What does the HMGCR (Cholesterol) gene do?

HMGCR is the gene that provides instructions for making HMG‑CoA reductase, an enzyme your body uses to produce cholesterol. It’s considered the “rate-limiting” step in cholesterol synthesis—meaning it helps control how fast the overall cholesterol-production pathway runs. When HMGCR activity is higher, the body may produce more cholesterol; when it slows down, cholesterol production can decrease. HMGCR also plays a role in immune function through involvement in T cell activation.

Why is the HMGCR (Cholesterol) gene important?

HMGCR is important because genetic variants can influence how much HMG‑CoA reductase your body produces or how it functions—potentially shifting cholesterol-related markers like LDL, total cholesterol, apoB, and HDL. Research has linked specific HMGCR variants to higher cholesterol levels and broader health associations, including cardiovascular outcomes (such as myocardial infarction risk signals), cognition-related outcomes (including Alzheimer’s disease and mild cognitive impairment associations), and certain cancer-related findings (including ovarian cancer associations). Some variants are also associated with differences in statin response, which can be clinically meaningful for people managing elevated LDL cholesterol.

What can I do based on my HMGCR (Cholesterol) results?

Based on your HMGCR results, you’ll receive 4 personalized recommendations designed to be actionable and relevant to your genotype. These include drug-focused guidance (such as insights related to statin responsiveness) and supplement-focused guidance (options that may support healthy lipid metabolism in a personalized plan). The goal is to help you prioritize next steps—what to discuss with your healthcare provider, what to monitor (like LDL/apoB), and which strategies may be more or less likely to fit your genetic profile.

Which HMGCR variants are linked to high cholesterol and statin response?

Studies have highlighted several HMGCR polymorphisms in relation to cholesterol markers and statin response. For example, rs3846662 has been widely studied; the G allele has been associated with higher LDL, apoB, and total cholesterol (and lower HDL in some findings), and it has also been linked to greater LDL lowering in response to statins in multiple studies. Another well-researched variant, rs12916, has been associated with higher total and LDL cholesterol and has also been linked to increased statin effectiveness in research. In contrast, rs17244841 (T allele) and rs17238540 (G allele) have been associated with reduced statin effectiveness at lowering LDL cholesterol in some studies. This report analyzes 4 SNPs in HMGCR and explains what your specific combination may suggest—so you can bring more personalized context to cholesterol management decisions with your clinician.

What is an HMGCR genetic test report and what will I learn from it?

An HMGCR genetic test report is a DNA-based analysis focused on variants in the HMGCR gene, which helps regulate the body’s cholesterol production. In this report, 4 HMGCR SNPs are analyzed to identify genetic patterns associated in research with cholesterol levels, statin responsiveness, and broader health signals related to cognition, heart & blood vessels, and certain cancers. You’ll learn how your genotype may influence cholesterol biology (such as tendencies toward higher LDL-related markers) and you’ll receive 4 personalized recommendations—covering drug-related considerations and supplement guidance—designed to help you take clearer, more individualized next steps.

Save $30

HMGCR (Cholesterol)

Rated 4.83 out of 5 based on 6 customer ratings

4.8 (7 reviews)

HMGCR (Cholesterol)

Rated 4.83 out of 5 based on 6 customer ratings

4.8 (7 reviews)

The report provides up to 4 personalized recommendations based on 4 genetic variants analyzed. Purchase a DNA kit to generate your genetic results. If you've already got one, you're all set to continue. View sample report.

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Analyzes 4 Genetic Variants

Up to 4 DNA-Based, Science-Backed Recommendations

HMGCR (Cholesterol)

$59 $29

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Note: To generate your personalized report, purchase a SelfDecode DNA kit. If you already have one, you’re ready to proceed.

Understanding Your HMGCR (Cholesterol) Variants: A DNA Gene Report

Have you ever wondered why your cholesterol numbers don’t always match your diet—or why heart and brain health risks can run in families? Are you curious whether your body may naturally “turn up” cholesterol production, even when you’re doing many things right? The HMGCR (Cholesterol) Gene Report helps you understand how your HMGCR variants may influence cholesterol production and what that could mean for cognition, heart & blood vessels, and even certain cancer-related risks—so you can make more personalized, informed choices.

Key Report Highlights

This report analyzes 4 genetic variants (SNPs) in the HMGCR (Cholesterol) gene and delivers 4 personalized recommendations tailored to your genotype. HMGCR encodes HMG‑CoA reductase—the rate-limiting enzyme in the body’s cholesterol-making pathway—meaning it helps set the pace for how much cholesterol your body produces. Compellingly, certain HMGCR variants have been associated not only with higher LDL cholesterol, but also with outcomes that extend beyond the heart, including Alzheimer’s disease risk signals and ovarian cancer associations in research.

Personalized, Actionable Recommendations

Your results translate into genotype-based, personalized guidance—so you’re not left guessing what matters for you. You’ll receive 4 targeted recommendations that can include drug-related insights (for example, how your variants may relate to statin responsiveness) and supplement considerations aligned with your genetic profile. Depending on your SNP pattern, the report may highlight that some variants are linked to greater LDL reduction with statin therapy, while others have been associated with reduced statin effectiveness—helping you have a more informed conversation with your clinician about medication strategy and supportive options.

User-Friendly Format and Trust

With actionable and easy-to-understand recommendations, the report is designed for seamless integration into your daily life. Its user-friendly format ensures accessibility, making complex genetic data understandable and practical for users at all levels of familiarity with genetic information.

The report is rooted in accuracy and reliability, backed by comprehensive scientific research from reputable sources. It has garnered the trust of over 150,000 users and 1,000+ healthcare professionals. Furthermore, the report complies with HIPAA and GDPR, ensuring your privacy and security are prioritized.

Getting Started

To embark on this journey, simply purchase a DNA kit for an easy at-home sample collection, guaranteeing a hassle-free process. Delve into a personalized approach to wellness and equip yourself with actionable insights to enrich your life and health.

Product FAQs

: HMGCR is the gene that provides instructions for making HMG‑CoA reductase, an enzyme your body uses to produce cholesterol. It’s considered the “rate-limiting” step in cholesterol synthesis—meaning it helps control how fast the overall cholesterol-production pathway runs. When HMGCR activity is higher, the body may produce more cholesterol; when it slows down, cholesterol production can decrease. HMGCR also plays a role in immune function through involvement in T cell activation.
: HMGCR is important because genetic variants can influence how much HMG‑CoA reductase your body produces or how it functions—potentially shifting cholesterol-related markers like LDL, total cholesterol, apoB, and HDL. Research has linked specific HMGCR variants to higher cholesterol levels and broader health associations, including cardiovascular outcomes (such as myocardial infarction risk signals), cognition-related outcomes (including Alzheimer’s disease and mild cognitive impairment associations), and certain cancer-related findings (including ovarian cancer associations). Some variants are also associated with differences in statin response, which can be clinically meaningful for people managing elevated LDL cholesterol.
: Based on your HMGCR results, you’ll receive 4 personalized recommendations designed to be actionable and relevant to your genotype. These include drug-focused guidance (such as insights related to statin responsiveness) and supplement-focused guidance (options that may support healthy lipid metabolism in a personalized plan). The goal is to help you prioritize next steps—what to discuss with your healthcare provider, what to monitor (like LDL/apoB), and which strategies may be more or less likely to fit your genetic profile.
: Studies have highlighted several HMGCR polymorphisms in relation to cholesterol markers and statin response. For example, rs3846662 has been widely studied; the G allele has been associated with higher LDL, apoB, and total cholesterol (and lower HDL in some findings), and it has also been linked to greater LDL lowering in response to statins in multiple studies. Another well-researched variant, rs12916, has been associated with higher total and LDL cholesterol and has also been linked to increased statin effectiveness in research. In contrast, rs17244841 (T allele) and rs17238540 (G allele) have been associated with reduced statin effectiveness at lowering LDL cholesterol in some studies. This report analyzes 4 SNPs in HMGCR and explains what your specific combination may suggest—so you can bring more personalized context to cholesterol management decisions with your clinician.
: An HMGCR genetic test report is a DNA-based analysis focused on variants in the HMGCR gene, which helps regulate the body’s cholesterol production. In this report, 4 HMGCR SNPs are analyzed to identify genetic patterns associated in research with cholesterol levels, statin responsiveness, and broader health signals related to cognition, heart & blood vessels, and certain cancers. You’ll learn how your genotype may influence cholesterol biology (such as tendencies toward higher LDL-related markers) and you’ll receive 4 personalized recommendations—covering drug-related considerations and supplement guidance—designed to help you take clearer, more individualized next steps.

WHY SELFDECODE?

Empowering Your Well-being Journey

This personalized health report is powered by SelfDecode's cutting-edge AI technology, designed to unlock a deeper understanding of your health potential. We're committed to providing you with the most accurate and actionable insights to guide your well-being journey.

Most Accurate
Polygenic Risk Scoring

We leverage cutting-edge algorithms and analyze a massive dataset of 2 million people to deliver the most precise assessment of your genetic health predispositions. Our advanced approach takes into account your ancestry - which is often overlooked by other methods - to provide you with the most accurate risk assessment. This ensures that the risk scores you receive are based on the latest scientific evidence and are truly personalized to your genetic makeup.

Cutting-Edge AI &
Machine Learning

We have invested 20 million dollars developing our AI and machine learning models. Our patent-pending technology provides you with the most personalized health insights and recommendations by taking into account your unique DNA, lifestyle, labs, symptoms, conditions and health goals. This empowers you to make informed decisions tailored to your specific needs.

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

We go beyond the basics by analyzing a staggering 200 million genetic variants to provide the most comprehensive picture of your health potential. Our sophisticated recommendation engine leverages this deep analysis to provide personalized and actionable insights to optimize your well-being journey.

Built by Leading
Scientists & Engineers

A dedicated team of over 60 scientists and engineers is continuously innovating and developing our technology, ensuring it remains at the forefront of personalized health.

Reviews

Rated 4.83 out of 5 based on 6 customer ratings

4.8 (7 reviews)

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Yara A.

Rated 5 out of 5
I never write reviews, but I actually learned a ton from this! Surprised at how specific the recommendations were. Wish I’d known about supplements like geranylgeraniol before.
Fatima A.

Rated 5 out of 5
Great insights on how my genetics affect cholesterol and mental focus. I did find a couple spots too full of science words though, and had to Google some terminology. Overall, it helped me pick supplements confidently, so I’d still recommend it just maybe needs a plain English version.
Tariq E.

Rated 4 out of 5
I got the HMGCR (Cholesterol) report mainly because high LDL runs in my family, but I liked that it framed cholesterol management through cognition, not just heart risk. The section on CoQ10 and ubiquinol was practical, and it explained why some people feel mentally flat when cholesterol pathways are pushed too hard. It also mentioned ezetimibe as a discussion point with a clinician, which I appreciated. Four stars because I wanted a clearer “when to consider what” flowchart, and a short note on interactions would help. Still, it made my next lab review more focused.
Xiao M.

Rated 5 out of 5
我一直以为胆固醇只是心血管问题，没想到这个 HMGCR（Cholesterol）报告把它和认知健康讲得很清楚。报告提示我可能更容易在用降脂策略时出现 CoQ10 相关的能量下降风险，于是我改用 ubiquinol，并在医生同意下了解了依折麦布（Ezetimibe）的思路。还提到 geranylgeraniol 对某些人可能有帮助。我照着做了四周，下午脑雾少了，专注时间更稳定，读论文不再频繁走神。
Emi G.

Rated 5 out of 5
Really informative, and I appreciated the science behind the recommendations like CoQ10 and ubiquinol. My only issue is the layout. Some sections felt a bit jammed together and hard to scan quickly. Would’ve liked a clear summary at the top. Still, so helpful for understanding my results.

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HMGCR (Cholesterol)

Product features

Understanding Your HMGCR (Cholesterol) Variants: A DNA Gene Report

Key Report Highlights

Personalized, Actionable Recommendations

User-Friendly Format and Trust

Getting Started

Product FAQs

What does the HMGCR (Cholesterol) gene do?

Why is the HMGCR (Cholesterol) gene important?

What can I do based on my HMGCR (Cholesterol) results?

Which HMGCR variants are linked to high cholesterol and statin response?

What is an HMGCR genetic test report and what will I learn from it?

WHY SELFDECODE?

Empowering Your Well-being Journey

Most AccuratePolygenic Risk Scoring

Cutting-Edge AI &Machine Learning

Analyzes 200 Million Variants & Sophisticated Recommendation Engine

Built by Leading Scientists & Engineers

Reviews

Related Products

Most Accurate
Polygenic Risk Scoring

Cutting-Edge AI &
Machine Learning

Built by Leading
Scientists & Engineers