Mechanism:

  • Studies show higher levels of the protein CHRNA3 in cancerous tissue compared to normal tissue [R].

The G (major) allele is associated with:

  • Decreased susceptibility to lung cancer (12-28% decreased risk) [R][R]. (in white smokers [R])
  • Protective effects for those who smoke [R] (especially in Asian men) [R].

The A (minor) allele is associated with:

  • Increased risk of lung cancer [R].

This SNP is associated with (unknown which alleles):

  • increased risk of smoking initiation and susceptibility to lung cancer [R].
  • Chronic lung disease, like bronchitis or emphysema caused by conjunction with other SNPs [R].

rs938682

Parent Gene: CHRNA3

Importance: 3
Less common allele: G = 40%
More common allele: A = 60%
My Genotype: Log In
Risk Allele: A, A

Disease/Trait: Forced Expiratory Volume

The A allele of rs938682 is reported to be associated with Forced Expiratory Volume (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Response To Bronchodilator

The A allele of rs938682 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1.

Disease/Trait: Fev/Fec Ratio

The A allele of rs938682 is reported to be associated with Fev/fec Ratio (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.

Disease/Trait: Response To Bronchodilator

The A allele of rs938682 is reported to be associated with Response To Bronchodilator (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Post bronchodilator FEV1/FVC ratio.