Mechanism:

The VKORC1 gene has been linked to warfarin sensitivity. The vitamin K epoxide reductase enzyme complex (VKOR) is involved in the synthesis of vitamin K-dependent coagulation factors, which is the target enzyme for warfarin.

The T (minor) allele is associated with:

  • In venous thromboembolism (from hypercoagulability), people with the T allele require significantly reduced doses of warfarin and are (otherwise) at a higher risk of serious bleeding (R).
  • This suggests that people with the T allele have less vitamin K coagulation.

rs9923231

Parent Gene: BCKDK, VKORC1

Importance: 3
Less common allele: T = 36%
More common allele: C = 64%
My Genotype: Log In
Risk Allele: T, A
Significance: drug response

Disease/Trait: Response To Anticoagulant

rs9923231 is associated with Response To Anticoagulant (R) . It is reported to association with Warfarin maintenance dose. No specific risk allele was identified in the study.