rs887829 is a SNP in the UGT1A1 gene. The minor allele of this SNP has been reported to be associated with higher levels of serum bilirubin, which has an inverse correlation with coronary artery disease.

[PMID 19238116] Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population. This study of 2,000+ patients reports a recessive protective effect against coronary artery disease for the minor allele, with an age-adjusted odds ratio of 0.24 (CI: 0.10-0.60, p=0.0014).



[PMID 21309756] Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations


[PMID 22085899] UGT1A1 is a major locus influencing bilirubin levels in African Americans


[PMID 17424838] [Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].


[PMID 18349273] UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk.


[PMID 19267064] [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].


[PMID 19414484] Genome-wide association meta-analysis for total serum bilirubin levels.


[PMID 19482841] Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.





[PMID 23642732] Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study


[PMID 23092954] SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.


[PMID 26413716] A GWAS Study on Liver Function Test Using eMERGE Network Participants

rs887829


Importance: 5
Less common allele: T = 35%
More common allele: C = 65%
My Genotype: Log In
Risk Allele: T, T, T, T, A, T, T, T, T, T, T, T, T, T, T, T

Disease/Trait: Metabolite Measurement

The T allele of rs887829 is reported to be associated with Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolite levels (Bilirubin).

Disease/Trait: Bilirubin Measurement

The T allele of rs887829 is reported to be associated with Bilirubin Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Bilirubin levels.

Disease/Trait: Bilirubin Measurement

The T allele of rs887829 is reported to be associated with Bilirubin Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Bilirubin levels.

Disease/Trait: Metabolite Measurement

The T allele of rs887829 is reported to be associated with Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolic traits (SM-4 + 74 other traits).

Disease/Trait: Bilirubin Measurement

The A allele of rs887829 is reported to be associated with Bilirubin Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cholelithiasis-related traits in sickle cell anemia.

Disease/Trait: Sickle Cell Anemia

The A allele of rs887829 is reported to be associated with Sickle Cell Anemia (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cholelithiasis-related traits in sickle cell anemia.

Disease/Trait: Cholelithiasis

The A allele of rs887829 is reported to be associated with Cholelithiasis (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Cholelithiasis-related traits in sickle cell anemia.

Disease/Trait: Serum Metabolite Measurement

The T allele of rs887829 is reported to be associated with Serum Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Serum metabolite levels (Bilirubin (E,E)).

Disease/Trait: Serum Metabolite Measurement

The T allele of rs887829 is reported to be associated with Serum Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Serum metabolite levels (Bilirubin (Z,Z)).

Disease/Trait: Serum Metabolite Measurement

The T allele of rs887829 is reported to be associated with Serum Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Serum metabolite levels (Biliverdin).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs887829 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Blood metabolite levels (bilirubin (E,E)).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs887829 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Blood metabolite levels (bilirubin (E,Z or Z,E)).

Disease/Trait: Bilirubin Measurement

The T allele of rs887829 is reported to be associated with Bilirubin Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Bilirubin levels.

Disease/Trait: Bilirubin Measurement

The T allele of rs887829 is reported to be associated with Bilirubin Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Total bilirubin levels in HIV-1 infection.

Disease/Trait: Hiv-1 Infection

The T allele of rs887829 is reported to be associated with Hiv-1 Infection (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Total bilirubin levels in HIV-1 infection.