What does the IBD5 (Gut Inflammation) gene do?

IBD5 isn’t a single gene—it’s a region on chromosome 5 that contains multiple genes linked to gut inflammation and immune signaling. This region includes genes involved in regulating immune messengers (like cytokines and interferon-related pathways) and transport proteins such as SLC22A4 and SLC22A5 (OCTN1/OCTN2), which help move carnitine into cells lining the gut. Carnitine transport matters because gut-lining cells rely on efficient nutrient handling and energy balance to maintain a healthy barrier and manage inflammatory stress.

Why is the IBD5 (Gut Inflammation) gene important?

Variants in the IBD5 region have been repeatedly associated with higher rates of inflammatory bowel disease (IBD), including Crohn’s disease and, for some variants, ulcerative colitis. Large analyses have reported increased odds of Crohn’s disease for certain IBD5 variants (for example, rs2188962 has been linked to higher Crohn’s risk in meta-analyses). Research also suggests that IBD5 risk variants can be associated with reduced expression of SLC22A5, which may impair carnitine transport in gut tissue—potentially making the intestinal lining more vulnerable to inflammation. Knowing your IBD5 genotype helps you understand whether you may have a genetically increased susceptibility in these pathways.

What can I do based on my IBD5 (Gut Inflammation) results?

Based on your IBD5 (Gut Inflammation) results, you’ll receive 4 personalized recommendations focused on dietary and supplement actions. These recommendations translate your genotype into practical next steps—such as targeted nutrition strategies that support a calmer inflammatory response and guidance on supplements that may help support gut-lining function and related nutrient transport pathways. Your report is designed to help you prioritize the interventions most relevant to your genetic profile, rather than relying on generic gut-health advice.

How is the IBD5 (Gut Inflammation) gene linked to Crohn’s disease risk?

The IBD5 region on chromosome 5 is one of the most consistently replicated genetic associations with IBD. Studies and meta-analyses have found that certain variants in this region are associated with higher odds of Crohn’s disease, including rs2188962 (reported as increased risk per “T” allele in large datasets). Additional IBD5 variants, including those near SLC22A4 and SLC22A5 (OCTN1/OCTN2), have been associated with increased IBD rates across multiple studies. Mechanistically, these variants may influence gene expression—particularly reduced SLC22A5 expression—which can affect carnitine transport in gut tissue and may contribute to a more inflammation-prone intestinal environment. This report helps you see whether you carry these higher-risk patterns and what to do next with diet and supplement strategies.

What SNPs are included in IBD5 (Gut Inflammation) genetic testing, and what do they mean?

This report analyzes 4 SNPs in the IBD5 region that have been studied in relation to IBD risk. Research highlights include rs2188962 (associated with higher Crohn’s disease risk in meta-analyses), rs1050152 (in SLC22A4/OCTN1), rs2631367 (in SLC22A5/OCTN2), and rs12521868 (reported as significantly associated with higher IBD rates in a meta-analysis). These variants are often inherited together as part of the IBD5 haplotype, which is why they can cluster in families. Your results explain what your specific genotype suggests about inflammatory susceptibility and gut-lining nutrient transport—then provide 4 personalized, evidence-based dietary and supplement recommendations tailored to your findings.

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IBD5 (Gut Inflammation)

Rated 4.71 out of 5 based on 14 customer ratings

4.7 (15 reviews)

IBD5 (Gut Inflammation)

Rated 4.71 out of 5 based on 14 customer ratings

4.7 (15 reviews)

The report provides up to 4 personalized recommendations based on 4 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes 4 Genetic Variants

Up to 4 DNA-Based, Science-Backed Recommendations

IBD5 (Gut Inflammation)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your IBD5 (Gut Inflammation) Variants: A DNA Gene Report

Do certain foods seem to “set off” your gut, even when you’re trying to eat well? Have you ever wondered why inflammation or digestive flare-ups can run in families? And what if your DNA could reveal whether your gut lining may be more sensitive to inflammatory triggers? Your IBD5 (Gut Inflammation) results help you understand genetic variants linked to inflammatory bowel disease (IBD) risk—so you can make more targeted choices to support gut resilience.

Key Report Highlights

This IBD5 (Gut Inflammation) Gene Report analyzes 4 research-backed genetic variants (SNPs) in the IBD5 region on chromosome 5 and delivers 4 personalized recommendations tailored to your genotype. The IBD5 region includes genes involved in immune signaling (e.g., interferon regulation and cytokines) and gut barrier support, as well as SLC22A4/SLC22A5 transporters that help move carnitine into gut-lining cells. A compelling finding from human and animal research: reduced activity of these transporters can contribute to carnitine deficiency in the gut lining—linked to inflammation and tissue damage in models lacking OCTN2.

Personalized, Actionable Recommendations

Your recommendations are personalized to how your specific IBD5 (Gut Inflammation) variants may influence immune activity and nutrient transport in the gut. You’ll receive a focused set of dietary and supplement recommendations (4 total) designed to be practical and actionable. For example, your plan may include food strategies that emphasize anti-inflammatory, gut-supportive patterns (such as optimizing fiber type/tolerance or reducing common dietary triggers) and supplement guidance aimed at supporting gut-lining nutrition and inflammatory balance (such as carnitine-related support or targeted nutrients commonly used for mucosal and immune support), aligned to your genotype and the evidence behind each recommendation.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: IBD5 isn’t a single gene—it’s a region on chromosome 5 that contains multiple genes linked to gut inflammation and immune signaling. This region includes genes involved in regulating immune messengers (like cytokines and interferon-related pathways) and transport proteins such as SLC22A4 and SLC22A5 (OCTN1/OCTN2), which help move carnitine into cells lining the gut. Carnitine transport matters because gut-lining cells rely on efficient nutrient handling and energy balance to maintain a healthy barrier and manage inflammatory stress.
: Variants in the IBD5 region have been repeatedly associated with higher rates of inflammatory bowel disease (IBD), including Crohn’s disease and, for some variants, ulcerative colitis. Large analyses have reported increased odds of Crohn’s disease for certain IBD5 variants (for example, rs2188962 has been linked to higher Crohn’s risk in meta-analyses). Research also suggests that IBD5 risk variants can be associated with reduced expression of SLC22A5, which may impair carnitine transport in gut tissue—potentially making the intestinal lining more vulnerable to inflammation. Knowing your IBD5 genotype helps you understand whether you may have a genetically increased susceptibility in these pathways.
: Based on your IBD5 (Gut Inflammation) results, you’ll receive 4 personalized recommendations focused on dietary and supplement actions. These recommendations translate your genotype into practical next steps—such as targeted nutrition strategies that support a calmer inflammatory response and guidance on supplements that may help support gut-lining function and related nutrient transport pathways. Your report is designed to help you prioritize the interventions most relevant to your genetic profile, rather than relying on generic gut-health advice.
: The IBD5 region on chromosome 5 is one of the most consistently replicated genetic associations with IBD. Studies and meta-analyses have found that certain variants in this region are associated with higher odds of Crohn’s disease, including rs2188962 (reported as increased risk per “T” allele in large datasets). Additional IBD5 variants, including those near SLC22A4 and SLC22A5 (OCTN1/OCTN2), have been associated with increased IBD rates across multiple studies. Mechanistically, these variants may influence gene expression—particularly reduced SLC22A5 expression—which can affect carnitine transport in gut tissue and may contribute to a more inflammation-prone intestinal environment. This report helps you see whether you carry these higher-risk patterns and what to do next with diet and supplement strategies.
: This report analyzes 4 SNPs in the IBD5 region that have been studied in relation to IBD risk. Research highlights include rs2188962 (associated with higher Crohn’s disease risk in meta-analyses), rs1050152 (in SLC22A4/OCTN1), rs2631367 (in SLC22A5/OCTN2), and rs12521868 (reported as significantly associated with higher IBD rates in a meta-analysis). These variants are often inherited together as part of the IBD5 haplotype, which is why they can cluster in families. Your results explain what your specific genotype suggests about inflammatory susceptibility and gut-lining nutrient transport—then provide 4 personalized, evidence-based dietary and supplement recommendations tailored to your findings.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.71 out of 5 based on 14 customer ratings

4.7 (15 reviews)

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Marshall E.

Rated 5 out of 5
The IBD5 report gave me a realistic, stepwise gut plan instead of vague “reduce inflammation” slogans. It explained how my genetics may tilt me toward stronger gut immune responses, which fits my family history of colitis. I used the fiber guidance to hit a daily target, added kefir and sauerkraut, and introduced prebiotics slowly to avoid gas. The butyrate section helped me pick a form that didn’t upset my stomach, and curcumin with meals reduced that burning feeling after spicy food. Two months later, fewer flare days and better confidence about what to try next.
Destiny M.

Rated 5 out of 5
I’ve had on and off abdominal pain since college and always chalked it up to stress. The IBD5 (Gut Inflammation) report made me look at patterns I was ignoring, especially how low fiber weeks lined up with symptoms. I followed the “eat more fiber and fermented foods” suggestions, starting with chia, oats, and a small daily serving of kimchi. I also added curcumin and a butyrate supplement, and used prebiotics only every other day at first. After about a month, my stools were more consistent and the random urgency eased. I like that it gave a clear ramp up schedule.
Keisha R.

Rated 5 out of 5
Fermented foods, fewer flares.
David L.

Rated 3 out of 5
Helpful plan, but I worried it oversold supplements, I wanted stronger cautions about interactions and when to ask a clinician.
Wayne V.

Rated 4 out of 5
Useful, but the gene explanations could be a touch simpler for non-science folks. Still, the fiber and butyrate tips were great.

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IBD5 (Gut Inflammation)

Product features

Understanding Your IBD5 (Gut Inflammation) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the IBD5 (Gut Inflammation) gene do?

Why is the IBD5 (Gut Inflammation) gene important?

What can I do based on my IBD5 (Gut Inflammation) results?

How is the IBD5 (Gut Inflammation) gene linked to Crohn’s disease risk?

What SNPs are included in IBD5 (Gut Inflammation) genetic testing, and what do they mean?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers