Methylation) results, you’ll receive 8 personalized recommendations focused on dietary and supplement actions. Your plan may include guidance on optimizing folate intake and form (food sources and/or supplement considerations), supporting choline status through diet, and practical steps that align with methylation and one-carbon metabolism needs. The goal is to turn your genetic findings into clear, actionable next steps you can discuss with your healthcare professional.
: MTHFD1 helps generate methylated folate (methyl-THF), which supplies methyl groups used to convert homocysteine into methionine. If MTHFD1 activity is reduced due to certain genetic variants, the body may compensate by using more choline-derived methyl groups to keep methylation reactions running. In a controlled diet study, participants with the rs2236225 “A” allele were much more likely to develop signs of choline deficiency (including fatty liver) when placed on a low-choline diet. This doesn’t mean a variant “causes” fatty liver on its own, but it suggests that some people may be more sensitive to low choline intake and may benefit from a more intentional choline and folate strategy.
: MTHFD1 genetic testing can help explain why folate needs and responses can vary between individuals. Because MTHFD1 participates in activating and cycling folate within one-carbon metabolism, certain genetic variants may influence how efficiently methylated folate is produced—especially during periods of low dietary folate. Your MTHFD1 gene report connects your genetic variants to personalized dietary and supplement recommendations, which may include guidance on folate-rich foods, considerations around folate forms (such as L-methylfolate versus folic acid), and when supporting choline intake may be relevant for methylation balance and homocysteine support.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

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Terrence D.

Rated 5 out of 5
I’m 29, vegetarian, and I assumed I had folate covered because I eat lots of greens. The MTHFD1 (Folate/ Methylation) report showed why methylation support can still lag, and it gave me a simple plan. I added more dietary choline with eggs-free options, plus a choline supplement on busy weeks, and paired it with pyridoxine (vitamin B6) as suggested. I also tightened my alcohol to one drink max. Within a month my afternoon crash was less intense and my workouts felt less “wired then wiped.”
Carmen V.

Rated 5 out of 5
Tengo 38 y siempre me salían folatos “normales”, pero seguía con cansancio y niebla mental. El informe de MTHFD1 (Folate/ Methylation) me explicó por qué, y me dio pasos claros: priorizar folato dietario, sumar colina en la comida y considerar colina en suplemento. También me recomendó piridoxina (vitamina B6), y me ayudó a ajustar la dosis con mi médico. Lo que más me sirvió fue el recordatorio de limitar el alcohol a máximo una bebida al día, noté mejor sueño y energía más estable en tres semanas.
Noah G.

Rated 5 out of 5
Eggs unlocked my methylation.
Valerie B.

Rated 4 out of 5
Skeptical at first about DNA testing for nutrition, I didn’t think I’d learn anything new. But I was pretty surprised to see precise recommendations for folate and choline that fit with some health issues I’d noticed. My only gripe is the food ideas could be more diverse but otherwise, it’s legit helpful.
Ben C.

Rated 5 out of 5
I’ve looked up a ton of info about folate and methylation online but this actually pulled everything together and made clear connections to my DNA. Other sources are usually too general or leave me guessing. This explained why certain vitamins might matter more for me, which felt unique compared to just reading blogs.

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MTHFD1 (Folate/ Methylation)

Product features

Understanding Your MTHFD1 (Folate/ Methylation) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the MTHFD1 (Folate/ Methylation) gene do?

Why is the MTHFD1 (Folate/ Methylation) gene important?

What can I do based on my MTHFD1 (Folate/ Methylation) results?

How does the MTHFD1 (Folate/ Methylation) gene relate to choline deficiency and fatty liver risk?

What can MTHFD1 genetic testing tell me about folate (B9) and methylation support?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers