The VKORC1 gene has been linked to warfarin sensitivity. The vitamin K epoxide reductase enzyme complex (VKOR) is involved in the synthesis of vitamin K-dependent coagulation factors, which is the target enzyme for warfarin.
The T (minor) allele is associated with:
- In venous thromboembolism (from hypercoagulability), people with the T allele require significantly reduced doses of warfarin and are (otherwise) at a higher risk of serious bleeding (R).
- This suggests that people with the T allele have less vitamin K coagulation.