Women with two rs821616(T) SNPs seem to experience more rapid cognitive decline as they age compared to men. [PMID 16054297]

[PMID 17673452] 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish Bipolar disorder families.

  • rs821616 verbal fluency

[PMID 19805229] DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

[PMID 21878470] Effect of DISC1 on the P300 Waveform in Psychosis

[PMID 22673686] Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population

[PMID 15386212] Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.

[PMID 15939883] Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.

[PMID 17286247] Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population.

[PMID 17997036] Association study of polymorphisms between DISC1 and schizophrenia in a Korean population.

[PMID 18072279] Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.

[PMID 19188535] Association of variants in DISC1 with psychosis-related traits in a large population cohort.

[PMID 19300510] The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.

[PMID 19414483] The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.

[PMID 20403199] High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.

[PMID 20531374] Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.

[PMID 23140672] DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study

[PMID 23602339] Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.

[PMID 25670952] Disrupted-in-Schizophrenia-1 SNPs and Susceptibility to Schizophrenia: Evidence from Malaysia


Parent Gene: DISC1

Importance: 1
Less common allele: T = 25%
More common allele: A = 75%
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