What does the ALAD (Lead) gene do?

The ALAD (Lead) gene provides instructions for making an enzyme called delta-aminolevulinate dehydratase. This enzyme helps your body produce heme, a vital molecule used to build hemoglobin (which carries oxygen in red blood cells) and other heme-containing proteins. ALAD performs an early step in the heme pathway by combining two molecules of delta-aminolevulinic acid into a compound called porphobilinogen, and it relies on zinc to function properly.

Why is the ALAD (Lead) gene important?

ALAD matters because changes (variants) in this gene can influence ALAD enzyme activity and how the enzyme interacts with heavy metals—especially lead. Some common ALAD variants have been associated in research with differences in blood lead levels (and, in certain contexts, stronger effects of lead on cognitive performance), particularly among people with meaningful exposure. While study results can be mixed, understanding your ALAD variants can add a personalized layer to how you think about detox-related risk, exposure awareness, and prevention strategies.

What can I do based on my ALAD (Lead) results?

Based on your ALAD (Lead) results, you’ll receive 1 personalized recommendation focused on lifestyle actions you can take. This guidance is designed to be practical and genotype-informed—for example, it may emphasize reducing common sources of lead exposure (water, older paint/dust, certain hobbies or occupations) and supporting ALAD-related biology through healthy routines such as nutrition patterns that help maintain essential cofactors (like zinc) and overall metabolic resilience.

Can ALAD gene variants increase the risk of high blood lead levels?

They may contribute, especially when exposure is present. Research on several ALAD variants suggests certain alleles can be associated with higher lead levels in blood (and sometimes urine or placental tissue) in exposed individuals, potentially because the altered ALAD protein can bind lead more strongly. However, findings are not consistent across all studies, and genetics is only one part of the picture—environmental exposure level, occupation, home conditions (older paint/dust), water sources, nutrition, and overall health also strongly influence lead burden. This report helps you understand whether your genotype is among those that have been linked to differences in lead handling, so you can prioritize prevention and exposure reduction appropriately.

What is included in ALAD (Lead) genetic testing in this DNA report?

This ALAD (Lead) DNA report analyzes 3 specific ALAD SNPs that have been studied in relation to ALAD enzyme function and lead-associated outcomes. Your results are then translated into 1 personalized, lifestyle-based recommendation that focuses on actionable steps you can take based on your genotype. The goal is to turn complex genetics into clear, practical guidance—helping you understand how your ALAD variants may relate to lead binding, potential differences in lead levels under exposure, and personalized detox-focused prevention strategies.

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ALAD (Lead)

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

ALAD (Lead)

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

The report provides up to 1 personalized recommendations based on 3 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes 3 Genetic Variants

Up to 1 DNA-Based, Science-Backed Recommendations

ALAD (Lead)

$59 $29

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Product features

Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your ALAD (Lead) Variants: A DNA Gene Report

Do you ever wonder why two people can have the same environmental exposure but very different outcomes? Have you been curious about how your body handles heavy metals like lead—and whether your genetics might make you more sensitive? The ALAD (Lead) gene report helps you understand how your unique ALAD variants may influence a key enzyme involved in heme production, which can relate to differences in lead binding and lead levels in the body.

Key Report Highlights

This DNA report analyzes 3 well-studied genetic variants (SNPs) in the ALAD (Lead) gene and delivers 1 personalized recommendation tailored to your results. ALAD encodes delta-aminolevulinate dehydratase, a zinc-dependent enzyme that performs an early step in heme production—an essential component of hemoglobin, the protein that carries oxygen in your blood. Compellingly, certain ALAD variants may change how strongly the enzyme binds lead, which has been linked in some studies to higher lead levels in blood and other tissues, especially in people with exposure.

Personalized, Actionable Recommendations

Your recommendations are personalized to your ALAD (Lead) genotype—so the guidance is based on how your specific variants may influence lead handling and detox-related risk. This report includes lifestyle-focused recommendations that translate your genetics into practical next steps. Examples of the type of advice you may see include strategies to reduce lead exposure in daily life (e.g., home, water, hobbies, workplace) and nutrition-oriented lifestyle habits that support healthy heme-related pathways and mineral balance (such as ensuring adequate zinc intake through diet, as zinc is a key cofactor for the ALAD enzyme).

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: The ALAD (Lead) gene provides instructions for making an enzyme called delta-aminolevulinate dehydratase. This enzyme helps your body produce heme, a vital molecule used to build hemoglobin (which carries oxygen in red blood cells) and other heme-containing proteins. ALAD performs an early step in the heme pathway by combining two molecules of delta-aminolevulinic acid into a compound called porphobilinogen, and it relies on zinc to function properly.
: ALAD matters because changes (variants) in this gene can influence ALAD enzyme activity and how the enzyme interacts with heavy metals—especially lead. Some common ALAD variants have been associated in research with differences in blood lead levels (and, in certain contexts, stronger effects of lead on cognitive performance), particularly among people with meaningful exposure. While study results can be mixed, understanding your ALAD variants can add a personalized layer to how you think about detox-related risk, exposure awareness, and prevention strategies.
: Based on your ALAD (Lead) results, you’ll receive 1 personalized recommendation focused on lifestyle actions you can take. This guidance is designed to be practical and genotype-informed—for example, it may emphasize reducing common sources of lead exposure (water, older paint/dust, certain hobbies or occupations) and supporting ALAD-related biology through healthy routines such as nutrition patterns that help maintain essential cofactors (like zinc) and overall metabolic resilience.
: They may contribute, especially when exposure is present. Research on several ALAD variants suggests certain alleles can be associated with higher lead levels in blood (and sometimes urine or placental tissue) in exposed individuals, potentially because the altered ALAD protein can bind lead more strongly. However, findings are not consistent across all studies, and genetics is only one part of the picture—environmental exposure level, occupation, home conditions (older paint/dust), water sources, nutrition, and overall health also strongly influence lead burden. This report helps you understand whether your genotype is among those that have been linked to differences in lead handling, so you can prioritize prevention and exposure reduction appropriately.
: This ALAD (Lead) DNA report analyzes 3 specific ALAD SNPs that have been studied in relation to ALAD enzyme function and lead-associated outcomes. Your results are then translated into 1 personalized, lifestyle-based recommendation that focuses on actionable steps you can take based on your genotype. The goal is to turn complex genetics into clear, practical guidance—helping you understand how your ALAD variants may relate to lead binding, potential differences in lead levels under exposure, and personalized detox-focused prevention strategies.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.86 out of 5 based on 7 customer ratings

4.9 (8 reviews)

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Shane T.

Rated 5 out of 5
Honestly found it super interesting and made me rethink a few habits!
Hailey W.

Rated 5 out of 5
I was surprised by how much I learned about my own risk for lead exposure. Gave me a couple of things to change at home right away.
Lance D.

Rated 5 out of 5
Shared my results with my naturopath and she immediately said this is exactly the kind of info she wishes all her patients had. Super actionable and gave us a clear direction to help minimize lead exposure. Useful reference to have in my medical file too.
Mason C.

Rated 5 out of 5
I work in renovation, so lead is not an abstract risk for me. The ALAD (Lead) report helped me understand why I should take exposure seriously and what to do about it without panic. I followed the lifestyle guidance to avoid lead exposure, swapped out a few old tools, upgraded my mask, and got more strict about wet cleanup instead of dry sweeping. I also checked our tap setup and stopped using chipped vintage mugs. It gave me a clear plan I could actually follow.
Nia D.

Rated 4 out of 5
Lead-proofing, almost perfectly mapped.

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ALAD (Lead)

Product features

Understanding Your ALAD (Lead) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the ALAD (Lead) gene do?

Why is the ALAD (Lead) gene important?

What can I do based on my ALAD (Lead) results?

Can ALAD gene variants increase the risk of high blood lead levels?

What is included in ALAD (Lead) genetic testing in this DNA report?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers