What does the CTLA4 (Autoimmunity) gene do?

The CTLA4 (Autoimmunity) gene provides instructions for making CTLA-4, a protein that acts like an immune “brake.” It helps regulate T-cells so your immune system can respond to threats without staying stuck in an overly activated state. CTLA4 works in balance with other signals (like CD28, which stimulates T-cells) to keep immune responses appropriately controlled.

Why is the CTLA4 (Autoimmunity) gene important?

CTLA4 is important because it helps prevent excessive immune activation. Certain genetic variants in CTLA4 have been associated in research with altered CTLA4 levels or function, which may shift how strongly the immune system is restrained. These shifts have been linked to higher susceptibility patterns for several autoimmune conditions in studies, including autoimmune thyroid disease, type 1 diabetes, rheumatoid arthritis, lupus, celiac disease, ulcerative colitis, and multiple sclerosis.

What can I do based on my CTLA4 (Autoimmunity) results?

Based on your CTLA4 (Autoimmunity) results, you’ll receive 1 personalized recommendation focused on dietary action steps. The goal is to help you support a healthier inflammatory response and immune balance in a way that fits your genotype. Your report translates your specific CTLA4 variant findings into practical guidance you can apply to everyday food choices and routines.

Which CTLA4 variants are linked to autoimmune risk?

Research has identified several CTLA4 variants associated with autoimmune susceptibility patterns. One of the most studied is rs231775 (A49G), where the minor G allele has been associated with reduced CTLA4 expression and increased risk signals across multiple autoimmune conditions in studies (including autoimmune thyroid disease, type 1 diabetes, rheumatoid arthritis, lupus, and others). Another well-researched variant is rs3087243 (CT60), where the major G allele has been linked to lower levels of a soluble CTLA4 isoform and increased risk associations for conditions such as rheumatoid arthritis and autoimmune thyroid disease. Additional variants discussed in the report include rs231779 (minor T allele associated with Graves’ disease risk in studies) and rs11571302 (major G allele associated with rheumatoid arthritis risk in studies). Your report looks at your specific combination across all 4 SNPs to provide a personalized interpretation.

What can a CTLA4 genetic test tell me about inflammation and autoimmunity?

A CTLA4 genetic test can reveal whether you carry specific variants that research has associated with differences in immune “checkpoint” signaling—one of the mechanisms that helps prevent immune overactivity. While genetics do not diagnose autoimmune disease, CTLA4 results can help you understand inherited tendencies related to immune regulation and inflammation. This report analyzes 4 CTLA4 SNPs and converts your genotype into an easy-to-understand summary plus 1 personalized dietary recommendation, giving you practical, DNA-informed steps you can use to support immune balance alongside your broader health plan.

Save $30

CTLA4 (Autoimmunity)

Rated 4.70 out of 5 based on 10 customer ratings

4.7 (11 reviews)

CTLA4 (Autoimmunity)

Rated 4.70 out of 5 based on 10 customer ratings

4.7 (11 reviews)

The report provides up to 1 personalized recommendations based on 4 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

$59

$29

Save $30

Add to cart Added

Trusted by 200,000+ users & 2,000+ doctors

Proven track record: 3+ million analyses delivered

Analyzes 4 Genetic Variants

Up to 1 DNA-Based, Science-Backed Recommendations

CTLA4 (Autoimmunity)

$59 $29

Add to cart Added

Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your CTLA4 (Autoimmunity) Variants: A DNA Gene Report

Have you ever wondered why your immune system seems to “overreact,” or why autoimmune conditions can run in families even when lifestyles differ? What if a key immune “brake” in your body is naturally a bit stronger—or weaker—based on your DNA? The CTLA4 (Autoimmunity) gene helps keep immune T-cells in check, and understanding your CTLA4 variants can offer meaningful insight into your personal inflammation and autoimmunity tendencies—so you can make more informed, proactive health choices.

Key Report Highlights

Your CTLA4 (Autoimmunity) Gene Report analyzes 4 clinically studied genetic variants (SNPs) linked to immune regulation and autoimmune risk patterns, then translates your results into 1 personalized, DNA-based recommendation. CTLA4 codes for an immune “checkpoint” protein that helps prevent T-cells from becoming overactive—an important influence on immune balance. Research shows that when CTLA4 signaling is reduced, the immune system can become more reactive, which helps explain why certain CTLA4 variants have been associated with autoimmune conditions in multiple studies.

Personalized, Actionable Recommendations

Your recommendations are personalized to your CTLA4 (Autoimmunity) genotype—so the guidance you receive reflects your specific variant pattern rather than generic wellness tips. This report includes 1 tailored dietary recommendation designed to support healthy immune balance and inflammation control. Depending on your results, examples of advice may include emphasizing anti-inflammatory dietary patterns (e.g., prioritizing omega-3-rich foods and polyphenol-rich fruits/vegetables) and reducing common pro-inflammatory triggers (such as ultra-processed foods or excess added sugars), with practical, easy-to-follow next steps.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The CTLA4 (Autoimmunity) gene provides instructions for making CTLA-4, a protein that acts like an immune “brake.” It helps regulate T-cells so your immune system can respond to threats without staying stuck in an overly activated state. CTLA4 works in balance with other signals (like CD28, which stimulates T-cells) to keep immune responses appropriately controlled.
: CTLA4 is important because it helps prevent excessive immune activation. Certain genetic variants in CTLA4 have been associated in research with altered CTLA4 levels or function, which may shift how strongly the immune system is restrained. These shifts have been linked to higher susceptibility patterns for several autoimmune conditions in studies, including autoimmune thyroid disease, type 1 diabetes, rheumatoid arthritis, lupus, celiac disease, ulcerative colitis, and multiple sclerosis.
: Based on your CTLA4 (Autoimmunity) results, you’ll receive 1 personalized recommendation focused on dietary action steps. The goal is to help you support a healthier inflammatory response and immune balance in a way that fits your genotype. Your report translates your specific CTLA4 variant findings into practical guidance you can apply to everyday food choices and routines.
: Research has identified several CTLA4 variants associated with autoimmune susceptibility patterns. One of the most studied is rs231775 (A49G), where the minor G allele has been associated with reduced CTLA4 expression and increased risk signals across multiple autoimmune conditions in studies (including autoimmune thyroid disease, type 1 diabetes, rheumatoid arthritis, lupus, and others). Another well-researched variant is rs3087243 (CT60), where the major G allele has been linked to lower levels of a soluble CTLA4 isoform and increased risk associations for conditions such as rheumatoid arthritis and autoimmune thyroid disease. Additional variants discussed in the report include rs231779 (minor T allele associated with Graves’ disease risk in studies) and rs11571302 (major G allele associated with rheumatoid arthritis risk in studies). Your report looks at your specific combination across all 4 SNPs to provide a personalized interpretation.
: A CTLA4 genetic test can reveal whether you carry specific variants that research has associated with differences in immune “checkpoint” signaling—one of the mechanisms that helps prevent immune overactivity. While genetics do not diagnose autoimmune disease, CTLA4 results can help you understand inherited tendencies related to immune regulation and inflammation. This report analyzes 4 CTLA4 SNPs and converts your genotype into an easy-to-understand summary plus 1 personalized dietary recommendation, giving you practical, DNA-informed steps you can use to support immune balance alongside your broader health plan.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.70 out of 5 based on 10 customer ratings

4.7 (11 reviews)

Share your thoughts

If you've used this product, share your thoughts with other customers

Only customers who purchased this product can leave reviews

Samantha R.

Rated 5 out of 5
I ordered the CTLA4 (Autoimmunity) report because autoimmune issues run in my family, and I wanted something more concrete than random blogs. It explained what CTLA4 does in immune “braking” in plain language, then tied it to practical steps. The biggest change for me was the Reduce Arachidonic Acid Intake suggestion, I cut back on frequent processed meats and certain cooking oils and leaned harder into olive oil and fish. Within a few weeks my morning finger stiffness felt less persistent, and I had a clearer plan to discuss with my doctor.
Renato B.

Rated 5 out of 5
Compared to the info you get from blogs or random internet searches, this had real actionable steps. It was focused on my genetics, not just generic advice. Stood out because it explained why certain things like lowering arachidonic acid matters for me. Worth checking out.
Deshawn T.

Rated 4 out of 5
CTLA4, clearer immune compass.
Dustin P.

Rated 5 out of 5
Bien diseñado y explicado. Me ayudó a entender mis riesgos de autoinmunidad y qué acciones tomar, especialmente sobre la alimentación. Lo recomiendo para quien quiera personalizar sus cuidados de salud.
James X.

Rated 5 out of 5
Didn’t really trust DNA reports before but this one was different. The recommendations about reducing certain fats actually lined up with what my doctor suggested. It wasn’t too technical but gave me enough details to feel like it was tailored to me. Glad I gave it a shot.

1 2 3

CTLA4 (Autoimmunity)

Product features

Understanding Your CTLA4 (Autoimmunity) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the CTLA4 (Autoimmunity) gene do?

Why is the CTLA4 (Autoimmunity) gene important?

What can I do based on my CTLA4 (Autoimmunity) results?

Which CTLA4 variants are linked to autoimmune risk?

What can a CTLA4 genetic test tell me about inflammation and autoimmunity?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers