What does the CELSR2-PSRC1-SORT1 (Cardiovascular) gene do?

The CELSR2-PSRC1-SORT1 (Cardiovascular) gene cluster is a group of nearby genes on chromosome 1 that influence important cellular processes. CELSR2 is thought to play a role in cell-to-cell communication, PSRC1 helps regulate cell division, and SORT1 (sortilin 1) helps route and clear proteins inside cells and at the cell surface. Together, this region is strongly linked in research to how the body regulates blood lipids such as LDL cholesterol and ApoB—factors that matter for cardiovascular health.

Why is the CELSR2-PSRC1-SORT1 (Cardiovascular) gene important?

This gene cluster is important because certain genetic variants in the region have been associated with higher total cholesterol, LDL cholesterol, and ApoB, as well as inflammatory markers like CRP in some studies. Two widely studied variants (rs599839 and rs646776) are often inherited together and have been linked to increased risk of coronary artery disease and myocardial infarction. Knowing your genetic variants doesn’t diagnose disease, but it can help clarify whether you may have an inherited tendency toward less favorable lipid profiles—so you can focus on prevention and monitoring earlier and more precisely.

What can I do based on my CELSR2-PSRC1-SORT1 (Cardiovascular) results?

Based on your results, the report provides 5 personalized recommendations across dietary, drug, and supplement categories. Depending on your genotype, this may include targeted nutrition priorities to support healthier LDL/ApoB levels, discussion points to bring to your healthcare provider about lipid management strategies, and supplement options that align with your genetic profile and cardiovascular goals. The aim is to turn your DNA insights into practical next steps you can apply alongside standard heart-health care.

How does CELSR2-PSRC1-SORT1 affect LDL cholesterol and heart disease risk?

Research on the CELSR2-PSRC1-SORT1 region shows that certain genetic variants are associated with differences in lipid markers—especially LDL cholesterol and ApoB, which reflect the number of atherogenic (plaque-forming) particles in the bloodstream. Variants such as rs599839 and rs646776 have been linked in multiple studies to higher cholesterol-related markers and increased risk of cardiovascular outcomes like coronary artery disease and myocardial infarction. This report helps you understand whether your genotype may align with those risk patterns and what personalized actions may be most relevant for you.

What will a CELSR2-PSRC1-SORT1 genetic test report tell me about cardiovascular health?

A CELSR2-PSRC1-SORT1 genetic test report interprets your genetic variants in this well-studied cardiovascular region and connects them to evidence-backed health implications—particularly around cholesterol transport (LDL, ApoB) and related risk signals. You’ll receive a clear explanation of what your results may mean, plus 5 personalized recommendations spanning diet, drug considerations to discuss with a clinician, and supplement guidance. It’s designed to complement—not replace—standard lab testing and medical advice by adding a DNA-based layer of personalization to your heart-health plan.

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CELSR2-PSRC1-SORT1 (Cardiovascular)

Rated 4.73 out of 5 based on 11 customer ratings

4.7 (12 reviews)

CELSR2-PSRC1-SORT1 (Cardiovascular)

Rated 4.73 out of 5 based on 11 customer ratings

4.7 (12 reviews)

The report provides up to 5 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Trusted by 200,000+ users & 2,000+ doctors

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Analyzes Key Genetic Variants

Up to 5 DNA-Based, Science-Backed Recommendations

CELSR2-PSRC1-SORT1 (Cardiovascular)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your CELSR2-PSRC1-SORT1 (Cardiovascular) Variants: A DNA Gene Report

Ever wonder why your cholesterol numbers don’t always match your lifestyle—or why heart disease can run in families even when everyone “eats pretty well”? Are you curious whether your DNA may influence how your body handles LDL (“bad”) cholesterol and inflammation over time? The CELSR2-PSRC1-SORT1 (Cardiovascular) gene cluster is one of the most studied genetic regions linked to blood lipids and cardiovascular risk, and understanding your personal genetic variants can help you make more targeted choices for your heart and blood vessels.

Key Report Highlights

This report analyzes genetic variants in the CELSR2-PSRC1-SORT1 (Cardiovascular) gene cluster and translates your results into 5 personalized recommendations. Biologically, this chromosome 1 region includes genes involved in cell-to-cell communication (CELSR2), cell-cycle regulation (PSRC1), and protein sorting/clearance pathways (SORT1). A compelling takeaway: well-researched variants in this region have been associated with differences in LDL cholesterol and ApoB—key markers that influence how cholesterol is transported in the blood and how plaque can develop in arteries.

Personalized, Actionable Recommendations

Your recommendations are personalized to your CELSR2-PSRC1-SORT1 (Cardiovascular) genotype, so the guidance you receive is tailored to what your DNA suggests about lipid handling and cardiovascular risk markers. You’ll get actionable dietary, drug, and supplement recommendations—such as nutrition strategies that support healthier LDL/ApoB levels (for example, optimizing soluble fiber and fat quality) and genotype-informed considerations to discuss with your clinician around lipid-lowering options. Supplement guidance may also include targeted support aligned with your results and overall heart-health goals.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The CELSR2-PSRC1-SORT1 (Cardiovascular) gene cluster is a group of nearby genes on chromosome 1 that influence important cellular processes. CELSR2 is thought to play a role in cell-to-cell communication, PSRC1 helps regulate cell division, and SORT1 (sortilin 1) helps route and clear proteins inside cells and at the cell surface. Together, this region is strongly linked in research to how the body regulates blood lipids such as LDL cholesterol and ApoB—factors that matter for cardiovascular health.
: This gene cluster is important because certain genetic variants in the region have been associated with higher total cholesterol, LDL cholesterol, and ApoB, as well as inflammatory markers like CRP in some studies. Two widely studied variants (rs599839 and rs646776) are often inherited together and have been linked to increased risk of coronary artery disease and myocardial infarction. Knowing your genetic variants doesn’t diagnose disease, but it can help clarify whether you may have an inherited tendency toward less favorable lipid profiles—so you can focus on prevention and monitoring earlier and more precisely.
: Based on your results, the report provides 5 personalized recommendations across dietary, drug, and supplement categories. Depending on your genotype, this may include targeted nutrition priorities to support healthier LDL/ApoB levels, discussion points to bring to your healthcare provider about lipid management strategies, and supplement options that align with your genetic profile and cardiovascular goals. The aim is to turn your DNA insights into practical next steps you can apply alongside standard heart-health care.
: Research on the CELSR2-PSRC1-SORT1 region shows that certain genetic variants are associated with differences in lipid markers—especially LDL cholesterol and ApoB, which reflect the number of atherogenic (plaque-forming) particles in the bloodstream. Variants such as rs599839 and rs646776 have been linked in multiple studies to higher cholesterol-related markers and increased risk of cardiovascular outcomes like coronary artery disease and myocardial infarction. This report helps you understand whether your genotype may align with those risk patterns and what personalized actions may be most relevant for you.
: A CELSR2-PSRC1-SORT1 genetic test report interprets your genetic variants in this well-studied cardiovascular region and connects them to evidence-backed health implications—particularly around cholesterol transport (LDL, ApoB) and related risk signals. You’ll receive a clear explanation of what your results may mean, plus 5 personalized recommendations spanning diet, drug considerations to discuss with a clinician, and supplement guidance. It’s designed to complement—not replace—standard lab testing and medical advice by adding a DNA-based layer of personalization to your heart-health plan.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.73 out of 5 based on 11 customer ratings

4.7 (12 reviews)

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Devon S.

Rated 4 out of 5
Clear, actionable heart steps.
James W.

Rated 5 out of 5
I bought CELSR2-PSRC1-SORT1 (Cardiovascular) after my annual labs showed creeping LDL and my dad’s early heart disease kept nagging me. The report didn’t just warn me, it gave a tight plan. I started using a plant sterols and stanols supplement, swapped butter and coconut-heavy snacks for more oleic acid from olive oil, and got strict about avoiding trans fats. Within two months my follow up panel improved, and I finally understood why “healthy” keto was backfiring for me. The ezetimibe section also helped me prepare smarter questions for my clinician.
Said C.

Rated 5 out of 5
After reading, I started taking plant sterol supplements and swapped in more olive oil for cooking. I also cut back on the trans fats like it suggested and saw my cholesterol drop a bit at my next checkup. Definitely made changes that worked for me.
Priya D.

Rated 5 out of 5
SORT1 clues, calmer arteries.
Lisa U.

Rated 5 out of 5
My dad had heart issues, so I did this to see where I stand. Learned a ton about my own risks and what changes I can make now. Honestly, it made me feel more proactive and gave me talking points for my next doctor visit.

CELSR2-PSRC1-SORT1 (Cardiovascular)

Product features

Understanding Your CELSR2-PSRC1-SORT1 (Cardiovascular) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the CELSR2-PSRC1-SORT1 (Cardiovascular) gene do?

Why is the CELSR2-PSRC1-SORT1 (Cardiovascular) gene important?

What can I do based on my CELSR2-PSRC1-SORT1 (Cardiovascular) results?

How does CELSR2-PSRC1-SORT1 affect LDL cholesterol and heart disease risk?

What will a CELSR2-PSRC1-SORT1 genetic test report tell me about cardiovascular health?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers