What does the HTR4 (Serotonin) gene do?

The HTR4 gene provides instructions for making the 5-HT4 serotonin receptor. Think of this receptor as a “receiver” that helps your cells detect and respond to serotonin. When serotonin activates 5-HT4, it can stimulate an internal signaling pathway (cAMP) that influences how cells communicate—especially in the brain, but also in areas like the gut and heart.

Why is the HTR4 (Serotonin) gene important?

HTR4 is important because serotonin signaling plays a central role in mental health and emotional regulation. Research has linked common variants in HTR4 to mood-related traits and differences in antidepressant treatment outcomes. For example, one studied variant (rs1345697) has been associated with lower symptom improvement and remission rates after 6 months of antidepressant treatment in depressed patients, while another (rs6889822) has been associated with increased risk of mood swings. While the exact effect of these variants on receptor activity isn’t fully known yet, knowing your genotype can help you make more informed, personalized lifestyle choices and have more targeted conversations with your clinician.

What can I do based on my HTR4 (Serotonin) results?

Your HTR4 results translate into 3 personalized recommendations, focused on actionable dietary and supplement guidance. Depending on your genotype, your plan may emphasize specific nutrition priorities that support neurotransmitter-related pathways, along with supplement options that may be relevant for mood support. The goal is to give you practical next steps that align with your DNA—so you can build a routine that’s more personalized than generic mental wellness advice.

How does the HTR4 (serotonin receptor) gene affect mood and mental health?

HTR4 encodes the 5-HT4 serotonin receptor, which helps cells respond to serotonin through cAMP-based signaling. Because serotonin signaling is tied to mood regulation, stress response, and emotional processing, differences in HTR4 can be relevant to mental health. Studies have associated certain common HTR4 variants with mood-related traits (such as mood swings) and with differences in antidepressant outcomes. Importantly, genetics is only one piece of the puzzle—sleep, stress, diet, medications, and other genes also influence mental health—but HTR4 testing can provide a personalized starting point for targeted lifestyle support.

What can an HTR4 genetic test tell me about antidepressant response?

An HTR4-focused genetic test can identify whether you carry specific variants that research has associated with antidepressant treatment outcomes. In one study of depressed patients, the major ‘C’ allele of rs1345697 was associated with lower symptom improvement and remission rates after 6 months of antidepressant treatment. This does not mean a medication will or won’t work for you, but it can add context for discussions with a healthcare professional and can support a more personalized approach—combining clinician guidance with tailored diet and supplement recommendations based on your HTR4 genotype.

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HTR4 (Serotonin)

Rated 4.69 out of 5 based on 13 customer ratings

4.7 (14 reviews)

HTR4 (Serotonin)

Rated 4.69 out of 5 based on 13 customer ratings

4.7 (14 reviews)

The report provides up to 3 personalized recommendations based on 2 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Trusted by 200,000+ users & 2,000+ doctors

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Analyzes 2 Genetic Variants

Up to 3 DNA-Based, Science-Backed Recommendations

HTR4 (Serotonin)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your HTR4 (Serotonin) Variants: A DNA Gene Report

Do you ever wonder why your mood can feel steady one month and unpredictable the next? Have you tried lifestyle changes or medications and felt like the results were inconsistent? Your HTR4 (Serotonin) gene helps build a serotonin receptor (5-HT4) involved in how your body responds to serotonin—a key chemical messenger linked to mental well-being—so understanding your HTR4 variants can add clarity to what your brain and body may need for better support.

Key Report Highlights

This HTR4 (Serotonin) Gene Report analyzes 2 specific genetic variants (SNPs) in the HTR4 gene and turns your results into 3 personalized recommendations. HTR4 encodes the 5-HT4 serotonin receptor, part of a receptor family that helps cells respond to serotonin by triggering cAMP signaling—an important pathway for communication in the nervous system. Compellingly, HTR4 is expressed not only in key brain regions involved in motivation and reward (including the nucleus accumbens and basal ganglia), but also in the gastrointestinal tract—underscoring how closely mood and gut signaling can be connected.

Personalized, Actionable Recommendations

Your recommendations are personalized to your HTR4 genotype—because the same diet or supplement routine doesn’t work the same way for everyone. Based on how your variants relate to mood-related traits and treatment response signals in the research, the report provides targeted dietary and supplement recommendations (3 total). Examples of the kind of guidance you may see include food-based strategies that support healthy neurotransmitter balance (such as prioritizing specific nutrient-dense protein sources) and supplement suggestions commonly used to support stress resilience or serotonin-related pathways—tailored to your results and safety considerations.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The HTR4 gene provides instructions for making the 5-HT4 serotonin receptor. Think of this receptor as a “receiver” that helps your cells detect and respond to serotonin. When serotonin activates 5-HT4, it can stimulate an internal signaling pathway (cAMP) that influences how cells communicate—especially in the brain, but also in areas like the gut and heart.
: HTR4 is important because serotonin signaling plays a central role in mental health and emotional regulation. Research has linked common variants in HTR4 to mood-related traits and differences in antidepressant treatment outcomes. For example, one studied variant (rs1345697) has been associated with lower symptom improvement and remission rates after 6 months of antidepressant treatment in depressed patients, while another (rs6889822) has been associated with increased risk of mood swings. While the exact effect of these variants on receptor activity isn’t fully known yet, knowing your genotype can help you make more informed, personalized lifestyle choices and have more targeted conversations with your clinician.
: Your HTR4 results translate into 3 personalized recommendations, focused on actionable dietary and supplement guidance. Depending on your genotype, your plan may emphasize specific nutrition priorities that support neurotransmitter-related pathways, along with supplement options that may be relevant for mood support. The goal is to give you practical next steps that align with your DNA—so you can build a routine that’s more personalized than generic mental wellness advice.
: HTR4 encodes the 5-HT4 serotonin receptor, which helps cells respond to serotonin through cAMP-based signaling. Because serotonin signaling is tied to mood regulation, stress response, and emotional processing, differences in HTR4 can be relevant to mental health. Studies have associated certain common HTR4 variants with mood-related traits (such as mood swings) and with differences in antidepressant outcomes. Importantly, genetics is only one piece of the puzzle—sleep, stress, diet, medications, and other genes also influence mental health—but HTR4 testing can provide a personalized starting point for targeted lifestyle support.
: An HTR4-focused genetic test can identify whether you carry specific variants that research has associated with antidepressant treatment outcomes. In one study of depressed patients, the major ‘C’ allele of rs1345697 was associated with lower symptom improvement and remission rates after 6 months of antidepressant treatment. This does not mean a medication will or won’t work for you, but it can add context for discussions with a healthcare professional and can support a more personalized approach—combining clinician guidance with tailored diet and supplement recommendations based on your HTR4 genotype.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.69 out of 5 based on 13 customer ratings

4.7 (14 reviews)

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Derek V.

Rated 5 out of 5
I’m 42, and mood swings run in my family. The HTR4 (Serotonin) report helped me connect my “wired but low” days to serotonin pathways without making it feel like doom. I followed the plan step by step, first food changes, then a probiotic, then a cautious 5-HTP trial. The biggest win was sleep, I stopped waking at 3 a.m. with racing thoughts. The report also nudged me to track reactions, which helped me notice coffee was amplifying the problem more than I realized.
Carl X.

Rated 5 out of 5
After reading everything, I started taking a probiotic daily and added more tryptophan-rich foods to my meals. I also tried 5-HTP for two weeks. I actually noticed that my sleep felt better, and my mood was less up and down not perfect but I’m happy with it.
Shane L.

Rated 5 out of 5
I always wondered if my serotonin levels had anything to do with my mood swings, and this finally connected the dots for me.
Ravi K.

Rated 4 out of 5
I’m a therapist-in-training and bought the HTR4 (Serotonin) report to understand my own stress sensitivity. The explanations around serotonin signaling were easy to follow, and the recommendations felt practical. I tried increasing dietary tryptophan at dinner and adding a probiotic, and my afternoon irritability softened within two weeks. I’m giving four stars because I wanted clearer guidance on when 5-HTP is appropriate versus when to avoid it, plus a few more references for the gene variants discussed.
Rowan R.

Rated 5 out of 5
Tryptophan tweak, steadier mood.

HTR4 (Serotonin)

Product features

Understanding Your HTR4 (Serotonin) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the HTR4 (Serotonin) gene do?

Why is the HTR4 (Serotonin) gene important?

What can I do based on my HTR4 (Serotonin) results?

How does the HTR4 (serotonin receptor) gene affect mood and mental health?

What can an HTR4 genetic test tell me about antidepressant response?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers