What does the MAT1A (Methylation) gene do?

MAT1A provides instructions for making methionine adenosyltransferase (MAT), an enzyme that converts methionine into S-adenosylmethionine (SAM-e). SAM-e is a primary “methyl donor” your body uses for methylation—an essential process involved in DNA regulation, neurotransmitter and hormone metabolism, and nutrient processing. Because MAT1A sits near the start of SAM-e production, it can influence how smoothly the methylation cycle runs.

Why is the MAT1A (Methylation) gene important?

MAT1A is important because genetic variants can affect MAT enzyme activity and, as a result, SAM-e availability and methylation efficiency. In studies, certain MAT1A variants have been associated with higher homocysteine levels under specific conditions (such as low folate status, and in some cases higher fat intake), and one variant has been linked to increased odds of stroke in that context. Other MAT1A variants have been associated with a more favorable profile—such as lower likelihood of high blood pressure and stroke—and less DNA damage, particularly when vitamin B6 status is higher. This is why a DNA-based approach paired with nutrition insights can be especially valuable.

What can I do based on my MAT1A (Methylation) results?

Based on your MAT1A (Methylation) results, you’ll receive 4 personalized recommendations focused on actionable steps you can take now. These include dietary and supplement recommendations tailored to your genotype, with guidance that may address methylation support, homocysteine-related nutrition strategies, and key cofactors such as folate and vitamin B6. Your report helps you prioritize the most relevant changes for your biology—rather than using a one-size-fits-all methylation plan.

How is MAT1A (Methylation) linked to homocysteine and stroke risk?

MAT1A influences production of SAM-e, which is central to methylation pathways that intersect with homocysteine metabolism. Research has reported that a specific MAT1A variant (rs3851059) was associated with higher homocysteine levels when folate status was low, and in the same study this pattern corresponded to substantially higher odds of stroke. Another study suggested the relationship between this variant and elevated homocysteine may be more apparent in people with higher fat intake. Importantly, these findings highlight that risk is not determined by genes alone—nutrient status and dietary patterns can modify how a variant expresses—making personalized, nutrition-based recommendations especially useful.

What do MAT1A (Methylation) genetic testing results tell me about nutrition and heart health?

MAT1A genetic testing can indicate whether you may have variants associated with differences in methylation efficiency and related nutrient needs. Because studies link certain MAT1A variants with homocysteine levels and cardiovascular-related outcomes (including blood pressure and stroke risk in specific contexts), your results can help you focus on the nutrition levers most likely to matter for you. This report translates your MAT1A genotype into personalized dietary and supplement recommendations—such as optimizing folate and vitamin B6 status—so you can support methylation and heart & blood vessel health with a plan built around your DNA.

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MAT1A (Methylation)

Rated 4.89 out of 5 based on 9 customer ratings

4.9 (10 reviews)

MAT1A (Methylation)

Rated 4.89 out of 5 based on 9 customer ratings

4.9 (10 reviews)

The report provides up to 4 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes Key Genetic Variants

Up to 4 DNA-Based, Science-Backed Recommendations

MAT1A (Methylation)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your MAT1A (Methylation) Variants: A DNA Gene Report

Do you ever wonder why your energy, mood, or cardiovascular markers don’t respond the way you expect to diet and supplements? Have you been told your homocysteine is “a bit high,” or that you should pay closer attention to methylation and B vitamins? Your MAT1A (Methylation) gene helps your body produce SAM-e—one of the most important molecules for methylation—so understanding your MAT1A genetic variants can reveal why certain nutrition strategies may work better for you than for someone else.

Key Report Highlights

This MAT1A (Methylation) Gene Report analyzes key genetic variants that can influence how efficiently you produce SAM-e, a central driver of methylation. You’ll receive 4 personalized recommendations tailored to your DNA, spanning targeted dietary and supplement guidance. A compelling takeaway: research links certain MAT1A variants with differences in homocysteine levels—an important cardiovascular-related marker—and, in some contexts, stroke risk, especially when folate or vitamin B6 status (and even fat intake) isn’t optimal.

Personalized, Actionable Recommendations

Your results translate into clear, personalized actions based on your MAT1A (Methylation) genotype—so you’re not guessing which “methylation support” approach fits you. The report includes dietary and supplement recommendations designed around gene–nutrient interactions seen in research. For example, you may receive guidance to prioritize folate-rich foods (or specific forms of folate) to support healthy homocysteine levels, and targeted support for vitamin B6 status where it may be especially beneficial for DNA protection and cardiovascular-related outcomes. Recommendations are practical, personalized, and focused on nutrition and heart & blood vessel health.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: MAT1A provides instructions for making methionine adenosyltransferase (MAT), an enzyme that converts methionine into S-adenosylmethionine (SAM-e). SAM-e is a primary “methyl donor” your body uses for methylation—an essential process involved in DNA regulation, neurotransmitter and hormone metabolism, and nutrient processing. Because MAT1A sits near the start of SAM-e production, it can influence how smoothly the methylation cycle runs.
: MAT1A is important because genetic variants can affect MAT enzyme activity and, as a result, SAM-e availability and methylation efficiency. In studies, certain MAT1A variants have been associated with higher homocysteine levels under specific conditions (such as low folate status, and in some cases higher fat intake), and one variant has been linked to increased odds of stroke in that context. Other MAT1A variants have been associated with a more favorable profile—such as lower likelihood of high blood pressure and stroke—and less DNA damage, particularly when vitamin B6 status is higher. This is why a DNA-based approach paired with nutrition insights can be especially valuable.
: Based on your MAT1A (Methylation) results, you’ll receive 4 personalized recommendations focused on actionable steps you can take now. These include dietary and supplement recommendations tailored to your genotype, with guidance that may address methylation support, homocysteine-related nutrition strategies, and key cofactors such as folate and vitamin B6. Your report helps you prioritize the most relevant changes for your biology—rather than using a one-size-fits-all methylation plan.
: MAT1A influences production of SAM-e, which is central to methylation pathways that intersect with homocysteine metabolism. Research has reported that a specific MAT1A variant (rs3851059) was associated with higher homocysteine levels when folate status was low, and in the same study this pattern corresponded to substantially higher odds of stroke. Another study suggested the relationship between this variant and elevated homocysteine may be more apparent in people with higher fat intake. Importantly, these findings highlight that risk is not determined by genes alone—nutrient status and dietary patterns can modify how a variant expresses—making personalized, nutrition-based recommendations especially useful.
: MAT1A genetic testing can indicate whether you may have variants associated with differences in methylation efficiency and related nutrient needs. Because studies link certain MAT1A variants with homocysteine levels and cardiovascular-related outcomes (including blood pressure and stroke risk in specific contexts), your results can help you focus on the nutrition levers most likely to matter for you. This report translates your MAT1A genotype into personalized dietary and supplement recommendations—such as optimizing folate and vitamin B6 status—so you can support methylation and heart & blood vessel health with a plan built around your DNA.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.89 out of 5 based on 9 customer ratings

4.9 (10 reviews)

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Linda W.

Rated 5 out of 5
Bought this because my mom has a history of B vitamin deficiencies and I worried I might too. It really helped me figure out my own risks and what changes to make with my diet and supplements.
Marco S.

Rated 4 out of 5
Ho 46 anni e ho comprato MAT1A (Methylation) per capire meglio la parte “methylation” legata alla nutrizione, visto che in famiglia ci sono stati problemi di omocisteina alta. Il report è chiaro e pratico, mi è piaciuto che distingua tra methylfolate, vitamina B6 e SAM-e, con avvertenze sensate. Ho ridotto i grassi più pesanti e ho iniziato B6, e mi sento meno appesantita dopo i pasti. Do 4 stelle solo perché avrei voluto più esempi di menu e timing dei supplementi.
Mason C.

Rated 5 out of 5
As a 33 year old endurance runner, I kept hitting a weird wall with energy and recovery even though my macros looked fine. The MAT1A (Methylation) report connected the dots between methylation support and how I respond to certain nutrition choices. I started methylfolate and a low dose pyridoxine (B6), and I used the guidance to trial SAM-e only on heavier training weeks. The “limit dietary fats” section also pushed me to clean up my late night takeout. Within a month my afternoon slump eased and my sleep felt deeper.
Diana E.

Rated 5 out of 5
Honestly, the methylation info here totally made supplement shopping way easier for me!
Mina H.

Rated 5 out of 5
Needed this.

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MAT1A (Methylation)

Product features

Understanding Your MAT1A (Methylation) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the MAT1A (Methylation) gene do?

Why is the MAT1A (Methylation) gene important?

What can I do based on my MAT1A (Methylation) results?

How is MAT1A (Methylation) linked to homocysteine and stroke risk?

What do MAT1A (Methylation) genetic testing results tell me about nutrition and heart health?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers