Mechanism:

  • G= associated with an increase in production of Vascular Endothelial Growth Factor (VEGF).[R], [R].

The "A" (minor) allele is associated with:

  • AA= Increased risk for vaso-occlusive crisis in individuals with Sickle Cell Disease [R].

  • Increased risk for cervical cancer [R], as part of the CTGCCAG haplotype regarding SNP’s rs699947/ rs833061/ rs1570360/  rs2010963/ rs25648/ rs833068/ rs833070, based on a study of Tunisian women.

  • AA with Ovarian cancer showed significantly lower survival, in one study of an Australian sample [R].

  • Higher risk for nasopharyngeal (Nose and throat) cancer  in individuals with the G/A genotype [R].

  • Increased risk for the condition preeclampsia in black women [R].  

  • Stronger recovery response to anti-VEGF treatment  for AMD (Age-related macular degeneration), or age-related blind spots [R].

The "G" allele is associated with:

  • GG= Higher risk for blinding Diabetic Retinopathy in individuals with Type 1 Diabetes [R].

  • Poor response to treatment with the drug Sunitinib, in patients with Biliary or Gastric Cancer. Homozygous dominant (G/G) individuals had quicker treatment failure than those with genotypes  (G/A) or (A/A). [R]

This SNP is associated with (unknown  which alleles):

  • Susceptibility to acute course sarcoidosis (only a few episodes, or lasting less than two years) [R], in association with SNPs Rs833060, and Rs3025000 as part of a gene block. 

rs833068

Parent Gene: VEGFA

Importance: 3
Less common allele: A = 38%
More common allele: G = 62%
My Genotype: Log In