- Studies show higher levels of the protein CHRNA3 in cancerous tissue compared to normal tissue [R].
The G (major) allele is associated with:
- Decreased susceptibility to lung cancer (12-28% decreased risk) [R][R]. (in white smokers [R])
- Protective effects for those who smoke [R] (especially in Asian men) [R].
The A (minor) allele is associated with:
- Increased risk of lung cancer [R].
This SNP is associated with (unknown which alleles):