What does the SLC22A4 (Gut Inflammation) gene do?

SLC22A4 (also known as OCTN1) provides instructions for making a transporter protein in the gut lining. Think of it as a “gatekeeper” that helps move certain organic compounds from the intestinal environment into cells. By influencing transport of nutrients and antioxidant-related compounds, SLC22A4 can affect cellular stress responses and help support intestinal barrier function.

Why is the SLC22A4 (Gut Inflammation) gene important?

SLC22A4 is important because changes (genetic variants) in this transporter can alter how efficiently key compounds are moved across the intestinal lining. Research links certain SLC22A4 variants—especially the rs1050152 T allele—to higher odds of IBD, particularly Crohn’s disease. Variants may also influence inflammatory signaling, barrier integrity, and dietary tolerance (including how the body absorbs ergothioneine from mushrooms), which can matter for symptom management in susceptible individuals.

What can I do based on my SLC22A4 (Gut Inflammation) results?

Based on your SLC22A4 (Gut Inflammation) results, your report provides 4 personalized recommendations with clear, actionable steps. These include dietary guidance (such as identifying potential trigger foods and tailoring intake of mushroom-derived compounds when relevant) and supplement recommendations aimed at supporting gut barrier function and helping manage inflammation in a way that fits your genetic profile.

Is SLC22A4 linked to Crohn’s disease and IBD risk?

Yes. Research has identified SLC22A4 as a gene associated with susceptibility to inflammatory bowel disease (IBD), particularly Crohn’s disease. One widely discussed variant is rs1050152, where the T allele has been linked to higher odds of IBD in some populations. While genetics do not determine destiny, SLC22A4 results can help explain why certain people may have differences in gut barrier resilience, inflammatory signaling, and responses to dietary compounds—useful context for prevention and symptom-management strategies.

What does SLC22A4 genetic testing tell me about mushroom intolerance or sensitivity?

SLC22A4 helps transport ergothioneine, a compound found in high amounts in mushrooms. Evidence suggests certain SLC22A4 variants can increase ergothioneine transport, which may exacerbate IBD symptoms in some genetically susceptible individuals—even though ergothioneine is generally considered an antioxidant. This report connects your SLC22A4 genetic variants to practical guidance, helping you understand whether mushroom intake could be a relevant dietary variable to monitor as part of a personalized gut health plan.

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SLC22A4 (Gut Inflammation)

Rated 4.88 out of 5 based on 8 customer ratings

4.9 (9 reviews)

SLC22A4 (Gut Inflammation)

Rated 4.88 out of 5 based on 8 customer ratings

4.9 (9 reviews)

The report provides up to 4 personalized recommendations based on your genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes Key Genetic Variants

Up to 4 DNA-Based, Science-Backed Recommendations

SLC22A4 (Gut Inflammation)

$59 $29

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Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your SLC22A4 (Gut Inflammation) Variants: A DNA Gene Report

Do certain foods seem to trigger bloating, cramping, or unpredictable bathroom trips? Have you ever wondered why gut inflammation runs in some families—or why “healthy” foods like mushrooms don’t always agree with you? Your SLC22A4 (Gut Inflammation) gene helps transport key compounds across the intestinal lining, and understanding your SLC22A4 (Gut Inflammation) genetic variants can reveal why your gut barrier, inflammation signals, and food tolerance may respond differently than someone else’s.

Key Report Highlights

This DNA report analyzes genetic variants in the SLC22A4 (Gut Inflammation) gene and translates your results into 4 personalized recommendations. SLC22A4 (formerly OCTN1) encodes a transporter in the intestinal epithelium that supports cellular balance and intestinal barrier function by moving organic compounds (including carnitine and ergothioneine) across cell membranes. A compelling insight: certain SLC22A4 variants are linked to higher odds of inflammatory bowel disease (IBD), particularly Crohn’s disease, and may also influence how strongly you absorb ergothioneine—a mushroom-derived compound that can worsen symptoms for some genetically susceptible individuals.

Personalized, Actionable Recommendations

Your recommendations are tailored to your SLC22A4 (Gut Inflammation) genotype, helping you make more confident choices around gut health, nutrition, inflammation, and autoimmunity. You’ll receive dietary and supplement recommendations designed to support intestinal barrier integrity and manage inflammatory triggers. For example, your report may suggest adjusting mushroom intake if your genetics indicate increased ergothioneine transport, and it may highlight targeted nutritional support strategies (such as gut-supportive nutrients and anti-inflammatory dietary patterns) aligned with your result.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: SLC22A4 (also known as OCTN1) provides instructions for making a transporter protein in the gut lining. Think of it as a “gatekeeper” that helps move certain organic compounds from the intestinal environment into cells. By influencing transport of nutrients and antioxidant-related compounds, SLC22A4 can affect cellular stress responses and help support intestinal barrier function.
: SLC22A4 is important because changes (genetic variants) in this transporter can alter how efficiently key compounds are moved across the intestinal lining. Research links certain SLC22A4 variants—especially the rs1050152 T allele—to higher odds of IBD, particularly Crohn’s disease. Variants may also influence inflammatory signaling, barrier integrity, and dietary tolerance (including how the body absorbs ergothioneine from mushrooms), which can matter for symptom management in susceptible individuals.
: Based on your SLC22A4 (Gut Inflammation) results, your report provides 4 personalized recommendations with clear, actionable steps. These include dietary guidance (such as identifying potential trigger foods and tailoring intake of mushroom-derived compounds when relevant) and supplement recommendations aimed at supporting gut barrier function and helping manage inflammation in a way that fits your genetic profile.
: Yes. Research has identified SLC22A4 as a gene associated with susceptibility to inflammatory bowel disease (IBD), particularly Crohn’s disease. One widely discussed variant is rs1050152, where the T allele has been linked to higher odds of IBD in some populations. While genetics do not determine destiny, SLC22A4 results can help explain why certain people may have differences in gut barrier resilience, inflammatory signaling, and responses to dietary compounds—useful context for prevention and symptom-management strategies.
: SLC22A4 helps transport ergothioneine, a compound found in high amounts in mushrooms. Evidence suggests certain SLC22A4 variants can increase ergothioneine transport, which may exacerbate IBD symptoms in some genetically susceptible individuals—even though ergothioneine is generally considered an antioxidant. This report connects your SLC22A4 genetic variants to practical guidance, helping you understand whether mushroom intake could be a relevant dietary variable to monitor as part of a personalized gut health plan.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
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A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.88 out of 5 based on 8 customer ratings

4.9 (9 reviews)

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Terrence D.

Rated 4 out of 5
Clear SLC22A4 guidance, but I wish it included a simple food swap checklist for arachidonic acid sources.
Kendra M.

Rated 5 out of 5
My mom has always struggled with gut problems so I got this for her and ended up reading it myself too. It was surprisingly easy to understand and the recommendations made sense for our family history. Now we’re both adding more fiber and fermented foods daily.
Trent R.

Rated 5 out of 5
Arachidonic cut, calmer gut.
Laura C.

Rated 5 out of 5
I never realized how much gut inflammation was affecting me until I tried these changes. Really glad I gave it a shot.
River G.

Rated 5 out of 5
The SLC22A4 (Gut Inflammation) report connected a lot of dots for me. I have a family history of IBS, and I get flare ups after heavy restaurant meals. The section on arachidonic acid was the wake up call, I cut back on frequent fried foods and fatty processed meats, and swapped in more olive oil and fish. I also followed the fiber and fermented foods plan, starting slowly with oats, lentils, and kefir. Adding a butyrate supplement plus curcumin made my mornings noticeably calmer within a few weeks.

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SLC22A4 (Gut Inflammation)

Product features

Understanding Your SLC22A4 (Gut Inflammation) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the SLC22A4 (Gut Inflammation) gene do?

Why is the SLC22A4 (Gut Inflammation) gene important?

What can I do based on my SLC22A4 (Gut Inflammation) results?

Is SLC22A4 linked to Crohn’s disease and IBD risk?

What does SLC22A4 genetic testing tell me about mushroom intolerance or sensitivity?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers