What does the IDO (Kynurenine) gene do?

The IDO (Kynurenine) gene provides instructions for making an enzyme called indoleamine 2,3-dioxygenase (IDO). This enzyme starts the kynurenine pathway, which breaks down tryptophan—an essential amino acid you get from food—into downstream compounds. Beyond metabolism, IDO also helps regulate immune activity by influencing tryptophan availability, which can affect how strongly certain immune cells respond during inflammation.

Why is the IDO (Kynurenine) gene important?

IDO (Kynurenine) is important because it sits at the intersection of nutrition (tryptophan intake), immune signaling (inflammation can increase IDO activity), and downstream metabolic products that may influence broader health. Genetic variants can be associated with differences in IDO levels or activity, which may shift how your body processes tryptophan under stress or inflammatory conditions. Research also links genetically higher IDO levels with protective associations for certain conditions (including ischemic heart disease, type 2 diabetes, and prostate cancer), highlighting why understanding your personal genetics can add useful context to lifestyle decisions.

What can I do based on my IDO (Kynurenine) results?

Based on your IDO (Kynurenine) results, you’ll receive 3 personalized recommendations designed to be actionable and genotype-informed. These include dietary and supplement-focused guidance to help support healthy tryptophan metabolism and a balanced inflammatory response—both relevant to nerve health. Your report translates your SNP findings into practical next steps you can implement in daily routines, and it can also help you decide what to prioritize when discussing labs, supplements, or nutrition plans with a healthcare professional.

How does the kynurenine pathway relate to nerve health and inflammation?

The kynurenine pathway is the main route for breaking down tryptophan, and it becomes more active in response to inflammatory signals. Because inflammation and immune activity can influence nervous system comfort and function, understanding how your body may route tryptophan through this pathway can be relevant for nerve health goals. The IDO enzyme is a key “gatekeeper” step in that pathway, and genetic differences associated with IDO levels may help explain why some people are more sensitive to stress- and inflammation-related shifts in metabolism. Your DNA report uses your IDO variants to personalize dietary and supplement strategies that support balanced immune signaling and overall metabolic resilience.

What can an IDO (Kynurenine) genetic test tell me about tryptophan metabolism?

An IDO (Kynurenine) genetic test can identify specific SNPs associated with differences in IDO expression or activity, which may influence how readily your body initiates tryptophan breakdown through the kynurenine pathway—especially during times of inflammation or stress. While genetics is only one part of the picture (diet, immune status, and lifestyle also matter), knowing your IDO variants can help you personalize nutrition and supplement choices. This report analyzes 3 SNPs and provides 3 tailored recommendations, giving you a practical, DNA-based starting point for supporting nerve health and immune-metabolic balance.

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IDO (Kynurenine)

Rated 4.80 out of 5 based on 5 customer ratings

4.8 (6 reviews)

IDO (Kynurenine)

Rated 4.80 out of 5 based on 5 customer ratings

4.8 (6 reviews)

The report provides up to 3 personalized recommendations based on 3 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes 3 Genetic Variants

Up to 3 DNA-Based, Science-Backed Recommendations

IDO (Kynurenine)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your IDO (Kynurenine) Variants: A DNA Gene Report

Do you ever wonder why stress seems to hit your mood and nerve comfort so differently than it does for other people? Curious how your body “decides” whether to use tryptophan for supportive pathways versus breaking it down during inflammation? What if a few small DNA differences in your IDO (Kynurenine) gene could help explain how your immune signals, nutrition, and nervous system support are connected? Your IDO (Kynurenine) Gene Report helps you understand how your personal variants may influence this key metabolic and immune-regulating pathway—so you can make more targeted choices for nerve health.

Key Report Highlights

This report analyzes 3 genetic variants (SNPs) in the IDO (Kynurenine) gene and translates them into 3 personalized recommendations tailored to your genotype. IDO (indoleamine 2,3-dioxygenase) is the enzyme that initiates the kynurenine pathway—the primary route for breaking down tryptophan—and it plays an important role in immune regulation and tolerance. A compelling takeaway: IDO activity can be strongly influenced by inflammatory signals, meaning your immune state and lifestyle factors may shift how tryptophan is metabolized in ways that can matter for whole-body resilience, including nerve health.

Personalized, Actionable Recommendations

Your recommendations are personalized to your IDO (Kynurenine) genotype, helping you focus on the levers most relevant to you—especially dietary and supplement strategies that support healthy tryptophan metabolism and balanced inflammatory signaling. Depending on your results, your report may include dietary guidance such as optimizing tryptophan-containing foods within a balanced meal pattern, or nutrition strategies that support a healthy inflammatory response. It may also include supplement-oriented recommendations (when appropriate) aimed at supporting nervous system health and metabolic pathways connected to the kynurenine route—presented as practical, genotype-informed options you can discuss with a clinician if you have medical conditions or take medications.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The IDO (Kynurenine) gene provides instructions for making an enzyme called indoleamine 2,3-dioxygenase (IDO). This enzyme starts the kynurenine pathway, which breaks down tryptophan—an essential amino acid you get from food—into downstream compounds. Beyond metabolism, IDO also helps regulate immune activity by influencing tryptophan availability, which can affect how strongly certain immune cells respond during inflammation.
: IDO (Kynurenine) is important because it sits at the intersection of nutrition (tryptophan intake), immune signaling (inflammation can increase IDO activity), and downstream metabolic products that may influence broader health. Genetic variants can be associated with differences in IDO levels or activity, which may shift how your body processes tryptophan under stress or inflammatory conditions. Research also links genetically higher IDO levels with protective associations for certain conditions (including ischemic heart disease, type 2 diabetes, and prostate cancer), highlighting why understanding your personal genetics can add useful context to lifestyle decisions.
: Based on your IDO (Kynurenine) results, you’ll receive 3 personalized recommendations designed to be actionable and genotype-informed. These include dietary and supplement-focused guidance to help support healthy tryptophan metabolism and a balanced inflammatory response—both relevant to nerve health. Your report translates your SNP findings into practical next steps you can implement in daily routines, and it can also help you decide what to prioritize when discussing labs, supplements, or nutrition plans with a healthcare professional.
: The kynurenine pathway is the main route for breaking down tryptophan, and it becomes more active in response to inflammatory signals. Because inflammation and immune activity can influence nervous system comfort and function, understanding how your body may route tryptophan through this pathway can be relevant for nerve health goals. The IDO enzyme is a key “gatekeeper” step in that pathway, and genetic differences associated with IDO levels may help explain why some people are more sensitive to stress- and inflammation-related shifts in metabolism. Your DNA report uses your IDO variants to personalize dietary and supplement strategies that support balanced immune signaling and overall metabolic resilience.
: An IDO (Kynurenine) genetic test can identify specific SNPs associated with differences in IDO expression or activity, which may influence how readily your body initiates tryptophan breakdown through the kynurenine pathway—especially during times of inflammation or stress. While genetics is only one part of the picture (diet, immune status, and lifestyle also matter), knowing your IDO variants can help you personalize nutrition and supplement choices. This report analyzes 3 SNPs and provides 3 tailored recommendations, giving you a practical, DNA-based starting point for supporting nerve health and immune-metabolic balance.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.80 out of 5 based on 5 customer ratings

4.8 (6 reviews)

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Tony A.

Rated 5 out of 5
After reading, I added 5-HTP and switched to an anti-inflammatory diet as suggested. Two weeks in, my nerve pain flares less often and I feel clearer. Wasn’t sure changing tryptophan would matter but honestly, it did. Good value for actions you can actually take.
Zara P.

Rated 4 out of 5
Kynurenine nerves, needs more charts
Nour S.

Rated 5 out of 5
تعب الأعصاب والتنميل الخفيف كان يزعجني بعد أيام الضغط، وكنت أظنه مجرد قلة نوم. تقرير IDO (Kynurenine) ربط لي بين الالتهاب ومسار التربتوفان بطريقة مفهومة، وشرح لماذا قد أتأثر أكثر. بدأت بتطبيق حمية مضادة للالتهاب، وزدت مصادر التربتوفان من الطعام بدل الاعتماد على وجبات سريعة. جربت 5-HTP بجرعة منخفضة كما اقترح التقرير بعد استشارة طبيبي. خلال أسابيع لاحظت هدوءاً في الإحساس بالوخز وتحسناً في المزاج والنوم. التقرير أعطاني خطوات واضحة وليست عامة.
Mako H.

Rated 5 out of 5
Honestly, I didn’t expect much but learning about my IDO pathway and how it might affect my nerve pain was worth every penny.
Alicia T.

Rated 5 out of 5
Impressed by the scientific depth here. The detailed analysis of the IDO pathway and implications for kynurenine metabolism was above and beyond what I expected from a DNA health tool. Seeing my SNPs connected with tryptophan intake and serotonin conversion really explained some ongoing nerve issues for me. Appreciated the citations and mechanistic breakdowns throughout.

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IDO (Kynurenine)

Product features

Understanding Your IDO (Kynurenine) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the IDO (Kynurenine) gene do?

Why is the IDO (Kynurenine) gene important?

What can I do based on my IDO (Kynurenine) results?

How does the kynurenine pathway relate to nerve health and inflammation?

What can an IDO (Kynurenine) genetic test tell me about tryptophan metabolism?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers