rs868 is a SNP in the transforming growth factor, beta receptor I TGFBR1 gene.

A total of 1,157 Spanish cases with urothelial cell carcinoma of the bladder and 1,157 matched controls were analyzed for TGFBR1 SNP associations, and among patients with muscle-invasive bladder cancer tumors, a significant association between rs868 and disease-specific mortality was found, with an allele dosage effect (p-trend = 0.003). [PMID 19004027]

[PMID 19299629] Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm.

[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19509225] Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients.


Parent Gene: TGFBR1

Importance: 1
Less common allele: G = 12%
More common allele: A = 88%
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