- T is the less common allele. This variant causes a lower level of PGC-1a protein including in muscles [R, R, R].
- The T allele results in a less efficient coactivator of transcription factors, including those that regulate the PPARGC1A gene itself [R].
The T (minor) allele is associated with:
- Increased blood pressure (for those under 50).
- Earlier onset of Huntington's [R, R].
- Increased levels of fatty acids (may be more difficult to clear fatty acids after consuming glucose) [R].
- Increased LDL cholesterol [R].
- Greater weight gain in men being treated for type 1 diabetes (given insulin) [R].
- Reduced inclination toward aerobic exercise [R].
- Increased muscular strength/power [R, R].
- Increased insulin resistance [R, R, R].
- Increased risk of developing type 2 diabetes [R, R, R].
- Increased risk of fatty liver disease and increased liver ALT enzymes [R].
- Signs of metabolic syndrome [R].
- Sarcoidosis [R].
- Hypertrophic cardiomyopathy [R].
The C (major) allele is associated with: