What does the PHACTR1 (Cardiovascular) gene do?

The PHACTR1 (Cardiovascular) gene provides instructions for a protein that helps regulate cell structure (the actin cytoskeleton) and supports endothelial cell survival—the cells that line your blood vessels. It also influences PP1 activity, which can affect NOS3 enzymes and nitric oxide (NO) production. Because NO helps blood vessels relax and function normally, PHACTR1 is relevant to vascular performance and cardiovascular biology.

Why is the PHACTR1 (Cardiovascular) gene important?

PHACTR1 (Cardiovascular) is important because certain variants have been associated in research with cardiovascular outcomes such as coronary artery disease, coronary artery calcification, coronary atherosclerosis, and myocardial infarction. Some variants may shift PHACTR1 expression in vascular cells and influence pathways tied to endothelial function and nitric oxide signaling. Notably, associations can be complex—some variants linked to higher risk for one outcome have also been associated with lower risk for others—so a focused, variant-specific interpretation matters.

What can I do based on my PHACTR1 (Cardiovascular) results?

Based on your PHACTR1 (Cardiovascular) results, you’ll receive 4 personalized recommendations that translate your genotype into actionable next steps. These include dietary recommendations (e.g., food patterns and key nutrients that support vascular and lipid-related pathways) and supplement recommendations (e.g., targeted options that may support endothelial function or cardiovascular markers). Your report is designed to help you prioritize what’s most relevant to your genetics while keeping the guidance practical and easy to implement.

Which PHACTR1 variants are linked to coronary artery disease and heart attack risk?

Research has highlighted PHACTR1 variants such as rs9349379 and rs12526453 in relation to cardiovascular outcomes. The minor ‘G’ allele of rs9349379 has been associated with increased risk of coronary artery disease and myocardial infarction in multiple studies, and has also been linked to coronary artery calcification (with stronger associations reported in smokers), coronary atherosclerosis, and coronary microvascular dysfunction. Another variant, rs12526453, has been associated with increased risk of myocardial infarction and coronary artery disease, and has also been linked to higher LDL cholesterol and ApoB levels, which may help explain part of the observed risk associations. Your report interprets the specific variants analyzed and explains what your genotype may suggest in the context of these findings.

What do I get with a PHACTR1 (Cardiovascular) genetic test report?

You receive a DNA-based interpretation focused on the PHACTR1 (Cardiovascular) gene, including analysis of 2 specific SNPs and a clear summary of what the research suggests about those variants and cardiovascular health. The report also provides 4 personalized recommendations based on your genotype, with actionable dietary and supplement guidance. The goal is to help you move from raw genetic data to practical, personalized steps that support heart and blood vessel health.

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PHACTR1 (Cardiovascular)

Rated 4.83 out of 5 based on 12 customer ratings

4.8 (13 reviews)

PHACTR1 (Cardiovascular)

Rated 4.83 out of 5 based on 12 customer ratings

4.8 (13 reviews)

The report provides up to 4 personalized recommendations based on 2 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Trusted by 200,000+ users & 2,000+ doctors

Proven track record: 3+ million analyses delivered

Analyzes 2 Genetic Variants

Up to 4 DNA-Based, Science-Backed Recommendations

PHACTR1 (Cardiovascular)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your PHACTR1 (Cardiovascular) Variants: A DNA Gene Report

Have you ever wondered why heart disease risk can run in families even when lifestyles look similar? Are you curious whether your blood vessel function and nitric oxide signaling might be influenced by your DNA? What if understanding your PHACTR1 (Cardiovascular) variants could help you make more targeted choices for your heart and blood vessels? The PHACTR1 gene is involved in how endothelial cells (the lining of your arteries) function and survive—so learning your genetic pattern can add a powerful layer of personalization to your cardiovascular prevention plan.

Key Report Highlights

This PHACTR1 (Cardiovascular) Gene Report analyzes 2 well-studied genetic variants (SNPs) and turns your results into 4 personalized recommendations. PHACTR1 helps regulate PP1 activity, which can influence NOS3 enzyme activity and nitric oxide (NO) production—an important pathway for healthy blood vessel tone and endothelial function. Compelling fact: changes in this pathway can affect how efficiently your arteries relax and respond to stressors, which is why PHACTR1 variants have been linked in research to coronary artery disease and myocardial infarction risk.

Personalized, Actionable Recommendations

Your recommendations are tailored to your specific PHACTR1 (Cardiovascular) genotype—so the guidance is designed to match the biology suggested by your variants, rather than generic heart-health advice. You’ll receive dietary and supplement recommendations aligned to cardiovascular-supportive pathways such as endothelial function, lipid balance, and overall vascular resilience. For example, your plan may highlight nutrition strategies that support healthy nitric oxide availability (e.g., prioritizing nitrate-rich vegetables) and may include supplement guidance commonly used to support cardiovascular markers (with dosing and safety notes where appropriate), personalized to your genetic findings.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The PHACTR1 (Cardiovascular) gene provides instructions for a protein that helps regulate cell structure (the actin cytoskeleton) and supports endothelial cell survival—the cells that line your blood vessels. It also influences PP1 activity, which can affect NOS3 enzymes and nitric oxide (NO) production. Because NO helps blood vessels relax and function normally, PHACTR1 is relevant to vascular performance and cardiovascular biology.
: PHACTR1 (Cardiovascular) is important because certain variants have been associated in research with cardiovascular outcomes such as coronary artery disease, coronary artery calcification, coronary atherosclerosis, and myocardial infarction. Some variants may shift PHACTR1 expression in vascular cells and influence pathways tied to endothelial function and nitric oxide signaling. Notably, associations can be complex—some variants linked to higher risk for one outcome have also been associated with lower risk for others—so a focused, variant-specific interpretation matters.
: Based on your PHACTR1 (Cardiovascular) results, you’ll receive 4 personalized recommendations that translate your genotype into actionable next steps. These include dietary recommendations (e.g., food patterns and key nutrients that support vascular and lipid-related pathways) and supplement recommendations (e.g., targeted options that may support endothelial function or cardiovascular markers). Your report is designed to help you prioritize what’s most relevant to your genetics while keeping the guidance practical and easy to implement.
: Research has highlighted PHACTR1 variants such as rs9349379 and rs12526453 in relation to cardiovascular outcomes. The minor ‘G’ allele of rs9349379 has been associated with increased risk of coronary artery disease and myocardial infarction in multiple studies, and has also been linked to coronary artery calcification (with stronger associations reported in smokers), coronary atherosclerosis, and coronary microvascular dysfunction. Another variant, rs12526453, has been associated with increased risk of myocardial infarction and coronary artery disease, and has also been linked to higher LDL cholesterol and ApoB levels, which may help explain part of the observed risk associations. Your report interprets the specific variants analyzed and explains what your genotype may suggest in the context of these findings.
: You receive a DNA-based interpretation focused on the PHACTR1 (Cardiovascular) gene, including analysis of 2 specific SNPs and a clear summary of what the research suggests about those variants and cardiovascular health. The report also provides 4 personalized recommendations based on your genotype, with actionable dietary and supplement guidance. The goal is to help you move from raw genetic data to practical, personalized steps that support heart and blood vessel health.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.83 out of 5 based on 12 customer ratings

4.8 (13 reviews)

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Ted Y.

Rated 4 out of 5
At first I thought this sort of thing was a gimmick, but after reading through it and seeing some tailored dietary tips, I changed my mind. The recommendations about olive polyphenols and fat types felt relevant. Only thing, wish the layout was easier to follow in spots.
Devin E.

Rated 5 out of 5
I’m in my 40s with a family history of early heart issues, and this PHACTR1 (Cardiovascular) report gave me a concrete plan instead of vague warnings. The sections on limiting saturated fat and avoiding trans fats were especially practical, down to which packaged foods to watch. I also started prioritizing dietary polyphenols, berries, cocoa, and more extra virgin olive oil, then added an olive polyphenols supplement as suggested. After about six weeks, my lipid panel improved slightly and I feel more in control of my cardiovascular risk.
Wendy G.

Rated 5 out of 5
I really don’t write reviews usually, but this left me kind of amazed! Learned so much about my heart risks and just how foods I already like can actually help. Actually felt doable, not intimidating. Glad I tried it.
Trent R.

Rated 5 out of 5
PHACTR1 (Cardiovascular) pushed me to cut saturated fat and add polyphenol rich foods. My blood pressure readings have been steadier this month.
Dawn X.

Rated 5 out of 5
I was honestly expecting something generic, but this actually gave me some useful info about my heart health. More helpful than expected.

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PHACTR1 (Cardiovascular)

Product features

Understanding Your PHACTR1 (Cardiovascular) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the PHACTR1 (Cardiovascular) gene do?

Why is the PHACTR1 (Cardiovascular) gene important?

What can I do based on my PHACTR1 (Cardiovascular) results?

Which PHACTR1 variants are linked to coronary artery disease and heart attack risk?

What do I get with a PHACTR1 (Cardiovascular) genetic test report?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers