rs891512 (also known as G24943A, IVS25+15 [G→A]) is an intronic variant in the NOS3 gene significantly associated with blood pressure.

[PMID 18246059] The intronic variant, IVS25+15 [G-->A], was significantly associated with blood pressure; GG homozygotes had significantly lower levels of diastolic blood pressure (DBP) (-2.8 mm Hg; P = 0.016) and systolic blood pressure (SBP) (-1.9 mm Hg; P = 0.018) than A-allele carriers.

[PMID 22425436] eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p<0.05).

[PMID 17367796] Two specific SNPs in significant LD with each other (rs891512 and rs1808593) were significantly associated with ABI (ankle-brachial index) in both subsets.

[PMID 17579350] protective haplotype C-T-A (rs2070744-rs1799983-rs891512) was observed (P = 0.01) with a pronounced effect against suicide completion (P = 0.005).

[PMID 17605790] Lack of association between endothelial nitric oxide synthase (NOS3) gene polymorphisms and suicide attempts.

[PMID 18482449] Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites.

[PMID 19493349] 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.

[PMID 21577011] NCAM1, TACR1 and NOS genes and temperament: a study on suicide attempters and controls.

[PMID 26505452] Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population


Parent Gene: NOS3

Importance: 1
Less common allele: A = 11%
More common allele: G = 89%
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